The differential impact of acute microglia activation on the excitability of cholinergic neurons in the mouse medial septum
Sign Up to like & getrecommendations! Published in 2019 at "Brain Structure and Function"
DOI: 10.1007/s00429-019-01905-w
Abstract: The medial septal nucleus is one of the basal forebrain nuclei that projects cholinergic input to the hippocampus and cortex. Two of the hallmarks of Alzheimer’s disease (AD) are a significant loss of cholinergic transmission… read more here.
Keywords: differential impact; cholinergic neurons; excitability; activation ... See more keywords
Neuroscience: Glutamate neurons in the medial septum control wakefulness
Sign Up to like & getrecommendations! Published in 2021 at "Current Biology"
DOI: 10.1016/j.cub.2021.03.006
Abstract: Despite intensive research efforts, biologists still do not have a clear picture of the brain circuitry that controls behavioural arousal. However, new research has identified a novel septo-hypothalamic circuit that functions to promote wakefulness. read more here.
Keywords: neurons medial; control wakefulness; glutamate neurons; septum control ... See more keywords
A Non-canonical Reticular-Limbic Central Auditory Pathway via Medial Septum Contributes to Fear Conditioning
Sign Up to like & getrecommendations! Published in 2018 at "Neuron"
DOI: 10.1016/j.neuron.2017.12.010
Abstract: In the mammalian brain, auditory information is known to be processed along a central ascending pathway leading to auditory cortex (AC). Whether there exist any major pathways beyond this canonical auditory neuraxis remains unclear. In… read more here.
Keywords: fear conditioning; auditory pathway; non canonical; pathway ... See more keywords
Medial septum modulates hippocampal gamma activity and prepulse inhibition in an N-methyl-d-aspartate receptor antagonist model of schizophrenia
Sign Up to like & getrecommendations! Published in 2018 at "Schizophrenia Research"
DOI: 10.1016/j.schres.2017.07.053
Abstract: We reviewed the participation of the septohippocampal system in an animal model of schizophrenia that was acutely induced by systemic injection of an N-methyl-d-aspartate (NMDA) receptor antagonist such as phencyclidine, MK-801 and ketamine. The NMDA… read more here.
Keywords: receptor antagonist; hippocampal gamma; model schizophrenia; receptor ... See more keywords
Neurokinin receptor mechanisms in forebrain medial septum modulate nociception in the formalin model of inflammatory pain
Sign Up to like & getrecommendations! Published in 2021 at "Scientific Reports"
DOI: 10.1038/s41598-021-03661-6
Abstract: The present study has explored the hypothesis that neurokinin1 receptors (NK1Rs) in medial septum (MS) modulate nociception evoked on hind paw injection of formalin. Indeed, the NK1Rs in MS are localized on cholinergic neurons which… read more here.
Keywords: medial septum; modulate nociception; septum; formalin ... See more keywords
Evidence supporting deep brain stimulation of the medial septum in the treatment of temporal lobe epilepsy
Sign Up to like & getrecommendations! Published in 2022 at "Epilepsia"
DOI: 10.1111/epi.17326
Abstract: Electrical brain stimulation has become an essential treatment option for more than one third of epilepsy patients who are resistant to pharmacological therapy and are not candidates for surgical resection. However, currently approved stimulation paradigms… read more here.
Keywords: medial septum; temporal lobe; stimulation; epilepsy ... See more keywords
Optogenetic activation of septal inhibitory cells abates focal seizures.
Sign Up to like & getrecommendations! Published in 2023 at "Journal of neurophysiology"
DOI: 10.1152/jn.00111.2023
Abstract: Emerging evidence suggest that the medial septum can control seizures occurring in focal epileptic disorders, thus representing a therapeutic target. Therefore, we investigated whether continuous optogenetic activation of inhibitory parvalbumin-positive (PV) interneurons in the medial… read more here.
Keywords: optogenetic activation; day; medial septum; inhibitory ... See more keywords
To Stop the Seizure, You Must Become the Seizure: Closed-Loop Stimulation Phase Locked to Seizure Waves Disrupts Kindled Seizures While Open-Loop Stimulation Fails
Sign Up to like & getrecommendations! Published in 2021 at "Epilepsy Currents"
DOI: 10.1177/15357597211014187
Abstract: Closed-Loop Stimulation of the Medial Septum Terminates Epileptic Seizures Takeuchi Y, Harangozó M, Pedraza L, Földi T, Kozák G, Li Q, Berényi A. Brain. 2021;144(3):885-908. doi:10.1093/brain/awaa450 Temporal lobe epilepsy with distributed hippocampal seizure foci is… read more here.
Keywords: loop stimulation; stimulation; medial septum; seizure ... See more keywords
Medial Septum Modulates Consciousness and Psychosis-Related Behaviors Through Hippocampal Gamma Activity
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Neural Circuits"
DOI: 10.3389/fncir.2022.895000
Abstract: Abnormally high-amplitude hippocampal gamma activity (30–100 Hz) in behaving animals is seen after a hippocampal seizure, following injection of phencyclidine (PCP) or ketamine, and transiently in a delirium stage during induction of general anesthesia. High-amplitude… read more here.
Keywords: hippocampal gamma; gamma activity; medial septum; gamma ... See more keywords