Target-mediated exposure enhancement: a previously unexplored limit of TMDD
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DOI: 10.1007/s10928-020-09693-1
Abstract: Target-mediated drug disposition (TMDD) is often observed for targeted therapeutics, and manifests as decreases in clearance and volume of distribution with increasing dose as a result of saturable, high affinity target binding. In the present… read more here.
Keywords: previously unexplored; exposure enhancement; mediated exposure; target ... See more keywords