Oxone®-mediated direct arylselenylation of imidazo[2,1-b]thiazoles, imidazo[1,2-a]pyridines and 1H-pyrazoles
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DOI: 10.1016/j.tet.2018.06.046
Abstract: Abstract Oxone mediated reaction of imidazo[2,1-b]thiazole, imidazo[1,2-a]pyridine and 1H-pyrazole derivatives with diaryl diselenides is presented here. The methodology represents an efficient and simple protocol for carrying out the selective synthesis of 5-arylselanyl-imidazo[2,1-b]thiazoles, 3-arylselanyl-imidazo[1,2-a]pyridines and 4-arylselanyl-1H-pyrazoles… read more here.
Keywords: mediated direct; oxone mediated; imidazo; direct arylselenylation ... See more keywords
NDTP Mediated Direct Rapid Amide and Peptide Synthesis without Epimerization.
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DOI: 10.1021/acs.orglett.1c04258
Abstract: Herein, we explored an unprecedented mild, nonirritating, conveniently available, and recyclable coupling reagent NDTP, which could activate the carboxylic acids via acyl thiocyanide and enable the rapid amide and peptide synthesis at very mild conditions.… read more here.
Keywords: rapid amide; mediated direct; amide peptide; ndtp mediated ... See more keywords
Photoredox-Mediated Direct Cross-Dehydrogenative Coupling of Heteroarenes and Amines.
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DOI: 10.1021/acs.orglett.8b02389
Abstract: A photoredox-mediated direct cross-dehydrogenative coupling reaction to accomplish α-aminoalkylation of N-heteroarenes is reported. This mild reaction has a broad substrate scope, offers the first general method for synthesis of aminoalkylated N-heteroarenes without the need for… read more here.
Keywords: direct cross; mediated direct; cross dehydrogenative; photoredox mediated ... See more keywords
AAV-mediated direct in vivo CRISPR screen identifies functional suppressors in glioblastoma
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DOI: 10.1038/nn.4620
Abstract: A causative understanding of genetic factors that regulate glioblastoma pathogenesis is of central importance. Here we developed an adeno-associated virus–mediated, autochthonous genetic CRISPR screen in glioblastoma. Stereotaxic delivery of a virus library targeting genes commonly… read more here.
Keywords: mediated direct; crispr; direct vivo; aav mediated ... See more keywords
Silver-mediated, direct phosphorylation of BODIPY dyes at the 3- or 3,5-positions with H-phosphonates.
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DOI: 10.1039/d2cc00297c
Abstract: A direct and regioselective C-H/P-H cross-coupling of dialkyl phosphites, and diphenylphosphine oxide to easily available BODIPYs through an Ag-mediated radical addition, resulted in a series of new α-phosphorylated BODIPY fluorophores under mild conditions. Hydrolysis of… read more here.
Keywords: silver mediated; dyes positions; mediated direct; direct phosphorylation ... See more keywords
Cu(II)-mediated direct intramolecular cyclopropanation of distal olefinic acetate: access to cyclopropane-fused γ-lactone
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DOI: 10.1039/d3sc01752d
Abstract: Cyclopropane-fused ring scaffold represents one of the most appealing structural motifs in organic chemistry due to their wide presence in bioactive molecules and versatility in organic synthesis. These skeletons are... read more here.
Keywords: cyclopropane; mediated direct; cyclopropane fused; intramolecular cyclopropanation ... See more keywords