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   Articles with "mediated antiviral" as a keyword



The Endoplasmic Reticulum ATP13A1 is Essential for MAVS‐Mediated Antiviral Innate Immunity

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recommendations! Published in 2022 at "Advanced Science"

DOI: 10.1002/advs.202203831

Abstract: RIG‐I‐MAVS signaling pathway is essential for efficient innate immune response against virus infection. Though many components have been identified in RIG‐I pathway and it can be partially reconstituted in vitro, detailed mechanisms involved in cells… read more here.

Keywords: endoplasmic reticulum; antiviral innate; mediated antiviral; mavs ... See more keywords

Sec13 is a positive regulator of VISA-mediated antiviral signaling

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recommendations! Published in 2018 at "Virus Genes"

DOI: 10.1007/s11262-018-1581-0

Abstract: Viral infection triggers the innate antiviral immune response that rapidly produces type I interferons in most cell types to combat viruses invading. Upon viral infection, the cytoplasmic RNA sensors RIG-I/MDA5 recognize viral RNA, and then… read more here.

Keywords: sec13 positive; visa mediated; antiviral signaling; mediated antiviral ... See more keywords
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RNAi-mediated antiviral immunity in insects and their possible application.

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recommendations! Published in 2018 at "Current opinion in virology"

DOI: 10.1016/j.coviro.2018.10.004

Abstract: Antiviral RNA interference (RNAi) in insects is known for some time. Previously, data from the model organism Drosophila was lightly transferred to other insects. However, since more research is performed on other insects, both similarities… read more here.

Keywords: insects; antiviral immunity; mediated antiviral; rnai ... See more keywords

TRBP modulates RLR signaling by inhibiting PKR-mediated antiviral stress granule formation

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recommendations! Published in 2025 at "Scientific Reports"

DOI: 10.1038/s41598-025-07121-3

Abstract: Stress granules (SGs) are dense aggregates of RNA and proteins that form in response to various cellular stresses. Virus-induced SGs, known as antiviral SGs (avSGs), play a crucial role in regulating retinoic acid-inducible gene I-like… read more here.

Keywords: trbp; stress; rna; avsg formation ... See more keywords

Black carp Nup93 negatively regulates IRF3- and IRF7-mediated antiviral immune response.

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recommendations! Published in 2025 at "Journal of immunology"

DOI: 10.1093/jimmun/vkaf270

Abstract: Nucleoporin 93 (Nup93), a key component of the nuclear pore complex, is involved in various cellular processes, such as immune signaling pathway. In mammals, Nup93 positively regulates the RLR signaling pathway by targeting TBK1 and… read more here.

Keywords: immune response; antiviral immune; carp; black carp ... See more keywords

Arginine methyltransferase PRMT5 negatively regulates cGAS-mediated antiviral immune response

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recommendations! Published in 2021 at "Science Advances"

DOI: 10.1126/sciadv.abc1834

Abstract: PRMT5 directly induces methylation of cGAS and inhibits cGAS-mediated antiviral immunity. Cyclic GMP-AMP synthase (cGAS) functions as an essential DNA sensor, which senses the cytoplasmic double-stranded DNA and activates the antiviral response. However, the posttranslational… read more here.

Keywords: cgas; response; mediated antiviral; cgas mediated ... See more keywords

Zebrafish phd1 enhances mavs-mediated antiviral responses in a hydroxylation-independent manner

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recommendations! Published in 2024 at "Journal of Virology"

DOI: 10.1128/jvi.01038-24

Abstract: ABSTRACT PHD1 is a member of the prolyl hydroxylase domain protein (PHD1–4) family, which plays a prominent role in the post-translational modification of its target proteins by hydroxylating proline residues. The best-characterized targets of PHD1… read more here.

Keywords: mavs; zebrafish phd1; phd1; mavs mediated ... See more keywords

Human Respiratory Syncytial Virus NS 1 Targets TRIM25 to Suppress RIG-I Ubiquitination and Subsequent RIG-I-Mediated Antiviral Signaling

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recommendations! Published in 2018 at "Viruses"

DOI: 10.3390/v10120716

Abstract: Respiratory syncytial virus (RSV) causes severe acute lower respiratory tract disease. Retinoic acid-inducible gene-I (RIG-I) serves as an innate immune sensor and triggers antiviral responses upon recognizing viral infections including RSV. Since tripartite motif-containing protein… read more here.

Keywords: rig; mediated antiviral; rig ubiquitination; antiviral signaling ... See more keywords

Pseudorabies Virus Tegument Protein UL13 Suppresses RLR-Mediated Antiviral Innate Immunity through Regulating Receptor Transcription

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recommendations! Published in 2022 at "Viruses"

DOI: 10.3390/v14071465

Abstract: Pseudorabies virus (PRV) has evolved various strategies to escape host antiviral immune responses. However, it remains unclear whether and how PRV-encoded proteins modulate the RIG-I-like receptor (RLR)-mediated signals for immune evasion. Here, we show that… read more here.

Keywords: rlr mediated; transcription; rig mda5; mediated antiviral ... See more keywords

Interferon-Stimulated Gene 15 Knockout in Mice Impairs IFNα-Mediated Antiviral Activity

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recommendations! Published in 2022 at "Viruses"

DOI: 10.3390/v14091862

Abstract: Type I interferon (IFN) plays an important role in the host defense against viral infection by inducing expression of interferon-stimulated genes (ISGs). In a previous study, we found that porcine interferon-stimulated gene 15 (ISG15) exhibited… read more here.

Keywords: ifn mediated; isg15 mice; mediated antiviral; mice ... See more keywords