Functionalized 1,3-Diaminotruxillic Acids by Pd-Mediated C-H Activation and [2+2]-Photocycloaddition of 5(4H )-Oxazolones
Sign Up to like & getrecommendations! Published in 2019 at "European Journal of Inorganic Chemistry"
DOI: 10.1002/ejic.201900548
Abstract: C. C. and E. P. U. thank the Gobierno de Aragon–Fondo Social Europeo (Spain, reference group Aminoacidos y Peptidos E19_17R) for financial support and the Servicio General de Apoyo a la Investigacion–SAI, Universidad de Zaragoza.… read more here.
Keywords: activation; functionalized diaminotruxillic; activation photocycloaddition; mediated activation ... See more keywords
Dehydroandrographolide targets CD300f and negatively regulated MRGPRX2‐induced pseudo‐allergic reaction
Sign Up to like & getrecommendations! Published in 2022 at "Phytotherapy Research"
DOI: 10.1002/ptr.7445
Abstract: Mas‐related G protein‐coupled receptor X2 (MRGPRX2) mediates mast cells (MCs) activation, which is a key target for the treatment of allergic diseases. However, there are few drugs targeting MRGPRX2. Leukocyte mono‐immunoglobulin‐like receptor 3 (CD300f) is… read more here.
Keywords: negatively regulated; pseudo allergic; regulated mrgprx2; mrgprx2 ... See more keywords
Extracellular H+ Ions are a Novel Signal for Tyrosine Hydroxylase Activation in Catecholaminergic Cells.
Sign Up to like & getrecommendations! Published in 2023 at "ACS chemical neuroscience"
DOI: 10.1021/acschemneuro.2c00696
Abstract: Tyrosine hydroxylase catalyzes the rate-limiting step in the catecholamine biosynthetic pathway. Short-term TH activity is proposed to be regulated by the phosphorylation/dephosphorylation of regulatory domains Ser 40, 31, and/or 19 in response to membrane depolarization… read more here.
Keywords: tyrosine hydroxylase; novel signal; mediated activation; extracellular ions ... See more keywords
Macrophage migration inhibitory factor regulates TLR4 expression and modulates TCR/CD3-mediated activation in CD4+ T lymphocytes
Sign Up to like & getrecommendations! Published in 2019 at "Scientific Reports"
DOI: 10.1038/s41598-019-45260-6
Abstract: Toll-like receptor 4 (TLR4) is involved in CD4+ T lymphocyte-mediated pathologies. Here, we demonstrate that CD4+ T lymphocytes express functional TLR4 that contributes to their activation, proliferation and cytokine secretion. In addition, we demonstrate that… read more here.
Keywords: cd4 lymphocytes; tcr cd3; mediated activation; cd3 mediated ... See more keywords
Antibody mediated activation of natural killer cells in malaria exposed pregnant women
Sign Up to like & getrecommendations! Published in 2021 at "Scientific Reports"
DOI: 10.1038/s41598-021-83093-4
Abstract: Immune effector responses against Plasmodium falciparum include antibody-mediated activation of innate immune cells, which can induce Fc effector functions, including antibody-dependent cellular cytotoxicity, and the secretion of cytokines and chemokines. These effector functions are regulated… read more here.
Keywords: placental malaria; antibody; pregnant women; mediated activation ... See more keywords
Organometallo-macrocycle assembled through dialumane-mediated C-H activation of pyridines.
Sign Up to like & getrecommendations! Published in 2021 at "Chemical communications"
DOI: 10.1039/d1cc00318f
Abstract: Dialumane 1 reacts with pyridines at elevated temperatures through regioselective reductive dehydrogenation of 4-H, affording a unique hexanuclear Al(iii) macrocycle [{LAl(pyridyl)}6], which represents the first dialumane-mediated C-H activation of Py and may suggest a new… read more here.
Keywords: dialumane; organometallo macrocycle; mediated activation; activation ... See more keywords
Ras-Mediated Activation of the Raf Family Kinases.
Sign Up to like & getrecommendations! Published in 2019 at "Cold Spring Harbor perspectives in medicine"
DOI: 10.1101/cshperspect.a033746
Abstract: The extracellular signal-regulated kinase (ERK) cascade comprised of the Raf, MEK, and ERK protein kinases constitutes a key effector cascade used by the Ras GTPases to relay signals regulating cell growth, survival, proliferation, and differentiation.… read more here.
Keywords: activation raf; ras mediated; raf activation; raf family ... See more keywords
Structure‐function of anticoagulant TIX‐5, the inhibitor of factor Xa‐mediated FV activation
Sign Up to like & getrecommendations! Published in 2021 at "Journal of Thrombosis and Haemostasis"
DOI: 10.1111/jth.15329
Abstract: The prothrombinase complex consists of factors Xa (FXa) and Va (FVa) on an anionic phospholipid surface and converts prothrombin into thrombin. Both coagulation factors require activation before complex assembly. We recently identified TIX‐5, a unique… read more here.
Keywords: anticoagulant tix; function anticoagulant; mediated activation; activation ... See more keywords
Axl-mediated activation of TBK1 drives epithelial plasticity in pancreatic cancer.
Sign Up to like & getrecommendations! Published in 2019 at "JCI insight"
DOI: 10.1172/jci.insight.126117
Abstract: Pancreatic ductal adenocarcinoma (PDA) is characterized by an activating mutation in KRAS. Direct inhibition of KRAS through pharmacological means remains a challenge; however, targeting key KRAS effectors has therapeutic potential. We investigated the contribution of… read more here.
Keywords: epithelial plasticity; axl; tbk1; mediated activation ... See more keywords
Schisandrol B and schisandrin B inhibit TGFβ1-mediated NF-κB activation via a Smad-independent mechanism
Sign Up to like & getrecommendations! Published in 2018 at "Oncotarget"
DOI: 10.18632/oncotarget.23213
Abstract: Aberrant transforming growth factor β1 (TGFβ1) signaling plays a pathogenic role in the development of vascular fibrosis. We have reported that Schisandra chinensis fruit extract (SCE), which has been used as a traditional oriental medicine,… read more here.
Keywords: smad independent; tgf; independent mechanism; mediated activation ... See more keywords
New perspectives on the regulation of germinal center reaction via αvβ8- mediated activation of TGFβ
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Immunology"
DOI: 10.3389/fimmu.2022.942468
Abstract: Transforming growth factor-β (TGFβ) is a long-known modulator of immune responses but has seemingly contradictory effects on B cells. Among cytokines, TGFβ has the particularity of being produced and secreted in a latent form and… read more here.
Keywords: reaction; mediated activation; germinal center; tgf ... See more keywords