Roles for H+/K+‐ATPase and zinc transporter 3 in cAMP‐mediated lysosomal acidification in bafilomycin A1‐treated astrocytes
Sign Up to like & getrecommendations! Published in 2020 at "Glia"
DOI: 10.1002/glia.23952
Abstract: Vacuolar ATPase (v‐ATPase) is the main proton pump that acidifies vesicles such as lysosomes. Disruption in the lysosomal localization of v‐ATPase leads to lysosomal dysfunction, thus contributing to the pathogenesis of lysosomal storage disorders and… read more here.
Keywords: camp; atpase; mediated lysosomal; camp mediated ... See more keywords
Benzotriazole alleviates copper mediated lysosomal membrane damage and antioxidant defense system responses in earthworms (Eisenia fetida).
Sign Up to like & getrecommendations! Published in 2020 at "Ecotoxicology and environmental safety"
DOI: 10.1016/j.ecoenv.2020.110618
Abstract: Benzotriazole (BTR) is a common corrosion inhibitor used to protect copper (Cu) and Cu alloys. To reveal the combined subacute toxicity of BTR and Cu at environmental levels on terrestrial animals, the activity of antioxidative… read more here.
Keywords: antioxidant; mediated lysosomal; earthworms eisenia; antioxidant defense ... See more keywords
ACOD1-mediated lysosomal membrane permeabilization contributes to Mycobacterium tuberculosis–induced macrophage death
Sign Up to like & getrecommendations! Published in 2025 at "Proceedings of the National Academy of Sciences of the United States of America"
DOI: 10.1073/pnas.2425309122
Abstract: Significance Here, we show that when Mtb induces macrophages to express interferon-β (IFN-β), they overexpress an enzyme called ACOD1 normally found in mitochondria, whose product, itaconate, protects the cells. Surprisingly, that protective effect is overwhelmed… read more here.
Keywords: membrane permeabilization; lysosomal membrane; permeabilization contributes; mediated lysosomal ... See more keywords
AKT2-mediated lysosomal dysfunction promotes secretory autophagy in retinal pigment epithelium (RPE) cells
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DOI: 10.1080/15548627.2024.2413305
Abstract: ABSTRACT Age-related macular degeneration (AMD) is the leading cause of blindness in the elderly, with the non-neovascular or atrophic form being the most common. Current treatment options are limited, emphasizing the urgent need for new… read more here.
Keywords: rpe cells; secretory autophagy; autophagy; akt2 mediated ... See more keywords
New mechanism of metformin action mediated by lysosomal presenilin enhancer 2
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Diabetes Investigation"
DOI: 10.1111/jdi.13925
Abstract: Formation of the PEN2‐ATP6AP1 complex induced by the binding of metformin to PEN2 results in the inhibition of v‐ATPase activity and in the recruitment of AXIN/LKB1 to lysosomes, which in turn results in the phosphorylation… read more here.
Keywords: mechanism metformin; action mediated; mediated lysosomal; new mechanism ... See more keywords
TFEB-mediated lysosomal exocytosis alleviates high-fat diet–induced lipotoxicity in the kidney
Sign Up to like & getrecommendations! Published in 2023 at "JCI Insight"
DOI: 10.1172/jci.insight.162498
Abstract: Obesity is a major risk factor for end-stage kidney disease. We previously found that lysosomal dysfunction and impaired autophagic flux contribute to lipotoxicity in obesity-related kidney disease, in both humans and experimental animal models. However,… read more here.
Keywords: tfeb; lysosomal exocytosis; mediated lysosomal; kidney ... See more keywords