Polymer-mediated gene therapy: Recent advances and merging of delivery techniques.
Sign Up to like & getrecommendations! Published in 2019 at "Wiley interdisciplinary reviews. Nanomedicine and nanobiotechnology"
DOI: 10.1002/wnan.1598
Abstract: The ability to safely and precisely deliver genetic materials to target sites in complex biological environments is vital to the success of gene therapy. Numerous viral and nonviral vectors have been developed and evaluated for… read more here.
Keywords: polymer mediated; mediated gene; gene therapy; delivery techniques ... See more keywords
AAV-Mediated Gene Delivery to the Enteric Nervous System by Intracolonic Injection.
Sign Up to like & getrecommendations! Published in 2019 at "Methods in molecular biology"
DOI: 10.1007/978-1-4939-9139-6_24
Abstract: The enteric nervous system of the lower gastrointestinal tract comprises intrinsic neural circuits as well as extrinsic afferent and efferent innervation. The development of strategies for neuronal gene transfer has created new opportunities for functional… read more here.
Keywords: nervous system; mediated gene; enteric nervous; aav mediated ... See more keywords
Aminoclay as a highly effective cationic vehicle for enhancing adenovirus-mediated gene transfer through nanobiohybrid complex formation.
Sign Up to like & getrecommendations! Published in 2017 at "Acta biomaterialia"
DOI: 10.1016/j.actbio.2016.11.045
Abstract: Electrostatic complexation of adenovirus (Ad) with cationic lipids or polymers has been shown to be an effective means for overcoming the limitations of adenoviral vectors and enhancing gene-transfer efficacy. However, such complexation causes cytotoxicity, limiting… read more here.
Keywords: mediated gene; complexation; gene transfer; gene ... See more keywords
Repair of a Site-Specific DNA Cleavage: Old-School Lessons for Cas9-Mediated Gene Editing.
Sign Up to like & getrecommendations! Published in 2018 at "ACS chemical biology"
DOI: 10.1021/acschembio.7b00760
Abstract: CRISPR/Cas9-mediated gene editing may involve nonhomologous end-joining to create various insertion/deletions (indels) or may employ homologous recombination to modify precisely the target DNA sequence. Our understanding of these processes has been guided by earlier studies… read more here.
Keywords: gene editing; mediated gene; site specific; gene ... See more keywords
Comparison of effects of tobacco cigarettes, electronic nicotine delivery systems and tobacco heating products on miRNA-mediated gene expression. A systematic review
Sign Up to like & getrecommendations! Published in 2022 at "Toxicology Mechanisms and Methods"
DOI: 10.1080/15376516.2022.2089610
Abstract: Abstract Objectives This work attempts to summarize current knowledge on the effects of cigarettes, electronic nicotine delivery systems and tobacco heating products on miRNA-mediated gene expression regulation and on their possible impact on smoking-related respiratory… read more here.
Keywords: mirna mediated; expression; mediated gene; tobacco heating ... See more keywords
Applications of Virus Vector-Mediated Gene Therapy in China.
Sign Up to like & getrecommendations! Published in 2017 at "Human Gene Therapy"
DOI: 10.1089/hum.2017.238
Abstract: Due to the increased safety and efficiency of virus vectors, virus vector–mediated gene therapy is now widely used for various diseases, including monogenic diseases, complex disorders, and infectious diseases. Recent gene therapy trials have shown… read more here.
Keywords: mediated gene; gene therapy; virus vector; vector mediated ... See more keywords
Sensitized piRNA reporter identifies multiple RNA processing factors involved in piRNA-mediated gene silencing.
Sign Up to like & getrecommendations! Published in 2023 at "Genetics"
DOI: 10.1093/genetics/iyad095
Abstract: Metazoans guard their germlines against transposons and other foreign transcripts with PIWI-interacting RNAs (piRNAs). Due to the robust heritability of the silencing initiated by piRNAs in Caenorhabditis elegans (C. elegans), previous screens using C. elegans… read more here.
Keywords: reporter; gene silencing; rna processing; mediated gene ... See more keywords
Mechanistic Insights into MicroRNA-Mediated Gene Silencing.
Sign Up to like & getrecommendations! Published in 2019 at "Cold Spring Harbor perspectives in biology"
DOI: 10.1101/cshperspect.a032771
Abstract: MicroRNAs (miRNAs) posttranscriptionally regulate gene expression by repressing protein synthesis and exert a broad influence over development, physiology, adaptation, and disease. Over the past two decades, great strides have been made toward elucidating how miRNAs… read more here.
Keywords: mediated gene; gene silencing; gene; insights microrna ... See more keywords
From molecular basics to agronomic benefits: Insights into noncoding RNA-mediated gene regulation in plants.
Sign Up to like & getrecommendations! Published in 2022 at "Journal of integrative plant biology"
DOI: 10.1111/jipb.13420
Abstract: The development of plants is largely dependent on their growth environment. To better adapt to a particular habitat, plants have evolved various subtle regulatory mechanisms for altering gene expression. Noncoding RNAs (ncRNAs) constitute a major… read more here.
Keywords: gene regulation; mediated gene; gene; biology ... See more keywords
DNMT3B-Mediated Gene Body Methylation Suppresses Aberrant Transcription.
Sign Up to like & getrecommendations! Published in 2017 at "Cancer discovery"
DOI: 10.1158/2159-8290.cd-rw2017-043
Abstract: DNMT3B methylates intragenic DNA to prevent spurious transcription from cryptic intragenic sites. read more here.
Keywords: transcription; dnmt3b; gene body; mediated gene ... See more keywords
Transcutaneous ultrasound mediated gene delivery into canine livers achieves therapeutic levels of FVIII expression.
Sign Up to like & getrecommendations! Published in 2022 at "Blood advances"
DOI: 10.1182/bloodadvances.2021006016
Abstract: A safe, effective, and inclusive gene therapy will significantly benefit a large population of hemophilia patients. We employed a minimally invasive transcutaneous ultrasound mediated gene delivery (UMGD) strategy combined with microbubbles (MBs) to enhance gene… read more here.
Keywords: transcutaneous ultrasound; canine livers; mediated gene; gene ... See more keywords