The Endoplasmic Reticulum ATP13A1 is Essential for MAVS‐Mediated Antiviral Innate Immunity
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DOI: 10.1002/advs.202203831
Abstract: RIG‐I‐MAVS signaling pathway is essential for efficient innate immune response against virus infection. Though many components have been identified in RIG‐I pathway and it can be partially reconstituted in vitro, detailed mechanisms involved in cells… read more here.
Keywords: endoplasmic reticulum; antiviral innate; mediated antiviral; mavs ... See more keywords
Sec13 is a positive regulator of VISA-mediated antiviral signaling
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DOI: 10.1007/s11262-018-1581-0
Abstract: Viral infection triggers the innate antiviral immune response that rapidly produces type I interferons in most cell types to combat viruses invading. Upon viral infection, the cytoplasmic RNA sensors RIG-I/MDA5 recognize viral RNA, and then… read more here.
Keywords: sec13 positive; visa mediated; antiviral signaling; mediated antiviral ... See more keywords
RNAi-mediated antiviral immunity in insects and their possible application.
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DOI: 10.1016/j.coviro.2018.10.004
Abstract: Antiviral RNA interference (RNAi) in insects is known for some time. Previously, data from the model organism Drosophila was lightly transferred to other insects. However, since more research is performed on other insects, both similarities… read more here.
Keywords: insects; antiviral immunity; mediated antiviral; rnai ... See more keywords
Arginine methyltransferase PRMT5 negatively regulates cGAS-mediated antiviral immune response
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DOI: 10.1126/sciadv.abc1834
Abstract: PRMT5 directly induces methylation of cGAS and inhibits cGAS-mediated antiviral immunity. Cyclic GMP-AMP synthase (cGAS) functions as an essential DNA sensor, which senses the cytoplasmic double-stranded DNA and activates the antiviral response. However, the posttranslational… read more here.
Keywords: cgas; response; mediated antiviral; cgas mediated ... See more keywords
Human Respiratory Syncytial Virus NS 1 Targets TRIM25 to Suppress RIG-I Ubiquitination and Subsequent RIG-I-Mediated Antiviral Signaling
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DOI: 10.3390/v10120716
Abstract: Respiratory syncytial virus (RSV) causes severe acute lower respiratory tract disease. Retinoic acid-inducible gene-I (RIG-I) serves as an innate immune sensor and triggers antiviral responses upon recognizing viral infections including RSV. Since tripartite motif-containing protein… read more here.
Keywords: rig; mediated antiviral; rig ubiquitination; antiviral signaling ... See more keywords
Pseudorabies Virus Tegument Protein UL13 Suppresses RLR-Mediated Antiviral Innate Immunity through Regulating Receptor Transcription
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DOI: 10.3390/v14071465
Abstract: Pseudorabies virus (PRV) has evolved various strategies to escape host antiviral immune responses. However, it remains unclear whether and how PRV-encoded proteins modulate the RIG-I-like receptor (RLR)-mediated signals for immune evasion. Here, we show that… read more here.
Keywords: rlr mediated; transcription; rig mda5; mediated antiviral ... See more keywords
Interferon-Stimulated Gene 15 Knockout in Mice Impairs IFNα-Mediated Antiviral Activity
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DOI: 10.3390/v14091862
Abstract: Type I interferon (IFN) plays an important role in the host defense against viral infection by inducing expression of interferon-stimulated genes (ISGs). In a previous study, we found that porcine interferon-stimulated gene 15 (ISG15) exhibited… read more here.
Keywords: ifn mediated; isg15 mice; mediated antiviral; mice ... See more keywords