METTL3‐Mediated m6A mRNA Methylation Modulates Tooth Root Formation by Affecting NFIC Translation
Sign Up to like & getrecommendations! Published in 2020 at "Journal of Bone and Mineral Research"
DOI: 10.1002/jbmr.4180
Abstract: N6‐methyladenosine (m6A), as a eukaryotic mRNA modification catalyzed by methyltransferase METTL3, is involved in various processes of development or diseases via regulating RNA metabolism. However, the effect of METTL3‐mediated m6A modification in tooth development has… read more here.
Keywords: mettl3 mediated; mediated m6a; mettl3; root formation ... See more keywords
METTL3-mediated m6A methylation negatively modulates autophagy to support porcine blastocyst development‡
Sign Up to like & getrecommendations! Published in 2021 at "Biology of Reproduction"
DOI: 10.1093/biolre/ioab022
Abstract: Abstract N6-methyladenosine (m6A) catalyzed by METTL3 regulates the maternal-to-zygotic transition in zebrafish and mice. However, the role and mechanism of METTL3-mediated m6A methylation in blastocyst development remains unclear. Here, we show that METTL3-mediated m6A methylation… read more here.
Keywords: mettl3 mediated; mediated m6a; blastocyst development; blastocyst ... See more keywords
WTAP-Mediated m6A RNA Methylation Regulates the Differentiation of Bone Marrow Mesenchymal Stem Cells via the miR-29b-3p/HDAC4 Axis
Sign Up to like & getrecommendations! Published in 2023 at "Stem Cells Translational Medicine"
DOI: 10.1093/stcltm/szad020
Abstract: Abstract N6-methyladenosine (m6A) methylation, a well-known modification with new epigenetic functions, has been reported to participate in the progression of osteoporosis (OP), providing novel insights into the pathogenesis of OP. However, as the key component… read more here.
Keywords: mir 29b; wtap; methylation; wtap mediated ... See more keywords
New insights into the central sympathetic hyperactivity post‐myocardial infarction: Roles of METTL3‐mediated m6A methylation
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Cellular and Molecular Medicine"
DOI: 10.1111/jcmm.17183
Abstract: Ventricular arrhythmias (VAs) triggers by sympathetic nerve hyperactivity contribute to sudden cardiac death in myocardial infarction (MI) patients. Microglia‐mediated inflammation in the paraventricular nucleus (PVN) is involved in sympathetic hyperactivity after MI. N6‐methyladenosine (m6A), the… read more here.
Keywords: mettl3 mediated; mediated m6a; myocardial infarction; hyperactivity ... See more keywords
METTL3-Mediated m6A Modification of lncRNA MALAT1 Facilitates Prostate Cancer Growth by Activation of PI3K/AKT Signaling
Sign Up to like & getrecommendations! Published in 2022 at "Cell Transplantation"
DOI: 10.1177/09636897221122997
Abstract: Accumulating data show that N6-methyladenosine (m6A) methyltransferase METTL3 and long noncoding RNA MALAT1 act pivotal roles in multiple malignancies including prostate cancer (PCa). However, the role and molecular mechanism underlying METTL3-mediated m6A modification of MALAT1… read more here.
Keywords: pi3k akt; m6a modification; mettl3 mediated; mediated m6a ... See more keywords
RNA methylation pattern and immune microenvironment characteristics mediated by m6A regulator in ischemic stroke
Sign Up to like & getrecommendations! Published in 2023 at "Frontiers in Genetics"
DOI: 10.3389/fgene.2023.1148510
Abstract: Background: Ischemic stroke (IS) is a highly heterogeneous disease. Recent studies have shown that epigenetic variables affect the immune response. However, only a few studies have examined the relationship between IS and m6A immunoregulation. Therefore,… read more here.
Keywords: modification; immune microenvironment; mediated m6a; m6a ... See more keywords