Oxidative stress mediated anti-leishmanial activity of endoperoxides represent a new therapeutic strategy in Leishmaniasis
Sign Up to like & getrecommendations! Published in 2018 at "Free Radical Biology and Medicine"
DOI: 10.1016/j.freeradbiomed.2018.04.537
Abstract: Endoperoxides kill malaria parasites via cleavage of their endoperoxide bridge by heme or iron, leading to generation of cytotoxic oxygen-centered radicals. In view of the impaired anti-oxidant defense and high iron content of Leishmania parasites,… read more here.
Keywords: therapeutic strategy; activity; stress mediated; mediated anti ... See more keywords
In vitro evaluation of the involvement of Nrf2 in maslinic acid-mediated anti-inflammatory effects in atheroma pathogenesis.
Sign Up to like & getrecommendations! Published in 2021 at "Life sciences"
DOI: 10.1016/j.lfs.2021.119658
Abstract: AIMS Maslinic acid (MA) is a naturally occurring pentacyclic triterpene known to exert cardioprotective effects. This study aims to investigate the involvement of nuclear factor erythroid 2-related factor 2 (Nrf2) for MA-mediated anti-inflammatory effects in… read more here.
Keywords: anti inflammatory; expression; thp macrophages; inflammatory effects ... See more keywords
Abstract 669: Immunophenotyping of human brain tumors reveals myeloid cell mediated anti-glioma axis
Sign Up to like & getrecommendations! Published in 2023 at "Cancer Research"
DOI: 10.1158/1538-7445.am2023-669
Abstract: Gliomas are recalcitrant brain tumors. Differential tumor immune reactivity contributes to survival advantage of isocitrate dehydrogenase-mutant (IDHmut) over wild-type (IDHwt) gliomas. Despite this correlative pattern of immunity and survival, only a limited view of a… read more here.
Keywords: cell; anti glioma; mediated anti; brain tumors ... See more keywords
Venetoclax enhances T cell-mediated anti-leukemic activity by increasing ROS production.
Sign Up to like & getrecommendations! Published in 2021 at "Blood"
DOI: 10.1182/blood.2020009081
Abstract: Venetoclax, a Bcl-2 inhibitor, in combination with the hypomethylating agent, Azacytidine, achieves complete response with or without count recovery in approximately 70% of treatment-naïve elderly patients unfit for conventional intensive chemotherapy. However, the mechanism of… read more here.
Keywords: venetoclax; cell mediated; enhances cell; venetoclax enhances ... See more keywords
Sorafenib Induces Apoptosis and Inhibits NF-κB-mediated Anti-apoptotic and Metastatic Potential in Osteosarcoma Cells
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DOI: 10.21873/anticanres.14882
Abstract: Background/Aim: Sorafenib, an oral multi-kinase inhibitor, has been shown to improve the outcome of patients with osteosarcoma (OS). However, the anti-OS effect and mechanism of sorafenib has not yet been fully understood. The main purpose… read more here.
Keywords: apoptotic metastatic; anti apoptotic; sorafenib; metastatic potential ... See more keywords
Nrf2-mediated anti-inflammatory polarization of macrophages as therapeutic targets for osteoarthritis
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Immunology"
DOI: 10.3389/fimmu.2022.967193
Abstract: Macrophages are the most abundant immune cells within the synovial joints, and also the main innate immune effector cells triggering the initial inflammatory responses in the pathological process of osteoarthritis (OA). The transition of synovial… read more here.
Keywords: mediated anti; signaling pathway; inflammatory polarization; anti inflammatory ... See more keywords