RORα is critical for mTORC1 activity in T cell-mediated colitis.
Sign Up to like & getrecommendations! Published in 2021 at "Cell reports"
DOI: 10.1016/j.celrep.2021.109682
Abstract: Inflammatory bowel disease (IBD) is multi-factorial chronic intestinal inflammation driven by pathogenic T cells, among which a large portion of patients are resistant to current anti-inflammatory regimes. The mechanisms underlying colitis pathogenicity and drug resistance are… read more here.
Keywords: mediated colitis; cell mediated; ror; mtorc1 ... See more keywords
Rationally designed bacterial consortia to treat chronic immune-mediated colitis and restore intestinal homeostasis
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DOI: 10.1038/s41467-021-23460-x
Abstract: Environmental factors, mucosal permeability and defective immunoregulation drive overactive immunity to a subset of resident intestinal bacteria that mediate multiple inflammatory conditions. GUT-103 and GUT-108, live biotherapeutic products rationally designed to complement missing or underrepresented… read more here.
Keywords: mediated colitis; chronic immune; colitis; immune mediated ... See more keywords
Characteristics and usefulness of transabdominal ultrasonography in immune-mediated colitis
Sign Up to like & getrecommendations! Published in 2022 at "Intestinal Research"
DOI: 10.5217/ir.2021.00166
Abstract: Background/Aims The usefulness of ultrasonography (US) in diseases of the gastrointestinal tract has been reported recently. This prospective study aimed to determine the features of US findings in immune-mediated colitis (IMC), an adverse event induced… read more here.
Keywords: ultrasonography; severity colitis; immune mediated; colitis ... See more keywords