CRISPR-mediated BMP9 ablation promotes liver steatosis via the down-regulation of PPARĪ± expression
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DOI: 10.1126/sciadv.abc5022
Abstract: Hepatic cytokine BMP9 attenuates fatty liver by regulating the key lipid metabolism factor PPARĪ±. Obesity drives the development of nonalcoholic fatty liver disease (NAFLD) characterized by hepatic steatosis. Several bone morphogenetic proteins (BMPs) except BMP9… read more here.
Keywords: ppar; liver steatosis; mediated bmp9; ppar expression ... See more keywords