Hydrogel-mediated delivery of microRNA-92a inhibitor polyplex nanoparticles induces localized angiogenesis.
Sign Up to like & getrecommendations! Published in 2021 at "Angiogenesis"
DOI: 10.1007/s10456-021-09778-6
Abstract: Localized stimulation of angiogenesis is an attractive strategy to improve the repair of ischemic or injured tissues. Several microRNAs (miRNAs) such as miRNA-92a (miR-92a) have been reported to negatively regulate angiogenesis in ischemic disease. To… read more here.
Keywords: angiogenesis; mediated delivery; lna 92a; 92a inhibitor ... See more keywords
Microneedle-mediated delivery of cosmeceutically relevant nucleoside and peptides in human skin: challenges and strategies for dermal delivery
Sign Up to like & getrecommendations! Published in 2019 at "Journal of Pharmaceutical Investigation"
DOI: 10.1007/s40005-019-00438-y
Abstract: BackgroundHighly specific biologically active nucleoside and small peptides, sub fragments of collagen, in specific sequences, have attracted increasing attention for their use in the cosmeceutical field. To be effective in improving the skin and treating… read more here.
Keywords: nucleoside peptides; microneedle mediated; mediated delivery; delivery ... See more keywords
Targeted inactivation of EPS8 using dendrimer‐mediated delivery of RNA interference
Sign Up to like & getrecommendations! Published in 2019 at "International Journal of Pharmaceutics"
DOI: 10.1016/j.ijpharm.2018.12.060
Abstract: Graphical abstract Figure. No Caption available. ABSTRACT We developed polyamidoamine dendrimers conjugated with epidermal growth factor (EGF) for use in receptor‐mediated delivery of therapeutics to cancer cells. Here, we demonstrate the utility of this approach… read more here.
Keywords: targeted inactivation; mediated delivery; eps8 using; inactivation eps8 ... See more keywords
RTB lectin-mediated delivery of lysosomal α-l-iduronidase mitigates disease manifestations systemically including the central nervous system.
Sign Up to like & getrecommendations! Published in 2018 at "Molecular genetics and metabolism"
DOI: 10.1016/j.ymgme.2017.11.013
Abstract: Mucopolysaccharidosis type I (MPS I) is a lysosomal disease resulting from deficiency in the α-L-iduronidase (IDUA) hydrolase and subsequent accumulation of glycosaminoglycan (GAG). Clinically, enzyme replacement therapy (ERT) with IDUA achieves negligible neurological benefits presumably… read more here.
Keywords: mediated delivery; idua; delivery; lectin ... See more keywords
Farnesyltransferase-Mediated Delivery of a Covalent Inhibitor Overcomes Alternative Prenylation to Mislocalize K-Ras.
Sign Up to like & getrecommendations! Published in 2017 at "ACS chemical biology"
DOI: 10.1021/acschembio.7b00374
Abstract: Mutationally activated Ras is one of the most common oncogenic drivers found across all malignancies, and its selective inhibition has long been a goal in both pharma and academia. One of the oldest and most… read more here.
Keywords: mediated delivery; alternative prenylation; covalent inhibitor; farnesyltransferase mediated ... See more keywords
Particle-mediated delivery of frataxin plasmid to a human sensory neuronal model of Friedreich's ataxia.
Sign Up to like & getrecommendations! Published in 2020 at "Biomaterials science"
DOI: 10.1039/c9bm01757g
Abstract: Increasing frataxin protein levels through gene therapy is envisaged to improve therapeutic outcomes for patients with Friedreich's ataxia (FRDA). A non-viral strategy that uses submicrometer-sized multilayered particles to deliver frataxin-encoding plasmid DNA affords up to… read more here.
Keywords: particle mediated; mediated delivery; friedreich ataxia; frataxin ... See more keywords
Comparison of partially and fully chemically-modified siRNA in conjugate-mediated delivery in vivo
Sign Up to like & getrecommendations! Published in 2018 at "Nucleic Acids Research"
DOI: 10.1093/nar/gky037
Abstract: Abstract Small interfering RNA (siRNA)-based drugs require chemical modifications or formulation to promote stability, minimize innate immunity, and enable delivery to target tissues. Partially modified siRNAs (up to 70% of the nucleotides) provide significant stabilization… read more here.
Keywords: fully chemically; mediated delivery; delivery; chemically modified ... See more keywords
Influence of Dose on Neutrophil-Mediated Delivery of Nanoparticles for Tumor-Targeting Therapy Strategies.
Sign Up to like & getrecommendations! Published in 2021 at "AAPS PharmSciTech"
DOI: 10.1208/s12249-021-01959-2
Abstract: It is well known that neutrophil-mediated delivery of therapeutic agents is a promising method for treating tumors. However, owing to the limited number and limited uptake ability of neutrophils, determining a reasonable dose has become… read more here.
Keywords: mediated delivery; delivery; dir dadgc; neutrophil mediated ... See more keywords
Adenovirus-mediated delivery of Sema3A alleviates rheumatoid arthritis in a serum-transfer induced mouse model
Sign Up to like & getrecommendations! Published in 2017 at "Oncotarget"
DOI: 10.18632/oncotarget.19915
Abstract: Rheumatoid arthritis is a chronic autoimmune disease characterized by infiltration of inflammatory cells into the synovium and destruction of cartilage and bone. Macrophages, fibroblast-like synoviocytes (FLS), and osteoclasts are critical cells driving the pathogenesis of… read more here.
Keywords: mediated delivery; adenovirus mediated; sema3a; rheumatoid arthritis ... See more keywords
Engineered exosome-mediated delivery of functionally active miR-26a and its enhanced suppression effect in HepG2 cells [Erratum]
Sign Up to like & getrecommendations! Published in 2018 at "International Journal of Nanomedicine"
DOI: 10.2147/ijn.s178282
Abstract: [This corrects the article on p. 585 in vol. 13, PMID: 29430178.]. read more here.
Keywords: mediated delivery; active mir; delivery functionally; functionally active ... See more keywords
Recent Advances in Nanoparticle-Mediated Co-Delivery System: A Promising Strategy in Medical and Agricultural Field
Sign Up to like & getrecommendations! Published in 2023 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms24065121
Abstract: Drug and gene delivery systems mediated by nanoparticles have been widely studied for life science in the past decade. The application of nano-delivery systems can dramatically improve the stability and delivery efficiency of carried ingredients,… read more here.
Keywords: nanoparticle mediated; delivery; delivery system; field ... See more keywords