Unraveled role of TLR7-mediated interferon signaling activation in COVID-19
Sign Up to like & getrecommendations! Published in 2025 at "Frontiers in Cellular and Infection Microbiology"
DOI: 10.3389/fcimb.2025.1658249
Abstract: Emerging evidence underscores the critical role of Toll-like receptor 7 (TLR7)-mediated interferon (IFN) signaling in host defense against viral infections including SARS-CoV-2, through the modulation of both innate and adaptive immunity. However, the specific mechanisms… read more here.
Keywords: mediated interferon; covid; role; activation ... See more keywords
Grouper cGAS is a negative regulator of STING-mediated interferon response
Sign Up to like & getrecommendations! Published in 2023 at "Frontiers in Immunology"
DOI: 10.3389/fimmu.2023.1092824
Abstract: Cyclic GMP-AMP synthase (cGAS) is one of the classical pattern recognition receptors that recognizes mainly intracytoplasmic DNA. cGAS induces type I IFN responses to the cGAS-STING signaling pathway. To investigate the roles of cGAS-STING signaling… read more here.
Keywords: grouper cgas; interferon response; eccgas; negative regulator ... See more keywords