Quantifying the contribution of Fc-mediated effector functions to the antiviral activity of anti–HIV-1 IgG1 antibodies in vivo
Sign Up to like & getrecommendations! Published in 2020 at "Proceedings of the National Academy of Sciences of the United States of America"
DOI: 10.1073/pnas.2008190117
Abstract: Significance Virus-neutralizing monoclonal antibodies have been tested for the treatment or prevention of HIV-1 infection. Such an antibody can block virus infectivity and mediate killing of virus-infected cells by Fc-mediated effector functions. The relative contributions… read more here.
Keywords: effector functions; antiviral activity; hiv; antibody ... See more keywords
Maximizing activity and selectivity of antibody-mediated effector functions using antibody mixtures
Sign Up to like & getrecommendations! Published in 2025 at "mAbs"
DOI: 10.1080/19420862.2025.2480666
Abstract: ABSTRACT Fc-mediated effector functions are key for conferring potent antibody-mediated killing of cancer cells. However, it is difficult to achieve highly selective targeting of cancer cells while minimizing toxicity on healthy tissue because of the… read more here.
Keywords: antibody mediated; antibody; mediated effector; affinity ... See more keywords
Beyond Viral Neutralization.
Sign Up to like & getrecommendations! Published in 2017 at "AIDS research and human retroviruses"
DOI: 10.1089/aid.2016.0299
Abstract: It has been known for more than 30 years that HIV-1 infection drives a very potent B cell response resulting in the production of anti-HIV-1 antibodies targeting several viral proteins, particularly its envelope glycoproteins (Env).… read more here.
Keywords: antibody; effector function; mediated effector; neutralizing antibodies ... See more keywords
Estradiol-inducible AvrRps4 expression reveals distinct properties of TIR-NLR-mediated effector-triggered immunity
Sign Up to like & getrecommendations! Published in 2020 at "Journal of Experimental Botany"
DOI: 10.1093/jxb/erz571
Abstract: Inducible expression of AvrRps4 activates RRS1/RPS4-mediated effector-triggered immunity without the presence of pathogens, allowing us to characterize downstream immune responses triggered by TIR-NLRs without cell surface receptor-mediated immunity. read more here.
Keywords: effector triggered; triggered immunity; expression; mediated effector ... See more keywords
Enhancing the Anti-tumor Potency of a Novel Siglec-15 Antibody by Engineering its Fc-mediated Effector Functions
Sign Up to like & getrecommendations! Published in 2023 at "Journal of Immunotherapy (Hagerstown, Md. : 1997)"
DOI: 10.1097/cji.0000000000000465
Abstract: Siglec-15, an inhibitory immune checkpoint, is an emerging target in cancer immunotherapy. Blocking the function of Siglec-15 is an excellent strategy for cancer treatment and antibody blockade has been used to target Siglec-15. However, whether… read more here.
Keywords: enhancing anti; potency; mediated effector; effector functions ... See more keywords
HIV-1 Vpu restricts Fc-mediated effector functions in vivo
Sign Up to like & getrecommendations! Published in 2022 at "Cell reports"
DOI: 10.1101/2022.02.21.481308
Abstract: Non-neutralizing antibodies (nnAbs) can eliminate HIV-1-infected cells via antibody-dependent cellular cytotoxicity (ADCC) and were identified as a correlate of protection in the RV144 vaccine trial. Fc-mediated effector functions of nnAbs were recently shown to alter… read more here.
Keywords: hiv vpu; vpu restricts; mediated effector; vpu ... See more keywords
Enhancing Fc‐mediated effector functions of monoclonal antibodies: The example of HexaBodies
Sign Up to like & getrecommendations! Published in 2024 at "Immunological Reviews"
DOI: 10.1111/imr.13394
Abstract: Since the approval of the CD20‐targeting monoclonal antibody (mAb) rituximab for the treatment of lymphoma in 1997, mAb therapy has significantly transformed cancer treatment. With over 90 FDA‐approved mAbs for the treatment of various hematological… read more here.
Keywords: cancer; treatment; enhancing mediated; mediated effector ... See more keywords