Identification and human exposure prediction of two aldehyde oxidase-mediated metabolites of a methylquinoline-containing drug candidate
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DOI: 10.1080/00498254.2018.1444815
Abstract: Abstract 1. Aldehyde oxidase (AO enzymes)-mediated oxidation predominantly occurs at a carbon atom adjacent to the nitrogen on aromatic azaheterocycles. In the current report, we identified that AO enzymes oxidation took place at both the… read more here.
Keywords: mediated metabolites; exposure; human exposure; drug ... See more keywords