2,3,5,6-Tetramethylpyrazine protects retinal photoreceptors against endoplasmic reticulum stress by modulating ATF4-mediated inhibition of PRP aggregation.
Sign Up to like & getrecommendations! Published in 2021 at "Journal of molecular medicine"
DOI: 10.1007/s00109-020-02017-3
Abstract: Endoplasmic reticulum (ER) stress is a common threat to photoreceptors during the pathogenesis of chronic retinopathies and often results in irreversible visual impairment. 2,3,5,6-Tetramethylpyrazine (TMP), which possesses many beneficial pharmacological activities, is a potential drug… read more here.
Keywords: prp aggregation; atf4 mediated; stress; mediated inhibition ... See more keywords
Chronic antidepressant potentiates spontaneous activity of dorsal raphe serotonergic neurons by decreasing GABAB receptor-mediated inhibition of L-type calcium channels
Sign Up to like & getrecommendations! Published in 2017 at "Scientific Reports"
DOI: 10.1038/s41598-017-13599-3
Abstract: Spontaneous activity of serotonergic neurons of the dorsal raphe nucleus (DRN) regulates mood and motivational state. Potentiation of serotonergic function is one of the therapeutic strategies for treatment of various psychiatric disorders, such as major… read more here.
Keywords: gabab receptor; serotonergic neurons; spontaneous activity; mediated inhibition ... See more keywords
c-Myb-mediated inhibition of miR-601 in facilitating malignance of osteosarcoma via augmentation of PKMYT1
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DOI: 10.1038/s41598-022-10684-0
Abstract: The crosstalk between osteosarcoma (OS) development and abnormally expressed microRNA (miR)-601 is not explored explicitly. Here, we identified the downregulated miR-601 in osteosarcoma (OS) through a comprehensive bioinformatics analysis of GEO Datasets. The results indicated… read more here.
Keywords: pkmyt1; mir 601; osteosarcoma; mir ... See more keywords
Propulsive colonic contractions are mediated by inhibition-driven poststimulus responses that originate in interstitial cells of Cajal.
Sign Up to like & getrecommendations! Published in 2022 at "Proceedings of the National Academy of Sciences of the United States of America"
DOI: 10.1073/pnas.2123020119
Abstract: SignificanceThe peristaltic reflex elicits colonic migrating motor complexes (CMMCs) that are thought to be generated by enteric excitatory neurons stimulating smooth muscle cells (SMCs). We found that atropine did not block CMMCs and present a… read more here.
Keywords: colonic contractions; interstitial cells; contractions mediated; propulsive colonic ... See more keywords
In Vitro Anti-Inflammatory Activity of Ilex cornuta Extract Mediated by Inhibition of Extracellular Signal-Regulated Kinase Phosphorylation.
Sign Up to like & getrecommendations! Published in 2017 at "Journal of medicinal food"
DOI: 10.1089/jmf.2016.3913
Abstract: Ilex cornuta, commonly known as Chinese holly, is an evergreen shrub from the family Aquifoliaceae, and it is widely distributed in Korea and China. In folk medicine, the leaves of I. cornuta are used for… read more here.
Keywords: anti inflammatory; ilex cornuta; extracellular signal; mediated inhibition ... See more keywords
Haploinsufficiency of Tsc2 Leads to Hyperexcitability of Medial Prefrontal Cortex via Weakening of Tonic GABAB Receptor-mediated Inhibition.
Sign Up to like & getrecommendations! Published in 2020 at "Cerebral cortex"
DOI: 10.1093/cercor/bhaa187
Abstract: Loss-of-function mutation in one of the tumor suppressor genes TSC1 or TSC2 is associated with several neurological and psychiatric diseases, including autism spectrum disorders (ASDs). As an imbalance between excitatory and inhibitory neurotransmission, E/I ratio… read more here.
Keywords: inhibition; medial prefrontal; tsc2; mediated inhibition ... See more keywords
K-Cl Cotransporter 2–mediated Cl− Extrusion Determines Developmental Stage–dependent Impact of Propofol Anesthesia on Dendritic Spines
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DOI: 10.1097/aln.0000000000001587
Abstract: Background: General anesthetics potentiating &ggr;-aminobutyric acid (GABA)–mediated signaling are known to induce a persistent decrement in excitatory synapse number in the cerebral cortex when applied during early postnatal development, while an opposite action is produced… read more here.
Keywords: propofol; cotransporter mediated; mediated inhibition; gabaa mediated ... See more keywords
Curcumin, Piperine, and Capsaicin: A Comparative Study of Spice-Mediated Inhibition of Human Cytochrome P450 Isozyme Activities
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DOI: 10.1124/dmd.116.073213
Abstract: Inhibition of cytochrome P450 (P450) enzymes (CYP) has been shown to lower the metabolism of drugs that are P450 substrates and to consequently alter their pharmacokinetic profiles. Curcumin (CUR), piperine (PIP), and capsaicin (CAP) are… read more here.
Keywords: pip; p450; mediated inhibition; cytochrome p450 ... See more keywords
Osthole-Mediated Inhibition of Neurotoxicity Induced by Ropivacaine via Amplification of the Cyclic Adenosine Monophosphate Signaling Pathway
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DOI: 10.1177/15593258221088092
Abstract: Background Ropivacaine is widely used for clinical anesthesia and postoperative analgesia. However, the neurotoxicity induced by ropivacaine in a concentration- and duration-dependent manner, and it is difficult to prevent neurotoxicity. Osthole inhibits phosphodiesterase-4 activity by… read more here.
Keywords: induced ropivacaine; signaling pathway; mediated inhibition; neurotoxicity ... See more keywords
UVR8-mediated inhibition of shade avoidance involves HFR1 stabilization in Arabidopsis
Sign Up to like & getrecommendations! Published in 2020 at "PLoS Genetics"
DOI: 10.1371/journal.pgen.1008797
Abstract: Sun-loving plants perceive the proximity of potential light-competing neighboring plants as a reduction in the red:far-red ratio (R:FR), which elicits a suite of responses called the "shade avoidance syndrome" (SAS). Changes in R:FR are primarily… read more here.
Keywords: bhlh transcription; shade avoidance; mediated inhibition; shade ... See more keywords
Leptin attenuates D2 receptor‐mediated inhibition of putative ventral tegmental area dopaminergic neurons
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DOI: 10.14814/phy2.13631
Abstract: Obesity causes hyperleptinemia. We have previously shown that D2 receptor‐mediated inhibition of ventral tegmental area (VTA) dopaminergic neurons is attenuated in diet‐induced mice with obesity. Consequently, we hypothesized that high concentrations of serum leptin during… read more here.
Keywords: leptin; vta dopaminergic; mediated inhibition; dopaminergic neurons ... See more keywords