CYP1A1 and 1B1‐mediated metabolic pathways of dolutegravir, an HIV integrase inhibitor
Sign Up to like & getrecommendations! Published in 2018 at "Biochemical Pharmacology"
DOI: 10.1016/j.bcp.2018.10.012
Abstract: &NA; Dolutegravir (DTG), a potent integrase inhibitor, is part of a recommended initial regimen for the treatment of human immunodeficiency virus (HIV). Prior reports demonstrated that the clearance of DTG was higher in current smokers… read more here.
Keywords: cyp1a1 1b1; metabolic pathways; dtg; mediated metabolic ... See more keywords
JMJD1C-mediated metabolic dysregulation contributes to HOXA9-dependent leukemogenesis
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DOI: 10.1038/s41375-018-0354-z
Abstract: Abnormal metabolism is a fundamental hallmark of cancer and represents a therapeutic opportunity, yet its regulation by oncogenes remains poorly understood. Here, we uncover that JMJD1C, a jumonji C (JmjC)-containing H3K9 demethylase, is a critical… read more here.
Keywords: dysregulation contributes; metabolic dysregulation; mediated metabolic; jmjd1c ... See more keywords
Human cytomegalovirus induces neuronal enolase to support virally mediated metabolic remodeling
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DOI: 10.1073/pnas.2205789119
Abstract: Viruses depend on cellular metabolic resources to supply the energy and biomolecular building blocks necessary for their replication. Human Cytomegalovirus (HCMV), a leading cause of birth defects and morbidity in immunosuppressed individuals, induces numerous metabolic… read more here.
Keywords: mediated metabolic; infection; hcmv; induces neuronal ... See more keywords
Mitochondrial ROS-Mediated Metabolic and Cytotoxic Effects of Isoproterenol on Cardiomyocytes Are p53-Dependent and Reversed by Curcumin
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DOI: 10.3390/molecules27041346
Abstract: Acute β-adrenergic stimulation contributes to heart failure. Here, we investigated the role of p53 in isoproterenol (ISO)-mediated metabolic and oxidative stress effects on cardiomyocytes and explored the direct protective effects offered by the antioxidant nutraceutical… read more here.
Keywords: mediated metabolic; mitochondrial ros; survival; curcumin ... See more keywords