Immune-mediated adverse effects of immune-checkpoint inhibitors and their management in cancer.
Sign Up to like & getrecommendations! Published in 2020 at "Immunology letters"
DOI: 10.1016/j.imlet.2020.02.008
Abstract: Within the past decade, immune-checkpoint inhibitors (ICPIs), including anti-programmed cell death 1 (PD-1), anti-programmed cell death 1 ligand 1 (PD-L1), and anti-cytotoxic T lymphocyte antigen 4 (CTLA-4) antibodies, are undoubtfully the most remarkable advances in… read more here.
Keywords: immune checkpoint; mediated adverse; checkpoint inhibitors; immune mediated ... See more keywords
The role of acetone in the [omim][BF4]-mediated adverse effects on tissues of mussels, human lymphocytes and the fruit fly Drosophila melanogaster.
Sign Up to like & getrecommendations! Published in 2017 at "Journal of hazardous materials"
DOI: 10.1016/j.jhazmat.2017.03.050
Abstract: The present study investigated [omim][BF4]-mediated adverse effects on biological models widely used in toxicological studies. Specifically, mussels of the genus Mytilus, human lymphocytes and fruit flies of the species Drosophila melanogaster, were exposed to [omim][BF4]… read more here.
Keywords: mediated adverse; acetone; bf4; adverse effects ... See more keywords
HLA Allele-Restricted Immune-Mediated Adverse Drug Reactions: Framework for Genetic Prediction.
Sign Up to like & getrecommendations! Published in 2021 at "Annual review of pharmacology and toxicology"
DOI: 10.1146/annurev-pharmtox-052120-014115
Abstract: Human leukocyte antigen (HLA) is a hallmark genetic marker for the prediction of certain immune-mediated adverse drug reactions (ADRs). Numerous basic and clinical research studies have provided the evidence base to push forward the clinical… read more here.
Keywords: mediated adverse; hla; drug; pharmacology ... See more keywords
PD-1 Inhibitors: Safety of Use and Management of Immune-Mediated Adverse Reactions in Patients With Head and Neck Cancer.
Sign Up to like & getrecommendations! Published in 2019 at "Clinical journal of oncology nursing"
DOI: 10.1188/19.cjon.627-638
Abstract: BACKGROUND Treatment of patients with recurrent or metastatic squamous cell carcinoma of the head and neck (SCCHN) with programmed cell death protein 1 (PD-1) inhibitors has been associated with risk of developing immune-mediated adverse reactions… read more here.
Keywords: mediated adverse; management; immune mediated; adverse reactions ... See more keywords
Association between immune-mediated adverse events and efficacy in metastatic non-small-cell lung cancer patients treated with durvalumab and tremelimumab
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Immunology"
DOI: 10.3389/fimmu.2022.1026964
Abstract: Purpose Immune-mediated adverse events (imAEs) may be associated with response to immune checkpoint inhibitors. We assessed the relationship between imAE development and efficacy in metastatic non-small-cell lung cancer patients treated with durvalumab (anti-programmed cell death… read more here.
Keywords: cell; immune mediated; mediated adverse; patients treated ... See more keywords