Metal-Mediated DNA Nanotechnology in 3D: Structural Library by Templated Diffraction.
Sign Up to like & getrecommendations! Published in 2023 at "Advanced materials"
DOI: 10.1002/adma.202201938
Abstract: DNA double helices containing metal-mediated DNA (mmDNA) base pairs have been constructed from Ag+ and Hg2+ ions between pyrimidine:pyrimidine pairs with the promise of nanoelectronics. Rational design of mmDNA nanomaterials has been impractical without a… read more here.
Keywords: mediated dna; metal mediated; dna; nanotechnology ... See more keywords
Emamectin benzoate induces ROS-mediated DNA damage and apoptosis in Trichoplusia Tn5B1-4 cells.
Sign Up to like & getrecommendations! Published in 2017 at "Chemico-biological interactions"
DOI: 10.1016/j.cbi.2017.06.004
Abstract: Emamectin benzoate (EMB), a novel macrocyclic lactone insecticide, possesses high efficacy and beneficial selective toxicity in agriculture, but so far the EMB-induced cytotoxic action in arthropod insect remains unclear. The present studies were carried out… read more here.
Keywords: dna damage; ros mediated; apoptosis; mediated dna ... See more keywords
Efficient retroelement-mediated DNA writing in bacteria.
Sign Up to like & getrecommendations! Published in 2021 at "Cell systems"
DOI: 10.1016/j.cels.2021.07.001
Abstract: The ability to efficiently and dynamically change information stored in genomes would enable powerful strategies for studying cell biology and controlling cellular phenotypes. Current recombineering-mediated DNA writing platforms in bacteria are limited to specific laboratory… read more here.
Keywords: dna; retroelement mediated; dna writing; efficient retroelement ... See more keywords
Somatic Niche Cells Regulate the CEP-1/p53-Mediated DNA Damage Response in Primordial Germ Cells.
Sign Up to like & getrecommendations! Published in 2019 at "Developmental cell"
DOI: 10.1016/j.devcel.2019.06.012
Abstract: Genome integrity in primordial germ cells (PGCs) is a prerequisite for fertility and species maintenance. In C. elegans, PGCs require global-genome nucleotide excision repair (GG-NER) to remove UV-induced DNA lesions. Failure to remove the lesions leads… read more here.
Keywords: cep p53; dna damage; p53 mediated; mediated dna ... See more keywords
CuII-mediated DNA base pairing of a triazole-4-carboxylate nucleoside prepared by click chemistry.
Sign Up to like & getrecommendations! Published in 2023 at "Chemical communications"
DOI: 10.1039/d2cc06205d
Abstract: Artificial metal-mediated DNA base pairing is a promising strategy for creating highly functionalized DNA supramolecules. Here we report a novel ligand-type triazole-4-carboxylate (TazC) nucleoside that is readily prepared by the click reaction. TazC nucleosides were… read more here.
Keywords: mediated dna; base pairing; chemistry; triazole carboxylate ... See more keywords
Producing irreversible topoisomerase II-mediated DNA breaks by site-specific Pt(II)-methionine coordination chemistry
Sign Up to like & getrecommendations! Published in 2017 at "Nucleic Acids Research"
DOI: 10.1093/nar/gkx742
Abstract: Abstract Human type II topoisomerase (Top2) isoforms, hTop2α and hTop2β, are targeted by some of the most successful anticancer drugs. These drugs induce Top2-mediated DNA cleavage to trigger cell-death pathways. The potency of these drugs… read more here.
Keywords: chemistry; dna breaks; drug; topoisomerase ... See more keywords
5-Formylcytosine mediated DNA–protein cross-links block DNA replication and induce mutations in human cells
Sign Up to like & getrecommendations! Published in 2018 at "Nucleic Acids Research"
DOI: 10.1093/nar/gky809
Abstract: There was a typographical error on page 6458, column 1, line 12 and on page 6459, column 2, line 53. In both instances, dNTP concentrations should be listed as ‘5, 10, 25, 50, 100, 150,… read more here.
Keywords: cross links; links block; protein cross; dna protein ... See more keywords
Patchouli alcohol induces G0 /G1 cell cycle arrest and apoptosis in vincristine-resistant non-small cell lung cancer through ROS-mediated DNA damage.
Sign Up to like & getrecommendations! Published in 2023 at "Thoracic cancer"
DOI: 10.1111/1759-7714.14982
Abstract: BACKGROUND Lung cancer, especially non-small cell lung cancer (NSCLC), is one of the leading causes of cancer-related deaths worldwide. Vincristine (VCR) is a chemotherapeutic agent for lung cancers; however, its effectiveness is limited by side… read more here.
Keywords: mediated dna; lung cancer; dna damage; lung ... See more keywords
TBX20 inhibits colorectal cancer tumorigenesis by impairing NHEJ-mediated DNA repair.
Sign Up to like & getrecommendations! Published in 2022 at "Cancer science"
DOI: 10.1111/cas.15348
Abstract: DNA high methylation is one of driving force for colorectal carcinoma (CRC) pathogenesis. Transcription factors (TFs) can determine cell fate and play fundamental roles in multistep process of tumorigenesis. Dysregulation of DNA methylation of TFs… read more here.
Keywords: dna; dna repair; nhej mediated; crc ... See more keywords
Abstract 1218: Mercury(II)-induced abnormalities in processing of topoisomerase I-mediated DNA damage
Sign Up to like & getrecommendations! Published in 2023 at "Cancer Research"
DOI: 10.1158/1538-7445.am2023-1218
Abstract: Mercury (Hg) is a persistent environmental pollutant that has long been associated with neurotoxic and other noncancer health effects in exposed populations. Recent large epidemiological studies using different internal indices of Hg exposure have found… read more here.
Keywords: mediated dna; topoisomerase mediated; damage; dna damage ... See more keywords
UVB-mediated DNA damage induces matrix metalloproteinases to promote photoaging in an AhR- and SP1-dependent manner
Sign Up to like & getrecommendations! Published in 2022 at "JCI Insight"
DOI: 10.1172/jci.insight.156344
Abstract: It is currently thought that UVB radiation drives photoaging of the skin primarily by generating ROS. In this model, ROS purportedly activates activator protein-1 to upregulate MMPs 1, 3, and 9, which then degrade collagen… read more here.
Keywords: mediated dna; sp1; damage; dna damage ... See more keywords