Quantifying the contribution of Fc-mediated effector functions to the antiviral activity of anti–HIV-1 IgG1 antibodies in vivo
Sign Up to like & getrecommendations! Published in 2020 at "Proceedings of the National Academy of Sciences of the United States of America"
DOI: 10.1073/pnas.2008190117
Abstract: Significance Virus-neutralizing monoclonal antibodies have been tested for the treatment or prevention of HIV-1 infection. Such an antibody can block virus infectivity and mediate killing of virus-infected cells by Fc-mediated effector functions. The relative contributions… read more here.
Keywords: effector functions; antiviral activity; hiv; antibody ... See more keywords
Beyond Viral Neutralization.
Sign Up to like & getrecommendations! Published in 2017 at "AIDS research and human retroviruses"
DOI: 10.1089/aid.2016.0299
Abstract: It has been known for more than 30 years that HIV-1 infection drives a very potent B cell response resulting in the production of anti-HIV-1 antibodies targeting several viral proteins, particularly its envelope glycoproteins (Env).… read more here.
Keywords: antibody; effector function; mediated effector; neutralizing antibodies ... See more keywords
Estradiol-inducible AvrRps4 expression reveals distinct properties of TIR-NLR-mediated effector-triggered immunity
Sign Up to like & getrecommendations! Published in 2020 at "Journal of Experimental Botany"
DOI: 10.1093/jxb/erz571
Abstract: Inducible expression of AvrRps4 activates RRS1/RPS4-mediated effector-triggered immunity without the presence of pathogens, allowing us to characterize downstream immune responses triggered by TIR-NLRs without cell surface receptor-mediated immunity. read more here.
Keywords: effector triggered; triggered immunity; expression; mediated effector ... See more keywords
Enhancing the Anti-tumor Potency of a Novel Siglec-15 Antibody by Engineering its Fc-mediated Effector Functions
Sign Up to like & getrecommendations! Published in 2023 at "Journal of Immunotherapy (Hagerstown, Md. : 1997)"
DOI: 10.1097/cji.0000000000000465
Abstract: Siglec-15, an inhibitory immune checkpoint, is an emerging target in cancer immunotherapy. Blocking the function of Siglec-15 is an excellent strategy for cancer treatment and antibody blockade has been used to target Siglec-15. However, whether… read more here.
Keywords: enhancing anti; potency; mediated effector; effector functions ... See more keywords
HIV-1 Vpu restricts Fc-mediated effector functions in vivo
Sign Up to like & getrecommendations! Published in 2022 at "Cell reports"
DOI: 10.1101/2022.02.21.481308
Abstract: Non-neutralizing antibodies (nnAbs) can eliminate HIV-1-infected cells via antibody-dependent cellular cytotoxicity (ADCC) and were identified as a correlate of protection in the RV144 vaccine trial. Fc-mediated effector functions of nnAbs were recently shown to alter… read more here.
Keywords: hiv vpu; vpu restricts; mediated effector; vpu ... See more keywords