Puerarin promotes ABCA1-mediated cholesterol efflux and decreases cellular lipid accumulation in THP-1 macrophages.
Sign Up to like & getrecommendations! Published in 2017 at "European journal of pharmacology"
DOI: 10.1016/j.ejphar.2017.05.055
Abstract: It was reported that puerarin decreases the total cholesterol, low-density lipoprotein cholesterol (LDL-C), triglyceride (TG) and increases high-density lipoprotein cholesterol (HDL-C) level, but the underlying mechanism is unclear. This study was designed to determine whether… read more here.
Keywords: lipid accumulation; abca1 mediated; cholesterol; mediated cholesterol ... See more keywords
ApoCIII enrichment in HDL impairs HDL-mediated cholesterol efflux capacity
Sign Up to like & getrecommendations! Published in 2017 at "Scientific Reports"
DOI: 10.1038/s41598-017-02601-7
Abstract: Apolipoprotein CIII (apoCIII) has been reported to be tightly associated with triglyceride metabolism and the susceptibility to coronary artery disease (CAD). Besides, apoCIII has also been found to affect the anti-apoptotic effects of HDL. However,… read more here.
Keywords: mediated cholesterol; cholesterol efflux; hdl mediated; hdl ... See more keywords
Predictive value of HDL function in patients with coronary artery disease: relationship with coronary plaque characteristics and clinical events
Sign Up to like & getrecommendations! Published in 2022 at "Annals of Medicine"
DOI: 10.1080/07853890.2022.2063374
Abstract: Abstract Background HDL is endowed with several metabolic, vascular, and immunoinflammatory protective functions. Among them, a key property is to promote reverse cholesterol transport from cells back to the liver. The aim of this study… read more here.
Keywords: plaque; cholesterol efflux; mediated cholesterol; cholesterol ... See more keywords
Molecular mechanisms for ABCA1-mediated cholesterol efflux.
Sign Up to like & getrecommendations! Published in 2022 at "Cell cycle"
DOI: 10.1080/15384101.2022.2042777
Abstract: The maintenance of cellular cholesterol homeostasis is essential for normal cell function and viability. Excessive cholesterol accumulation is detrimental to cells and serves as the molecular basis of many diseases, such as atherosclerosis, Alzheimer's disease,… read more here.
Keywords: mediated cholesterol; abca1 mediated; cholesterol; cholesterol efflux ... See more keywords
Acid-Sensing Ion Channel 1/Calpain1 Activation Impedes Macrophage ATP-Binding Cassette Protein A1-Mediated Cholesterol Efflux Induced by Extracellular Acidification
Sign Up to like & getrecommendations! Published in 2021 at "Frontiers in Physiology"
DOI: 10.3389/fphys.2021.777386
Abstract: Background Extracellular acidification is a common feature of atherosclerotic lesions, and such an acidic microenvironment impedes ATP-binding cassette transporter A1 (ABCA1)-mediated cholesterol efflux and promotes atherogenesis. However, the underlying mechanism is still unclear. Acid-sensing ion… read more here.
Keywords: cholesterol efflux; mediated cholesterol; extracellular acidification;
HDL-like-Mediated Cell Cholesterol Trafficking in the Central Nervous System and Alzheimer’s Disease Pathogenesis
Sign Up to like & getrecommendations! Published in 2022 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms23169356
Abstract: The main aim of this work is to review the mechanisms via which high-density lipoprotein (HDL)-mediated cholesterol trafficking through the central nervous system (CNS) occurs in the context of Alzheimer’s disease (AD). Alzheimer’s disease is… read more here.
Keywords: cholesterol trafficking; hdl like; alzheimer disease; like mediated ... See more keywords