Rearrangement-mediated cis-regulatory alterations in advanced patient tumors reveal interactions with therapy
Sign Up to like & getrecommendations! Published in 2021 at "Cell reports"
DOI: 10.1016/j.celrep.2021.110023
Abstract: SUMMARY The global impact of somatic structural variants (SVs) on gene regulation in advanced tumors with complex treatment histories has been mostly uncharacterized. Here, using whole-genome and RNA sequencing from 570 recurrent or metastatic tumors,… read more here.
Keywords: mediated cis; rearrangement mediated; regulatory alterations; expression associations ... See more keywords
Titanium isopropoxide-mediated cis-selective synthesis of 3,4-substituted butyrolactones from CO2.
Sign Up to like & getrecommendations! Published in 2022 at "Chemical communications"
DOI: 10.1039/d2cc00446a
Abstract: We report a Ti(OiPr)4-mediated multicomponent reaction, which produces 3,4-substituted cis-δ-lactones from alkyl magnesium chloride, benzaldehyde and CO2. The key intermediate, titanacyclopropane, is formed in situ from Ti(OiPr)4 and a Grignard reagent, which enables 1,2-dinucleophilic reactivity… read more here.
Keywords: selective synthesis; synthesis substituted; mediated cis; isopropoxide mediated ... See more keywords