Alterations in ubiquitin‐mediated degradation of NaV1.5 can cause arrhythmia
Sign Up to like & getrecommendations! Published in 2020 at "Acta Physiologica"
DOI: 10.1111/apha.13459
Abstract: The voltage-gated sodium (NaV ) channel is required for cardiomyocyte function. In heart, its major, pore-forming, α-subunit is NaV 1.5, encoded by SCN5A, which maps to chromosome 3p21. The NaV channel plays a key role… read more here.
Keywords: cause arrhythmia; ubiquitin mediated; degradation nav1; alterations ubiquitin ... See more keywords
Target protein localization and its impact on PROTAC-mediated degradation.
Sign Up to like & getrecommendations! Published in 2022 at "Cell chemical biology"
DOI: 10.2139/ssrn.4006704
Abstract: Proteolysis-targeting chimeras (PROTACs) bring a protein of interest (POI) into spatial proximity of an E3 ubiquitin ligase, promoting POI ubiquitylation and proteasomal degradation. PROTACs rely on endogenous cellular machinery to mediate POI degradation, therefore the… read more here.
Keywords: poi; localization; mediated degradation; degradation ... See more keywords