Microenvironmental Self‐Optimizing HOFs Biocatalysts for Boosting Disulfidptosis‐Mediated Antitumor Immunotherapy
Sign Up to like & getrecommendations! Published in 2025 at "Advanced Functional Materials"
DOI: 10.1002/adfm.202512644
Abstract: Disulfidptosis, a novel programmed cell death mechanism triggered by glucose deprivation in solute carrier family 7 member 11 (SLC7A11)‐overexpressing tumors, facilitates the release of tumor‐associated antigens (TAAs) and activates immune responses, providing a new strategy… read more here.
Keywords: mediated antitumor; disulfidptosis; immunotherapy; disulfidptosis mediated ... See more keywords
Recombinant adenovirus expressing the fusion protein PD1PVR improves CD8+ T cell-mediated antitumor efficacy with long-term tumor-specific immune surveillance in hepatocellular carcinoma.
Sign Up to like & getrecommendations! Published in 2021 at "Cellular oncology"
DOI: 10.1007/s13402-021-00633-w
Abstract: PURPOSE Treatment-associated upregulation of suppressive checkpoints and a lack of costimulatory signals compromise the antitumor efficacy of oncolytic virus immunotherapy. Therefore, we aimed to identify highly effective therapeutic targets to provide a proof-of-principle for immune… read more here.
Keywords: hepatocellular carcinoma; antitumor efficacy; mediated antitumor; efficacy ... See more keywords
L-Tetrahydropalmatine synergizes cytotoxic CD8+ T mediated antitumor and ferroptosis in gastric cancer
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DOI: 10.1038/s41420-025-02825-x
Abstract: L-Tetrahydropalmatine (L-THP) is an isoquinoline alkaloid derived from the traditional Chinese herb Corydalis (genus Corydalis), particularly its analgesic and sedative effects. The in-depth function of L-THP on gastric cancer (GC) immune escape is still unclear.… read more here.
Keywords: mediated antitumor; cd8; synergizes cytotoxic; gastric cancer ... See more keywords
Caerin 1.1/1.9-mediated antitumor immunity depends on IFNAR-Stat1 signalling of tumour infiltrating macrophage by autocrine IFNα and is enhanced by CD47 blockade
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DOI: 10.1038/s41598-025-87687-0
Abstract: Previously, we demonstrated that natural host-defence peptide caerin 1.1/caerin 1.9 (F1/F3) increases the efficacy of anti-PD-1 and therapeutic vaccine, in a HPV16 + TC-1 tumour model, but the anti-tumor mechanism of F1/F3 is still unclear. In this… read more here.
Keywords: mediated antitumor; cd47 blockade; caerin; tumour ... See more keywords
LILRB2 blockade facilitates macrophage repolarization and enhances T cell-mediated antitumor immunity
Sign Up to like & getrecommendations! Published in 2025 at "Journal for Immunotherapy of Cancer"
DOI: 10.1136/jitc-2024-010012
Abstract: Background Immune checkpoint inhibitors have revolutionized the treatment of solid tumors, enhancing clinical outcomes by releasing T cells from inhibitory effects of receptors like programmed cell death protein 1 (PD-1). Despite these advancements, achieving durable… read more here.
Keywords: mediated antitumor; lilrb2; cell; cell mediated ... See more keywords
EBV-upregulated B7-H3 inhibits NK cell-mediated antitumor function and contributes to nasopharyngeal carcinoma progression.
Sign Up to like & getrecommendations! Published in 2023 at "Cancer immunology research"
DOI: 10.1158/2326-6066.cir-22-0374
Abstract: Nasopharyngeal carcinoma (NPC) is an Epstein-Barr virus (EBV)-associated epithelial malignancy characterized by the presence of prominent infiltration of lymphocytes, including natural killer (NK) cells. Although NK cells can directly target EBV-infected tumor cells without restriction… read more here.
Keywords: nasopharyngeal carcinoma; cell; function; mediated antitumor ... See more keywords
Ultrasound-guided radiofrequency ablation enhances natural killer-mediated antitumor immunity against liver cancer
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DOI: 10.3892/ol.2018.8231
Abstract: For patients with liver cancer who are not sufficiently fit for surgical resection, radiofrequency ablation (RFA) is an effective and low risk treatment modality; however, the mechanism underlying this procedure is not fully understood. In… read more here.
Keywords: mediated antitumor; antitumor immunity; natural killer; cancer ... See more keywords