CD48-expressing non-small-cell lung cancer cells are susceptible to natural killer cell-mediated cytotoxicity.
Sign Up to like & getrecommendations! Published in 2021 at "Archives of pharmacal research"
DOI: 10.1007/s12272-021-01365-z
Abstract: The susceptibility of cancer cells to natural killer (NK) cell-mediated cytotoxicity depends on the balance of activating and inhibitory ligands expressed on their surface. Although many types of cancer cells are killed by NK cells,… read more here.
Keywords: cancer; mediated cytotoxicity; cd48; cell mediated ... See more keywords
KIR Genotype and KIR Ligand Phenotypes That Improve the in Vitro Cord Blood or Autologous NK Cell Mediated Cytotoxicity Against Myeloma Marrow Plasma Cells
Sign Up to like & getrecommendations! Published in 2020 at "Biology of Blood and Marrow Transplantation"
DOI: 10.1016/j.bbmt.2019.12.395
Abstract: Instruction Killer Immunoglobulin-like Receptor (KIR) inhibition is known to influence the cytotoxic effects of natural killer (NK) cells against cancer cells. KIRs can be protective against relapse in myeloma (MM) (Gabriel et al Blood 2010,… read more here.
Keywords: kir; mediated cytotoxicity; cell mediated; blood ... See more keywords
Blended polar/nonpolar peptide conjugate interferes with human insulin amyloid-mediated cytotoxicity.
Sign Up to like & getrecommendations! Published in 2021 at "Bioorganic chemistry"
DOI: 10.1016/j.bioorg.2021.104899
Abstract: Insulin, a peptide hormone and a key regulator of blood glucose level, is routinely administered to type-I diabetic patients to achieve the required glycemic control. Insulin aggregation and ensuing amyloidosis has been observed at repeated… read more here.
Keywords: insulin; peptide conjugate; insulin amyloid; amyloid mediated ... See more keywords
Characterization of CD4+ T cell-mediated cytotoxicity in patients with multiple myeloma.
Sign Up to like & getrecommendations! Published in 2018 at "Cellular immunology"
DOI: 10.1016/j.cellimm.2018.02.009
Abstract: Multiple myeloma (MM) is an incurable cancer characterized by the development of malignant plasma cells. The CD8 T cell-mediated cytotoxicity is considered a major player in antitumor immunity, but in MM patients, the CD8 T… read more here.
Keywords: cd4 cells; cell mediated; cytotoxic cd4; mediated cytotoxicity ... See more keywords
MHC Class I Enables MSCs to Evade NK-Cell-Mediated Cytotoxicity and Exert Immunosuppressive Activity.
Sign Up to like & getrecommendations! Published in 2022 at "Stem cells"
DOI: 10.1093/stmcls/sxac043
Abstract: Allogeneic mesenchymal stem/stromal cells (MSCs) are frequently used in clinical trials due to their low expression of major histocompatibility complex (MHC) class I and lack of MHC class II. However, the levels of MHC classes… read more here.
Keywords: class; cell mediated; mhc class; mediated cytotoxicity ... See more keywords
NKG2D‐mediated cytotoxicity improves after primary surgery for high‐grade serous ovarian cancer
Sign Up to like & getrecommendations! Published in 2022 at "American Journal of Reproductive Immunology"
DOI: 10.1111/aji.13647
Abstract: Tumors compromise the patients’ immune system to promote their own survival. We have previously reported that HGSC exosomes play a central role, downregulating NKG2D cytotoxicity. Primary surgery's effect on tumor exosomes and NKG2D cytotoxicity in… read more here.
Keywords: cytotoxicity; mediated cytotoxicity; nkg2d mediated; primary surgery ... See more keywords
Evidence supporting a role for the immune checkpoint protein B7-H3 in NK cell-mediated cytotoxicity against AML.
Sign Up to like & getrecommendations! Published in 2022 at "Blood"
DOI: 10.1182/blood.2021014671
Abstract: We observed that the immune checkpoint protein B7-H3 is overexpressed in acute myeloid leukemia (AML) patients with poor treatment outcomes. Inhibition of B7-H3 expression or blocking of its activity using a novel monoclonal antibody (T-1A5)… read more here.
Keywords: antibody; aml; cell mediated; mediated cytotoxicity ... See more keywords
Avelumab, an IgG1 anti-PD-L1 Immune Checkpoint Inhibitor, Triggers NK Cell-Mediated Cytotoxicity and Cytokine Production Against Triple Negative Breast Cancer Cells
Sign Up to like & getrecommendations! Published in 2018 at "Frontiers in Immunology"
DOI: 10.3389/fimmu.2018.02140
Abstract: The standard treatment for Triple Negative Breast Cancer (TNBC) patients is cytotoxic chemotherapy, but it is restricted since the duration of response is usually short. Blocking the PD-1/PD-L1 pathway through monoclonal antibodies (mAbs) appears to… read more here.
Keywords: cell mediated; tnbc; cancer; mediated cytotoxicity ... See more keywords
Escaping Death: How Cancer Cells and Infected Cells Resist Cell-Mediated Cytotoxicity
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Immunology"
DOI: 10.3389/fimmu.2022.867098
Abstract: Cytotoxic lymphocytes are critical in our immune defence against cancer and infection. Cytotoxic T lymphocytes and Natural Killer cells can directly lyse malignant or infected cells in at least two ways: granule-mediated cytotoxicity, involving perforin… read more here.
Keywords: cytotoxicity; infected cells; death; mediated cytotoxicity ... See more keywords
Sialofucosylation Enables Platelet Binding to Myeloma Cells via P-Selectin and Suppresses NK Cell-Mediated Cytotoxicity
Sign Up to like & getrecommendations! Published in 2023 at "Cancers"
DOI: 10.3390/cancers15072154
Abstract: Simple Summary Platelet cloaking of tumor cells has been shown to play an important role in tumor metastasis and immune evasion. Multiple myeloma is a tumor of the plasma cells that colonizes different sites of… read more here.
Keywords: platelet binding; myeloma; myeloma cells; mediated cytotoxicity ... See more keywords
Granzymes: The Molecular Executors of Immune-Mediated Cytotoxicity
Sign Up to like & getrecommendations! Published in 2022 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms23031833
Abstract: Cytotoxic T lymphocytes, differentiated CD8+ T cells, use multiple mechanisms to mediate their function, including release of granules containing perforin and granzymes at target cells. Granzymes are a family of cytotoxic proteases that each act… read more here.
Keywords: molecular executors; granzyme; mediated cytotoxicity; executors immune ... See more keywords