Radiosensitivity enhancement by Co‐NMS‐mediated mitochondrial impairment in glioblastoma
Sign Up to like & getrecommendations! Published in 2020 at "Journal of Cellular Physiology"
DOI: 10.1002/jcp.29774
Abstract: We investigated the radiosensitizing effects of Co‐NMS, a derivative of nimesulide based on a cobalt carbonyl complex, on malignant glioma cells. In the zebrafish exposed to Co‐NMS ranging from 5 to 20 μM, cell death and… read more here.
Keywords: radiosensitivity enhancement; mediated mitochondrial; impairment; nms mediated ... See more keywords
The role of SIRT3-mediated mitochondrial homeostasis in osteoarthritis
Sign Up to like & getrecommendations! Published in 2020 at "Cellular and Molecular Life Sciences"
DOI: 10.1007/s00018-020-03497-9
Abstract: Osteoarthritis is the most common degenerative joint disease and causes major pain and disability in adults. It has been reported that mitochondrial dysfunction in chondrocytes is associated with osteoarthritis. Sirtuins are a family of nicotinamide… read more here.
Keywords: homeostasis; mediated mitochondrial; osteoarthritis; mitochondrial homeostasis ... See more keywords
Carnosic acid induces apoptosis of hepatocellular carcinoma cells via ROS-mediated mitochondrial pathway.
Sign Up to like & getrecommendations! Published in 2017 at "Chemico-biological interactions"
DOI: 10.1016/j.cbi.2017.09.005
Abstract: Carnosic acid (CA), an important bioactive phenolic diterpene mainly found in labiate plants, exerts various biological functions, including antioxidant, anti-inflammatory, antitumor, and neuroprotective activities. In the present study, we proved the deleterious effects of CA… read more here.
Keywords: hepatocellular carcinoma; hcc; mediated mitochondrial; ros ... See more keywords
Lysionotin Induces Apoptosis of Hepatocellular Carcinoma Cells via Caspase-3 Mediated Mitochondrial Pathway.
Sign Up to like & getrecommendations! Published in 2021 at "Chemico-biological interactions"
DOI: 10.1016/j.cbi.2021.109500
Abstract: As the sixth most prevalent cancer, liver cancer has been reported as the second cause of cancer-induced deaths globally. Lysionotin, a flavonoid compound widely distributed in Lysionotus pauciflorus Maxim, has attracted considerable attention due to… read more here.
Keywords: caspase; mediated mitochondrial; caspase mediated; apoptosis ... See more keywords
Drp1-mediated mitochondrial fission contributes to mitophagy in paraquat-induced neuronal cell damage.
Sign Up to like & getrecommendations! Published in 2020 at "Environmental pollution"
DOI: 10.1016/j.envpol.2020.116413
Abstract: Paraquat (PQ) is one of the most widely used herbicides in the world due to its excellent weed control effects. Accumulating evidence has revealed that long-term exposure to PQ can significantly increase the risk of… read more here.
Keywords: paraquat; mediated mitochondrial; excessive mitophagy; mitochondrial fission ... See more keywords
Targeting IFN-γ-inducible lysosomal thiol reductase overcomes chemoresistance in AML through regulating the ROS-mediated mitochondrial damage
Sign Up to like & getrecommendations! Published in 2021 at "Translational Oncology"
DOI: 10.1016/j.tranon.2021.101159
Abstract: Highlights • GILT is upregulated in chemoresistant LSC-enriched CD34+ progenitor cells.• Inhibition of GILT in AML cells sensitized them to Ara-C treatment through ROS-mediated mitochondrial damage and apoptosis.• PI3K/Akt/NRF2 pathway inhibition is critical for the… read more here.
Keywords: mitochondrial damage; mediated mitochondrial; ros mediated; targeting ifn ... See more keywords
Selective Cytotoxicity of Luteolin and Kaempferol on Cancerous Hepatocytes Obtained from Rat Model of Hepatocellular Carcinoma: Involvement of ROS-Mediated Mitochondrial Targeting
Sign Up to like & getrecommendations! Published in 2018 at "Nutrition and Cancer"
DOI: 10.1080/01635581.2018.1460679
Abstract: ABSTRACT To evaluate the cytotoxicity effects of luteolin (LUT) and kaempferol (KAE) via reactive oxygen species (ROS) mediated mitochondrial targeting on hepatocytes obtained from the liver of hepatocellular carcinoma (HCC) rats. In this study, HCC… read more here.
Keywords: lut kae; mediated mitochondrial; ros mediated; hepatocytes obtained ... See more keywords
Protective Effect of Electroacupuncture on the Barrier Function of Intestinal Injury in Endotoxemia through HO-1/PINK1 Pathway-Mediated Mitochondrial Dynamics Regulation
Sign Up to like & getrecommendations! Published in 2023 at "Oxidative Medicine and Cellular Longevity"
DOI: 10.1155/2023/1464853
Abstract: Background and Aims Endotoxemia (ET) is a common critical illness in patients receiving intensive care and is associated with high mortality and prolonged hospital stay. The intestinal epithelial cell dysfunction is regarded as the “engine”… read more here.
Keywords: pathway mediated; injury; pink1 pathway; pink1 ... See more keywords
AMPK Activation Alleviates Myocardial Ischemia-Reperfusion Injury by Regulating Drp1-Mediated Mitochondrial Dynamics
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Pharmacology"
DOI: 10.3389/fphar.2022.862204
Abstract: Mitochondrial dysfunction is a salient feature of myocardial ischemia/reperfusion injury (MIRI), while the potential mechanism of mitochondrial dynamics disorder remains unclear. This study sought to explore whether activation of Adenosine monophosphate-activated protein kinase (AMPK) could… read more here.
Keywords: drp1; drp1 mediated; mitochondrial dynamics; ischemia reperfusion ... See more keywords
Extracellular Vesicle-Mediated Mitochondrial Reprogramming in Cancer
Sign Up to like & getrecommendations! Published in 2022 at "Cancers"
DOI: 10.3390/cancers14081865
Abstract: Simple Summary Mitochondria are important organelles involved in several key cellular processes including energy production and cell death regulation. For this reason, it is unsurprising that mitochondrial function and structure are altered in several pathological… read more here.
Keywords: cancer; extracellular vesicle; vesicle mediated; mitochondrial reprogramming ... See more keywords
Berberine Protects Glomerular Podocytes via Inhibiting Drp1-Mediated Mitochondrial Fission and Dysfunction
Sign Up to like & getrecommendations! Published in 2019 at "Theranostics"
DOI: 10.7150/thno.30640
Abstract: Elevated levels of plasma free fatty acid (FFA) and disturbed mitochondrial dynamics play crucial roles in the pathogenesis of diabetic kidney disease (DKD). However, the mechanisms by which FFA leads to mitochondrial damage in glomerular… read more here.
Keywords: mediated mitochondrial; dysfunction; drp1 mediated; podocytes via ... See more keywords