Recombinant adenovirus expressing the fusion protein PD1PVR improves CD8+ T cell-mediated antitumor efficacy with long-term tumor-specific immune surveillance in hepatocellular carcinoma.
Sign Up to like & getrecommendations! Published in 2021 at "Cellular oncology"
DOI: 10.1007/s13402-021-00633-w
Abstract: PURPOSE Treatment-associated upregulation of suppressive checkpoints and a lack of costimulatory signals compromise the antitumor efficacy of oncolytic virus immunotherapy. Therefore, we aimed to identify highly effective therapeutic targets to provide a proof-of-principle for immune… read more here.
Keywords: hepatocellular carcinoma; antitumor efficacy; mediated antitumor; efficacy ... See more keywords
EBV-upregulated B7-H3 inhibits NK cell-mediated antitumor function and contributes to nasopharyngeal carcinoma progression.
Sign Up to like & getrecommendations! Published in 2023 at "Cancer immunology research"
DOI: 10.1158/2326-6066.cir-22-0374
Abstract: Nasopharyngeal carcinoma (NPC) is an Epstein-Barr virus (EBV)-associated epithelial malignancy characterized by the presence of prominent infiltration of lymphocytes, including natural killer (NK) cells. Although NK cells can directly target EBV-infected tumor cells without restriction… read more here.
Keywords: nasopharyngeal carcinoma; cell; function; mediated antitumor ... See more keywords
Ultrasound-guided radiofrequency ablation enhances natural killer-mediated antitumor immunity against liver cancer
Sign Up to like & getrecommendations! Published in 2018 at "Oncology Letters"
DOI: 10.3892/ol.2018.8231
Abstract: For patients with liver cancer who are not sufficiently fit for surgical resection, radiofrequency ablation (RFA) is an effective and low risk treatment modality; however, the mechanism underlying this procedure is not fully understood. In… read more here.
Keywords: mediated antitumor; antitumor immunity; natural killer; cancer ... See more keywords