Construction of Novel Tetrahydro‐β‐carboline‐1‐thione Spirooxindoles by Brønsted Acid Mediated Formal [3+3] Cyclization of 3‐Indolylmethanols with 3‐Isothiocyanato Oxindoles
Sign Up to like & getrecommendations! Published in 2017 at "Journal of Heterocyclic Chemistry"
DOI: 10.1002/jhet.2708
Abstract: p-Toluenesulfonic acid mediated formal [3+3] cyclization of 3-indolylmethanols with 3-isothiocyanato oxindoles was realized. This transformation allowed for the synthesis of a series of novel tetrahydro-β-carboline-1-thione spirooxindoles in moderate to excellent yields (up to 99%) with… read more here.
Keywords: acid mediated; mediated formal; indolylmethanols isothiocyanato; cyclization indolylmethanols ... See more keywords
Synthesis of gem-Disulfonyl Enamines via an Iminyl-Radical-Mediated Formal 1,3-HAT/Radical Coupling Cascade.
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DOI: 10.1021/acs.orglett.2c02277
Abstract: We herein report the first example of an iminyl-radical-mediated formal 1,3-HAT/radical coupling cascade of vinyl azides leading to the synthesis of tetrasubstituted gem-disulfonyl enamines. It is possible to employ a variety of vinyl azides and… read more here.
Keywords: mediated formal; iminyl radical; hat radical; radical coupling ... See more keywords
gem-Difluoroallylation of Aryl Diazoesters via Catalyst-Free, Blue-Light-Mediated Formal Doyle-Kirmse Reaction.
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DOI: 10.1021/acs.orglett.9b00647
Abstract: A first example of low-energy blue-light-mediated formal Doyle-Kirmse reaction for gem-difluoroallylation of aryl diazoesters has been developed. A variety of highly functionalized gem-difluoroallyl containing esters bearing transformable sulfur and bromine groups were efficiently assembled with… read more here.
Keywords: blue light; formal doyle; mediated formal; light mediated ... See more keywords