UPF1 reduces C9orf72 HRE-induced neurotoxicity in the absence of nonsense-mediated decay dysfunction
Sign Up to like & getrecommendations! Published in 2021 at "Cell reports"
DOI: 10.1016/j.celrep.2021.108925
Abstract: SUMMARY Multiple cellular pathways have been suggested to be altered by the C9orf72 GGGGCC (G4C2) hexanucleotide repeat expansion (HRE), including aspects of RNA regulation such as nonsense-mediated decay (NMD). Here, we investigate the role that… read more here.
Keywords: hre; mediated decay; neurotoxicity; upf1 reduces ... See more keywords
Engineered viral RNA decay intermediates to assess XRN1-mediated decay.
Sign Up to like & getrecommendations! Published in 2019 at "Methods"
DOI: 10.1016/j.ymeth.2018.11.019
Abstract: Both RNA synthesis and decay must be balanced within a cell to achieve proper gene expression. Additionally, modulation of RNA decay specifically offers the cell an opportunity to rapidly reshape the transcriptome in response to… read more here.
Keywords: mediated decay; rna; rna decay; biologically relevant ... See more keywords
A CRISPR-based Screen Links an Inhibitor of Nonsense-mediated Decay to eIF4A3 Target Engagement.
Sign Up to like & getrecommendations! Published in 2020 at "ACS chemical biology"
DOI: 10.1021/acschembio.0c00253
Abstract: Eukaryotic initiation factor (eIF) 4A3 is a DEAD-box RNA helicase and a core component of the exon-junction complex (EJC). The EJC marks the location of exon:exon junctions following the removal of introns by splicing and… read more here.
Keywords: crispr; mediated decay; eif4a3; engagement ... See more keywords
Escape from nonsense-mediated decay associates with anti-tumor immunogenicity
Sign Up to like & getrecommendations! Published in 2020 at "Nature Communications"
DOI: 10.1038/s41467-020-17526-5
Abstract: Frameshift insertion/deletions (fs-indels) are an infrequent but highly immunogenic mutation subtype. Although fs-indels are degraded through the nonsense-mediated decay (NMD) pathway, we hypothesise that some fs-indels escape degradation and elicit anti-tumor immune responses. Using allele-specific… read more here.
Keywords: escape; mediated decay; nmd escape; anti tumor ... See more keywords
RNA sequencing of synaptic and cytoplasmic Upf1-bound transcripts supports contribution of nonsense-mediated decay to epileptogenesis
Sign Up to like & getrecommendations! Published in 2017 at "Scientific Reports"
DOI: 10.1038/srep41517
Abstract: The nonsense mediated decay (NMD) pathway is a critical surveillance mechanism for identifying aberrant mRNA transcripts. It is unknown, however, whether the NMD system is affected by seizures in vivo and whether changes confer beneficial… read more here.
Keywords: mediated decay; status epilepticus; rna sequencing; nmd pathway ... See more keywords
2-5A-Mediated decay (2-5AMD): from antiviral defense to control of host RNA
Sign Up to like & getrecommendations! Published in 2022 at "Critical Reviews in Biochemistry and Molecular Biology"
DOI: 10.1080/10409238.2023.2181308
Abstract: Abstract Mammalian cells are exquisitely sensitive to the presence of double-stranded RNA (dsRNA), a molecule that they interpret as a signal of viral presence requiring immediate attention. Upon sensing dsRNA cells activate the innate immune… read more here.
Keywords: 5amd antiviral; decay 5amd; rna; mediated decay ... See more keywords
Nonsense-Mediated Decay Targeted RNA (ntRNA): Proposal of a ntRNA–miRNA–lncRNA Triple Regulatory Network Usable as Biomarker of Prognostic Risk in Patients with Kidney Cancer
Sign Up to like & getrecommendations! Published in 2022 at "Genes"
DOI: 10.3390/genes13091656
Abstract: The most prevalent subtype of renal cell carcinoma (RCC), kidney renal clear cell carcinoma (KIRC) may be associated with a poor prognosis in a high number of cases, with a stage-specific prognostic stratification currently in… read more here.
Keywords: nonsense mediated; network; decay targeted; mediated decay ... See more keywords