Articles with "mediated hydrazinolysis" as a keyword



Traceless synthesis of protein thioesters using enzyme-mediated hydrazinolysis and subsequent self-editing of the cysteinyl prolyl sequence.

Sign Up to like & get
recommendations!
Published in 2019 at "Chemical communications"

DOI: 10.1039/c9cc03583d

Abstract: A traceless thioester-producing protocol featuring carboxypeptidase Y-mediated hydrazinolysis of cysteinyl prolyl leucine-tagged peptides has been developed. The hydrazinolysis followed by thioesterification affords cysteinyl prolyl thioesters. Self-editing of the tag and subsequent trans-thioesterification yields peptide thioesters.… read more here.

Keywords: self editing; traceless synthesis; hydrazinolysis; cysteinyl prolyl ... See more keywords