Zn-Mediated Fragmentation of N-Alkoxyphthalimides Enabling the Synthesis of gem-Difluoroalkenes.
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DOI: 10.1021/acs.orglett.4c01433
Abstract: Zn-mediated generation of alkoxyl radicals from N-alkoxyphthalimides emerged as an efficient approach for forming diverse and valuable alkyl radicals through β-scission or a hydrogen atom transfer process. The alkyl radical species can be further trapped… read more here.
Keywords: gem difluoroalkenes; enabling synthesis; mediated fragmentation; alkoxyphthalimides enabling ... See more keywords
Zn-Mediated Fragmentation of Tertiary Alkyl Oxalates Enabling Formation of Alkylated and Arylated Quaternary Carbon Centers.
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DOI: 10.1021/jacs.8b12801
Abstract: Zn-mediated reduction of readily accessible dialkyl oxalates derived from tertiary alcohols provides an efficient approach to C-O bond fragmentation and alkyl radical formation. With MgCl2 as the indispensable additive and Ni as the promoter, trapping… read more here.
Keywords: alkylated arylated; carbon; formation; mediated fragmentation ... See more keywords