Polymer-mediated drug supersaturation - A spotlight on the interplay between phase-separated amorphous drug colloids and dissolved molecules.
Sign Up to like & getrecommendations! Published in 2021 at "Journal of colloid and interface science"
DOI: 10.1016/j.jcis.2021.06.089
Abstract: HYPOTHESIS Colloidal aggregation phenomena have been found responsible for the supersaturation of poorly water-soluble drugs, potentially leading to bioavailability enhancements. Unlike coarse precipitates, phase separation in the form of colloids, is expected to enhance drug… read more here.
Keywords: drug supersaturation; phase; polymer mediated; mediated drug ... See more keywords
Heptamethine cyanine dye mediated drug delivery: Hype or Hope.
Sign Up to like & getrecommendations! Published in 2020 at "Bioconjugate chemistry"
DOI: 10.1021/acs.bioconjchem.0c00302
Abstract: This review covers the application of heptamethine cyanine dye (HMCD) mediated drug delivery. A relatively small number of HMCDs possess tumour targeting abilities, and this has spurred interest from research groups to explore them as… read more here.
Keywords: cyanine dye; drug delivery; mediated drug; heptamethine cyanine ... See more keywords
Aldehyde oxidase mediated drug metabolism: an underpredicted obstacle in drug discovery and development
Sign Up to like & getrecommendations! Published in 2022 at "Drug Metabolism Reviews"
DOI: 10.1080/03602532.2022.2144879
Abstract: Abstract Aldehyde oxidase (AO) has garnered curiosity as a non-CYP metabolizing enzyme in drug development due to unexpected consequences such as toxic metabolite generation and high metabolic clearance resulting in the clinical failure of new… read more here.
Keywords: clearance; metabolism; mediated drug; development ... See more keywords
Acoustic Characterization of a Vessel-on-a-Chip Microfluidic System for Ultrasound-Mediated Drug Delivery
Sign Up to like & getrecommendations! Published in 2018 at "IEEE Transactions on Ultrasonics, Ferroelectrics, and Frequency Control"
DOI: 10.1109/tuffc.2018.2803137
Abstract: Ultrasound in the presence of gas-filled microbubbles can be used to enhance local uptake of drugs and genes. To study the drug delivery potential and its underlying physical and biological mechanisms, an in vitro vessel… read more here.
Keywords: chip microfluidic; ultrasound mediated; drug delivery; mediated drug ... See more keywords
Quantitative prediction of P‐glycoprotein‐mediated drug–drug interactions and intestinal absorption using humanized mice
Sign Up to like & getrecommendations! Published in 2021 at "British Journal of Pharmacology"
DOI: 10.1111/bph.15612
Abstract: P‐glycoprotein (P‐gp) exhibits a broad substrate specificity and affects pharmacokinetics, especially intestinal absorption. However, prediction, in vivo, of P‐gp‐mediated drug–drug interaction (DDI) and non‐linear absorption at the preclinical stage, is challenging. Here we evaluate the… read more here.
Keywords: absorption; intestinal absorption; mediated drug; drug ... See more keywords
Physiologically‐based pharmacokinetic model‐based translation of OATP1B‐mediated drug–drug interactions from coproporphyrin I to probe drugs
Sign Up to like & getrecommendations! Published in 2022 at "Clinical and Translational Science"
DOI: 10.1111/cts.13272
Abstract: The accurate prediction of OATP1B‐mediated drug–drug interactions (DDIs) is challenging for drug development. Here, we report a physiologically‐based pharmacokinetic (PBPK) model analysis for clinical DDI data generated in heathy subjects who received oral doses of… read more here.
Keywords: mediated drug; oatp1b; oatp1b mediated; model ... See more keywords
Target‐mediated drug disposition modeling of an anti‐TFPI antibody (MG1113) in cynomolgus monkeys to predict human pharmacokinetics and pharmacodynamics
Sign Up to like & getrecommendations! Published in 2021 at "Journal of Thrombosis and Haemostasis"
DOI: 10.1111/jth.15244
Abstract: MG1113 is a human monoclonal antibody of tissue factor pathway inhibitor (TFPI) under development for prophylaxis for hemophilia patients with or without inhibitors against factor VIII products, which have been used for the treatment of… read more here.
Keywords: disposition modeling; antibody; mediated drug; tfpi ... See more keywords
Exosomal transmission between macrophages and cancer cells: new insights to stroma-mediated drug resistance
Sign Up to like & getrecommendations! Published in 2018 at "Oncotarget"
DOI: 10.18632/oncotarget.26463
Abstract: Although pancreatic ductal adenocarcinoma (PDA) ranks fourth among cancer-related deaths, the cure rate of the disease hardly changed during the last four decades. This dismal prognosis is attributed to two factors: i. Late detection, at… read more here.
Keywords: drug resistance; mediated drug; resistance; cancer cells ... See more keywords
Recent Advances in Macrophage-Mediated Drug Delivery Systems
Sign Up to like & getrecommendations! Published in 2021 at "International Journal of Nanomedicine"
DOI: 10.2147/ijn.s298159
Abstract: Abstract Macrophages have been extensively used in the development of drug delivery systems, as they can prolong the circulation and release of drugs, extend their half-life, increase their stability and targeting ability, and reduce immunogenicity.… read more here.
Keywords: macrophage mediated; drug; mediated drug; drug delivery ... See more keywords
Microneedle-mediated drug delivery for cutaneous diseases
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Bioengineering and Biotechnology"
DOI: 10.3389/fbioe.2022.1032041
Abstract: Microneedles have garnered significant interest as transdermal drug delivery route owing to the advantages of nonselective loading capacity, minimal invasiveness, simple operation, and good biocompatibility. A number of therapeutics can be loaded into microneedles, including… read more here.
Keywords: mediated drug; microneedle mediated; cutaneous diseases; drug delivery ... See more keywords
Human Mesenchymal Stem Cells as a Carrier for a Cell-Mediated Drug Delivery
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Bioengineering and Biotechnology"
DOI: 10.3389/fbioe.2022.796111
Abstract: A number of preclinical and clinical studies have demonstrated the efficiency of mesenchymal stromal cells to serve as an excellent base for a cell-mediated drug delivery system. Cell-based targeted drug delivery has received much attention… read more here.
Keywords: cell; mediated drug; drug delivery; drug ... See more keywords