siRNA‐based nanotherapeutics as emerging modalities for immune‐mediated diseases: A preliminary review
Sign Up to like & getrecommendations! Published in 2022 at "Cell Biology International"
DOI: 10.1002/cbin.11841
Abstract: Immune‐mediated diseases (IMDs) are chronic conditions that have an immune‐mediated etiology. Clinically, these diseases appear to be unrelated, but pathogenic pathways have been shown to connect them. While inflammation is a common occurrence in the… read more here.
Keywords: mediated diseases; review; based sirna; immune mediated ... See more keywords
Development of JAK inhibitors for the treatment of immune-mediated diseases: kinase-targeted inhibitors and pseudokinase-targeted inhibitors.
Sign Up to like & getrecommendations! Published in 2020 at "Archives of pharmacal research"
DOI: 10.1007/s12272-020-01282-7
Abstract: JAKs are a family of intracellular tyrosine kinases consisting of four members, JAK1, JAK2, JAK3, and TYK2. They are key components of the JAK-STAT pathway that transmit signals of many cytokines involved in the pathogenesis… read more here.
Keywords: jak; mediated diseases; immune mediated; pseudokinase ... See more keywords
Coexistence of immune-mediated diseases in sarcoidosis Frequency and clinical significance in 1737 patients.
Sign Up to like & getrecommendations! Published in 2021 at "Joint bone spine"
DOI: 10.1016/j.jbspin.2021.105236
Abstract: OBJECTIVE To analyze whether immune-mediated diseases (IMDs) occurs in sarcoidosis more commonly than expected in the general population, and how concomitant IMDs influence the clinical presentation of the disease. METHODS We searched for coexisting IMDs… read more here.
Keywords: mediated diseases; general population; 1737 patients; sarcoidosis ... See more keywords
COLLAGENOUS COLITIS IS ASSOCIATED WITH HLA SIGNATURE AND SHARES GENETIC RISKS WITH OTHER IMMUNE-MEDIATED DISEASES.
Sign Up to like & getrecommendations! Published in 2020 at "Gastroenterology"
DOI: 10.1053/j.gastro.2020.04.063
Abstract: BACKGROUND AND AIMS Collagenous colitis (CC) is an inflammatory bowel disorder with unknown etiopatogenesis involving human leukocyte antigen (HLA)-related immune-mediated responses, environmental and genetic risk factors. We carried out an array-based genetic association study in… read more here.
Keywords: risk; mediated diseases; collagenous colitis; disease ... See more keywords
S. aureus and IgE-mediated diseases: pilot or copilot? A narrative review
Sign Up to like & getrecommendations! Published in 2022 at "Expert Review of Clinical Immunology"
DOI: 10.1080/1744666x.2022.2074402
Abstract: ABSTRACT Introduction S. aureus is a major opportunistic pathogen that has been implicated in the pathogenesis of several chronic inflammatory diseases including bronchial asthma, chronic rhinosinusitis with nasal polyps (CRSwNP), chronic spontaneous urticaria (CSU), and… read more here.
Keywords: mediated diseases; aureus ige; aureus enterotoxins; ige mediated ... See more keywords
A Common Variant in 11q23.3 Is Associated with Susceptibility to Atopic Dermatitis in the Han Chinese Population.
Sign Up to like & getrecommendations! Published in 2021 at "Genetic testing and molecular biomarkers"
DOI: 10.1089/gtmb.2020.0335
Abstract: Background: Genome-wide association studies (GWASs) have identified many genetic variants that are risk factors for numerous immune-mediated diseases. In particular, different immune-mediated diseases have been found to share the same susceptibility loci. Therefore, exploring the… read more here.
Keywords: mediated diseases; susceptibility; atopic dermatitis; chinese population ... See more keywords
Sleep dysregulation in sympathetic-mediated diseases: implications for disease progression.
Sign Up to like & getrecommendations! Published in 2022 at "Sleep"
DOI: 10.1093/sleep/zsac166
Abstract: The autonomic nervous system (ANS) play an important role in the coordination of several physiological functions including sleep/wake process. Significant changes in ANS activity occur during wake-to-sleep transition maintaining the adequate cardiorespiratory regulation and brain… read more here.
Keywords: mediated diseases; wake; progression; sympathetic mediated ... See more keywords
Clustering of immune-mediated diseases in sarcoidosis.
Sign Up to like & getrecommendations! Published in 2019 at "Current opinion in pulmonary medicine"
DOI: 10.1097/mcp.0000000000000598
Abstract: PURPOSE OF REVIEW Sarcoidosis is an immune-mediated disease of unknown cause. Immune-mediated diseases appear to cluster in patients and in families. We review what is known on this topic for sarcoidosis, and what factors may… read more here.
Keywords: mediated diseases; sarcoidosis; immune mediated; risk ... See more keywords
AB0212 NON-ADHERENCE IN RHEUMATOLOGIC IMMUNE-MEDIATED DISEASES
Sign Up to like & getrecommendations! Published in 2021 at "Annals of the Rheumatic Diseases"
DOI: 10.1136/annrheumdis-2021-eular.1304
Abstract: Patient adherence is a key determinant of treatment success in rheumatologic immune-mediated diseases. Available data about adherence to biological treatments and factors associated to non-adherence is limited in Spain. Moreover, no studies compare adherence between… read more here.
Keywords: mediated diseases; rheumatologic immune; dispensing visits; immune mediated ... See more keywords
AB0825 JAK2 (V617F) MUTATION AND ASSOCIATION TO IMMUNE MEDIATED DISEASES. STUDY OF 130 PATIENTS FROM A SINGLE UNIVERSITY HOSPITAL
Sign Up to like & getrecommendations! Published in 2021 at "Annals of the Rheumatic Diseases"
DOI: 10.1136/annrheumdis-2021-eular.2161
Abstract: Janus Kinases (JAK) are tirosin-kinases that can promote cytokine production in immune and hematopoietic cells. The JAK-2 (V617F) mutation is the most frequently detected mutation in myeloproliferative neoplasms (MPN) which include essential thrombocythemia (ET), polycythemia… read more here.
Keywords: mediated diseases; immune mediated; v617f mutation; mutation ... See more keywords
Genetics of Pediatric Immune-Mediated Diseases and Human Immunity.
Sign Up to like & getrecommendations! Published in 2021 at "Annual review of immunology"
DOI: 10.1146/annurev-immunol-093019-124513
Abstract: Primary immunodeficiency diseases (PIDs) are a rapidly growing, heterogeneous group of genetically determined diseases characterized by defects in the immune system. While individually rare, collectively PIDs affect between 1/1,000 and 1/5,000 people worldwide. The clinical… read more here.
Keywords: mediated diseases; genetics; pediatric immune; genetics pediatric ... See more keywords