Towards streamlined product information: reporting of transporter-mediated drug interactions
Sign Up to like & getrecommendations! Published in 2024 at "European Journal of Clinical Pharmacology"
DOI: 10.1007/s00228-024-03772-9
Abstract: The purpose of this study is to investigate the reporting of risks associated with transporter-mediated drug-drug interactions (DDIs) in medicinal product information and to identify suitable wording for future standardisation of summaries of product characteristics… read more here.
Keywords: information; product information; transporter mediated; mediated drug ... See more keywords
Polymer-mediated drug supersaturation - A spotlight on the interplay between phase-separated amorphous drug colloids and dissolved molecules.
Sign Up to like & getrecommendations! Published in 2021 at "Journal of colloid and interface science"
DOI: 10.1016/j.jcis.2021.06.089
Abstract: HYPOTHESIS Colloidal aggregation phenomena have been found responsible for the supersaturation of poorly water-soluble drugs, potentially leading to bioavailability enhancements. Unlike coarse precipitates, phase separation in the form of colloids, is expected to enhance drug… read more here.
Keywords: drug supersaturation; phase; polymer mediated; mediated drug ... See more keywords
Heptamethine cyanine dye mediated drug delivery: Hype or Hope.
Sign Up to like & getrecommendations! Published in 2020 at "Bioconjugate chemistry"
DOI: 10.1021/acs.bioconjchem.0c00302
Abstract: This review covers the application of heptamethine cyanine dye (HMCD) mediated drug delivery. A relatively small number of HMCDs possess tumour targeting abilities, and this has spurred interest from research groups to explore them as… read more here.
Keywords: cyanine dye; drug delivery; mediated drug; heptamethine cyanine ... See more keywords
Aldehyde oxidase mediated drug metabolism: an underpredicted obstacle in drug discovery and development
Sign Up to like & getrecommendations! Published in 2022 at "Drug Metabolism Reviews"
DOI: 10.1080/03602532.2022.2144879
Abstract: Abstract Aldehyde oxidase (AO) has garnered curiosity as a non-CYP metabolizing enzyme in drug development due to unexpected consequences such as toxic metabolite generation and high metabolic clearance resulting in the clinical failure of new… read more here.
Keywords: clearance; metabolism; mediated drug; development ... See more keywords
Non-IgE-mediated drug-induced hypersensitivity reactions in pediatrics
Sign Up to like & getrecommendations! Published in 2024 at "Current Opinion in Pediatrics"
DOI: 10.1097/mop.0000000000001395
Abstract: Purpose of review Despite their prevalence and potential severity, non-IgE-mediated drug-induced hypersensitivity reactions (DHRs) are under-researched and poorly defined, particularly in children. Presentations range from mild cutaneous reactions to severe systemic diseases, with pathophysiological mechanisms… read more here.
Keywords: non ige; ige mediated; mediated drug;
Acoustic Characterization of a Vessel-on-a-Chip Microfluidic System for Ultrasound-Mediated Drug Delivery
Sign Up to like & getrecommendations! Published in 2018 at "IEEE Transactions on Ultrasonics, Ferroelectrics, and Frequency Control"
DOI: 10.1109/tuffc.2018.2803137
Abstract: Ultrasound in the presence of gas-filled microbubbles can be used to enhance local uptake of drugs and genes. To study the drug delivery potential and its underlying physical and biological mechanisms, an in vitro vessel… read more here.
Keywords: chip microfluidic; ultrasound mediated; drug delivery; mediated drug ... See more keywords
Quantitative prediction of P‐glycoprotein‐mediated drug–drug interactions and intestinal absorption using humanized mice
Sign Up to like & getrecommendations! Published in 2021 at "British Journal of Pharmacology"
DOI: 10.1111/bph.15612
Abstract: P‐glycoprotein (P‐gp) exhibits a broad substrate specificity and affects pharmacokinetics, especially intestinal absorption. However, prediction, in vivo, of P‐gp‐mediated drug–drug interaction (DDI) and non‐linear absorption at the preclinical stage, is challenging. Here we evaluate the… read more here.
Keywords: absorption; intestinal absorption; mediated drug; drug ... See more keywords
Physiologically‐based pharmacokinetic model‐based translation of OATP1B‐mediated drug–drug interactions from coproporphyrin I to probe drugs
Sign Up to like & getrecommendations! Published in 2022 at "Clinical and Translational Science"
DOI: 10.1111/cts.13272
Abstract: The accurate prediction of OATP1B‐mediated drug–drug interactions (DDIs) is challenging for drug development. Here, we report a physiologically‐based pharmacokinetic (PBPK) model analysis for clinical DDI data generated in heathy subjects who received oral doses of… read more here.
Keywords: mediated drug; oatp1b; oatp1b mediated; model ... See more keywords
Predicting the Pharmacokinetics of T‐Cell Engagers as a Function of Target‐Mediated Drug Disposition
Sign Up to like & getrecommendations! Published in 2025 at "Clinical and Translational Science"
DOI: 10.1111/cts.70384
Abstract: T‐Cell Engagers (TCEs) are biological multi‐specific molecules designed to co‐engage targets on T cells and on a target cell for destruction. Molecular formats are typically derived from IgG monoclonal antibodies or similar fusion proteins with… read more here.
Keywords: mediated drug; cell engagers; drug disposition; target mediated ... See more keywords
Target‐mediated drug disposition modeling of an anti‐TFPI antibody (MG1113) in cynomolgus monkeys to predict human pharmacokinetics and pharmacodynamics
Sign Up to like & getrecommendations! Published in 2021 at "Journal of Thrombosis and Haemostasis"
DOI: 10.1111/jth.15244
Abstract: MG1113 is a human monoclonal antibody of tissue factor pathway inhibitor (TFPI) under development for prophylaxis for hemophilia patients with or without inhibitors against factor VIII products, which have been used for the treatment of… read more here.
Keywords: disposition modeling; antibody; mediated drug; tfpi ... See more keywords
Validity conditions of approximations for a target-mediated drug disposition model: A novel first-order approximation and its comparison to other approximations
Sign Up to like & getrecommendations! Published in 2024 at "PLOS Computational Biology"
DOI: 10.1371/journal.pcbi.1012066
Abstract: Target-mediated drug disposition (TMDD) is a phenomenon characterized by a drug’s high-affinity binding to a target molecule, which significantly influences its pharmacokinetic profile within an organism. The comprehensive TMDD model delineates this interaction, yet it… read more here.
Keywords: mediated drug; drug disposition; target mediated; drug ... See more keywords