Pinocembrin induces ER stress mediated apoptosis and suppresses autophagy in melanoma cells.
Sign Up to like & getrecommendations! Published in 2018 at "Cancer letters"
DOI: 10.1016/j.canlet.2018.05.026
Abstract: Melanoma, one of the toughest tumors to treat, features high metastasis and high lethality. Pinocembrin is a natural flavanone with versatile biological and pharmacological activities. Here, we evaluated the anti-tumor effects of pinocembrin against melanoma… read more here.
Keywords: melanoma; apoptosis; autophagy melanoma; melanoma cells ... See more keywords
Potent half-sandwich Ru(Ⅱ) N^N (aryl-BIAN) complexes: Lysosome-mediated apoptosis, in vitro and in vivo anticancer activities.
Sign Up to like & getrecommendations! Published in 2020 at "European journal of medicinal chemistry"
DOI: 10.1016/j.ejmech.2020.112763
Abstract: Herein a new series of organometallic half-sandwich Ru(Ⅱ) complexes bearing aryl-BIAN chelating ligands with various electron-withdrawing and electron-donating substituents have been developed as theranostic agents. All the complexes display much higher anti-proliferative potency than the… read more here.
Keywords: lysosome mediated; aryl bian; apoptosis vitro; apoptosis ... See more keywords
NPD1 rapidly targets mitochondria-mediated apoptosis after acute injection protecting brain against ischemic injury
Sign Up to like & getrecommendations! Published in 2021 at "Experimental Neurology"
DOI: 10.1016/j.expneurol.2020.113495
Abstract: Mitochondria-related cell death pathways play a major role in ischemic brain injury. Thus, mitochondrial "protective" molecules could be considered for new therapeutic regimens. We recently reported that acute administration of docosahexaenoic acid (DHA) triglyceride lipid… read more here.
Keywords: mitochondria mediated; ischemic injury; brain; mediated apoptosis ... See more keywords
DRP-1-mediated apoptosis induces muscle degeneration in dystrophin mutants
Sign Up to like & getrecommendations! Published in 2018 at "Scientific Reports"
DOI: 10.1038/s41598-018-25727-8
Abstract: Mitochondria are double-membrane subcellular organelles with highly conserved metabolic functions including ATP production. Mitochondria shapes change continually through the combined actions of fission and fusion events rendering mitochondrial network very dynamic. Mitochondria are largely implicated… read more here.
Keywords: drp mediated; muscle degeneration; degeneration; mediated apoptosis ... See more keywords
Chronic Kidney Disease Exacerbates Myocardial Ischemia Reperfusion Injury: Role of Endoplasmic Reticulum Stress-Mediated Apoptosis
Sign Up to like & getrecommendations! Published in 2018 at "SHOCK"
DOI: 10.1097/shk.0000000000000970
Abstract: ABSTRACT Chronic kidney disease (CKD) is known to exacerbate myocardial ischemia reperfusion (IR) injury. However, the underlying mechanisms are still not well understood. Despite various strategies for cardioprotection, limited studies have been focused on the… read more here.
Keywords: stress mediated; mediated apoptosis; injury; ckd ... See more keywords
Recombinant Rv1654 protein of Mycobacterium tuberculosis induces mitochondria‐mediated apoptosis in macrophage
Sign Up to like & getrecommendations! Published in 2021 at "Microbiology and Immunology"
DOI: 10.1111/1348-0421.12880
Abstract: Mycobacterium tuberculosis contains diverse immunologically active components. This study investigated the biological function of a newly identified component, Rv1654, with the potential to induce apoptosis in macrophages. Recombinant Rv1654 induced macrophage apoptosis in a caspase‐9/3‐dependent… read more here.
Keywords: apoptosis; recombinant rv1654; rv1654; rv1654 induced ... See more keywords
Fas‐FasL interaction in cytotoxic T cell‐mediated vitiligo: The role of lesional expression of tumor necrosis factor‐α and interferon‐γ in Fas‐mediated melanocyte apoptosis
Sign Up to like & getrecommendations! Published in 2019 at "Experimental Dermatology"
DOI: 10.1111/exd.14053
Abstract: Vitiligo is an acquired skin depigmentation disorder resulting from the selective loss of epidermal melanocytes, and previous studies have suggested that a T lymphocyte‐mediated mechanism has a role in melanocyte loss. Although Fas‐Fas ligand (FasL)… read more here.
Keywords: apoptosis; fas fasl; expression; mediated apoptosis ... See more keywords
Notch signaling protects CD4 T cells from STING-mediated apoptosis during acute systemic inflammation
Sign Up to like & getrecommendations! Published in 2020 at "Science Advances"
DOI: 10.1126/sciadv.abc5447
Abstract: Notch or STING, which is in charge of CD4 T cell fate? Dysregulation of T cell apoptosis contributes to the pathogenesis of acute systemic inflammation–induced immunosuppression, as seen in sepsis and trauma. However, the regulatory… read more here.
Keywords: cd4 cells; sting mediated; apoptosis; notch ... See more keywords
Evodiamine suppresses the progression of non-small cell lung carcinoma via endoplasmic reticulum stress-mediated apoptosis pathway in vivo and in vitro
Sign Up to like & getrecommendations! Published in 2022 at "International Journal of Immunopathology and Pharmacology"
DOI: 10.1177/03946320221086079
Abstract: Background Evodiamine (EVO) is one of the major components isolated from Evodia rutaecarpa (Juss.). Recent studies have shown that EVO has an anti-cancer effect. However, the pharmacological mechanism by which EVO impacts cancer is still… read more here.
Keywords: cell; mediated apoptosis; apoptosis; tumor ... See more keywords
miR-103/107 promote ER stress-mediated apoptosis via targeting the Wnt3a/β-catenin/ATF6 pathway in preadipocytes
Sign Up to like & getrecommendations! Published in 2018 at "Journal of Lipid Research"
DOI: 10.1194/jlr.m082602
Abstract: Both miR-103 and miR-107 have been demonstrated to restrain cell proliferation and regulate lipid metabolism and inflammation. However, the effects of miR-103/107 on preadipocyte apoptosis remain unknown. In the present research, we have investigated how… read more here.
Keywords: stress mediated; mir 103; 103 107; mediated apoptosis ... See more keywords
Restoration of the prolyl-hydroxylase domain protein-3 oxygen-sensing mechanism is responsible for regulation of HIF2α expression and induction of sensitivity of myeloma cells to hypoxia-mediated apoptosis
Sign Up to like & getrecommendations! Published in 2017 at "PLoS ONE"
DOI: 10.1371/journal.pone.0188438
Abstract: Multiple myeloma (MM) is an incurable disease of malignant plasma B-cells that infiltrate the bone marrow (BM), resulting in bone destruction, anemia, renal impairment and infections. Physiologically, the BM microenvironment is hypoxic and this promotes… read more here.
Keywords: myeloma; hif2; regulation hif2; mediated apoptosis ... See more keywords