Copper-Mediated Decarboxylative Coupling between Arylacetic Acids and 1,3-Dicarbonyl Compounds.
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DOI: 10.1021/acs.orglett.1c02897
Abstract: A copper-mediated decarboxylative coupling reaction between arylacetic acids and 1,3-dicarbonyl compounds was described. Significantly, methanocycloocta[b]indoles were also obtained by sequential intramolecular dehydrocyclization process in some cases. This protocol featured a broad substrate scope, simple operations,… read more here.
Keywords: acids dicarbonyl; mediated decarboxylative; copper mediated; dicarbonyl compounds ... See more keywords
Zinc-Mediated Decarboxylative Alkylation of Gem-difluoroalkenes.
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DOI: 10.1021/acs.orglett.8b01866
Abstract: An efficient and mild zinc-mediated decarboxylative alkylation of gem-difluoroalkenes with N-hydroxyphthalimide (NHP) esters, to give monofluoroalkenes in moderate to excellent yields with high Z-selectivity is reported. The reaction tolerates a broad range of functional groups… read more here.
Keywords: mediated decarboxylative; decarboxylative alkylation; gem difluoroalkenes; alkylation gem ... See more keywords
Zn-mediated decarboxylative carbagermatranation of aliphatic N-hydroxyphthalimide esters: evidence for an alkylzinc intermediate† †Electronic supplementary information (ESI) available. See DOI: 10.1039/c9sc04288a
Sign Up to like & getrecommendations! Published in 2020 at "Chemical Science"
DOI: 10.1039/c9sc04288a
Abstract: Alkyl carbagermatranes (Ge) synthesized from corresponding NHP esters was achieved. Mechanistic studies indicate that alkyl zinc intermediate was involved. read more here.
Keywords: mediated decarboxylative; carbagermatranation aliphatic; decarboxylative carbagermatranation; aliphatic hydroxyphthalimide ... See more keywords
Photoinduced ligand to metal charge transfer enabling cerium mediated decarboxylative alkylation of quinoxalin-2(1H)-ones.
Sign Up to like & getrecommendations! Published in 2022 at "Chemical communications"
DOI: 10.1039/d2cc00840h
Abstract: Here, we report the cerium-mediated decarboxylative alkylation of quinoxalin-2(1H)-ones utilizing feedstock carboxylic acids as a radical precursor via photoinduced-LMCT. This operationally simple protocol overcomes the limitation of the direct use of carboxylic acids to access… read more here.
Keywords: cerium mediated; alkylation quinoxalin; decarboxylative alkylation; quinoxalin ones ... See more keywords
Copper-mediated Decarboxylative Coupling of Benzamides with Potassium Malonate Monoesters via Directed C–H Cleavage
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DOI: 10.1246/cl.171212
Abstract: A copper-mediated decarboxylative coupling of benzamides with potassium malonate monoesters via 8-aminoquinoline-directed C-H cleavage has been developed. This reaction proceeds only by a copper salt to produce the corresponding alkylation products in good yields. read more here.
Keywords: benzamides potassium; coupling benzamides; mediated decarboxylative; copper mediated ... See more keywords