Targeting EGFR‐mediated autophagy as a potential strategy for cancer therapy
Sign Up to like & getrecommendations! Published in 2018 at "International Journal of Cancer"
DOI: 10.1002/ijc.31398
Abstract: Autophagy is a naturally occurring programed cellular catabolic process stimulated by cellular stress for energy homeostasis maintenance and elimination of harmful substances. It mostly works as pro‐survival mechanism but on the other hand deregulation of… read more here.
Keywords: mediated autophagy; signaling pathway; cell death; cancer ... See more keywords
Investigation through naphtho[2,3‐a]pyrene on mutated EGFR mediated autophagy in NSCLC: Cellular model system unleashing therapeutic potential
Sign Up to like & getrecommendations! Published in 2024 at "IUBMB Life"
DOI: 10.1002/iub.2914
Abstract: Mutant epidermal growth factor receptor (EGFR) signaling has emerged as a key cause of carcinogenesis and therapy resistance in non‐small cell lung cancer (NSCLC), which continues to pose a serious threat to world health. In… read more here.
Keywords: egfr mediated; nsclc; model; naphtho pyrene ... See more keywords
Sohlh2 Promotes the Progression of Hepatocellular Carcinoma via TGM2‐Mediated Autophagy
Sign Up to like & getrecommendations! Published in 2024 at "Molecular Carcinogenesis"
DOI: 10.1002/mc.23832
Abstract: Liver cancer is the third leading cause of cancer‐related deaths worldwide, with hepatocellular carcinoma (HCC) accounting for 85% of liver cancer‐related deaths. Autophagy controls HCC cell growth, invasion, metastasis, drug resistance, and stemness. Spermatogenesis and… read more here.
Keywords: tgm2; hcc; via tgm2; hepatocellular carcinoma ... See more keywords
Polydatin Alleviates Septic Myocardial Injury by Promoting SIRT6-Mediated Autophagy
Sign Up to like & getrecommendations! Published in 2020 at "Inflammation"
DOI: 10.1007/s10753-019-01153-4
Abstract: Sepsis is a life-threatening condition. Polydatin (PD), a small natural compound from Polygonum cuspidatum , possesses antioxidant and anti-inflammatory properties. However, the protective mechanism of PD on sepsis-induced acute myocardial damage is still unclear. The… read more here.
Keywords: sepsis; sirt6 mediated; mediated autophagy; lps induced ... See more keywords
Naringenin Upregulates AMPK-Mediated Autophagy to Rescue Neuronal Cells From β-Amyloid (1–42) Evoked Neurotoxicity
Sign Up to like & getrecommendations! Published in 2020 at "Molecular Neurobiology"
DOI: 10.1007/s12035-020-01969-4
Abstract: Deposition of an amyloid-β peptide is one of the first events in the pathophysiology of Alzheimer’s disease (AD) and is clinically characterized by Aβ plaques, tau tangles, and behavioral impairments that lead to neuronal death.… read more here.
Keywords: neuronal cells; mediated autophagy; naringenin; evoked neurotoxicity ... See more keywords
FoxO1-mediated autophagy plays an important role in the neuroprotective effects of hydrogen in a rat model of vascular dementia
Sign Up to like & getrecommendations! Published in 2019 at "Behavioural Brain Research"
DOI: 10.1016/j.bbr.2018.05.023
Abstract: &NA; Vascular dementia (VD) is a heterogeneous group of brain disorders in which cognitive impairment is attributed to cerebrovascular pathologies. Autophagy, a self‐cannibalization mechanism, has been demonstrated to be involved in VD progression. Molecular hydrogen… read more here.
Keywords: effects hydrogen; mediated autophagy; vascular dementia; rat model ... See more keywords
Inhibition of chaperone-mediated autophagy prevents glucotoxicity in the Caenorhabditis elegans mev-1 mutant by activation of the proteasome.
Sign Up to like & getrecommendations! Published in 2017 at "Biochemical and biophysical research communications"
DOI: 10.1016/j.bbrc.2017.01.043
Abstract: Chronic hyperglycemia is a hallmark of diabetes mellitus and the main cause of diabetes-associated complications. Increased intracellular glucose levels lead to damaged proteins and in consequence disturb cellular proteostasis. As an important contributor to the… read more here.
Keywords: mev mutant; mediated autophagy; glucotoxicity; chaperone mediated ... See more keywords
Prolyl oligopeptidase acts as a link between chaperone-mediated autophagy and macroautophagy.
Sign Up to like & getrecommendations! Published in 2021 at "Biochemical pharmacology"
DOI: 10.1016/j.bcp.2021.114899
Abstract: The accumulation of aggregated α-synuclein (α-syn) has been identified as the primary component of Lewy bodies that are the pathological hallmarks of Parkinson's disease (PD). Several preclinical studies have shown α-syn aggregation, and particularly the… read more here.
Keywords: syn; kyp 2047; chaperone mediated; mediated autophagy ... See more keywords
Vangl2 limits chaperone-mediated autophagy to balance osteogenic differentiation in mesenchymal stem cells.
Sign Up to like & getrecommendations! Published in 2021 at "Developmental cell"
DOI: 10.1016/j.devcel.2021.06.011
Abstract: Lysosomes are the recycling center and nutrient signaling hub of the cell. Here, we show that lysosomes also control mesenchymal stem cell (MSC) differentiation by proteomic reprogramming. The chaperone-mediated autophagy (CMA) lysosome subgroup promotes osteogenesis,… read more here.
Keywords: vangl2; mediated autophagy; chaperone mediated; differentiation ... See more keywords
Transcription factor EB (TFEB)-mediated autophagy protects against ethyl carbamate-induced cytotoxicity.
Sign Up to like & getrecommendations! Published in 2019 at "Journal of hazardous materials"
DOI: 10.1016/j.jhazmat.2018.10.037
Abstract: Ethyl carbamate (EC) is thought to be a toxicant that widely exists in cigarette smoke and polluted air, as well as fermented food and alcoholic beverages. However, the mechanism and approach to treat hepatic damage… read more here.
Keywords: mediated autophagy; factor tfeb; transcription factor; tfeb mediated ... See more keywords
Glabridin inhibits osteoarthritis development by protecting chondrocytes against oxidative stress, apoptosis and promoting mTOR mediated autophagy.
Sign Up to like & getrecommendations! Published in 2021 at "Life sciences"
DOI: 10.1016/j.lfs.2020.118992
Abstract: Osteoarthritis (OA) is a common chronic degenerative disease that affects the elderly. Thus far, no pharmacological therapy approved by regulators has shown a convincing effect on OA. Glabridin, a small molecule, is a well-known and… read more here.
Keywords: mediated autophagy; apoptosis; glabridin; mtor mediated ... See more keywords