A brief overview of BNIP3L/NIX receptor-mediated mitophagy.
Sign Up to like & getrecommendations! Published in 2021 at "FEBS open bio"
DOI: 10.1002/2211-5463.13307
Abstract: Mitophagy is a form of autophagy specialized to selectively remove mitochondria. Although the PINK1/Parkin pathway is the best described mitophagy of damaged mitochondria, receptor/mediated mitophagy seems to have a pivotal role in cellular development and… read more here.
Keywords: mediated mitophagy; bnip3l nix; brief overview; receptor ... See more keywords
Involvement of Parkin‐mediated mitophagy in the pathogenesis of chronic obstructive pulmonary disease‐related sarcopenia
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Cachexia, Sarcopenia and Muscle"
DOI: 10.1002/jcsm.12988
Abstract: Sarcopenia is characterized by the loss of skeletal muscle mass and strength and is associated with poor prognosis in patients with chronic obstructive pulmonary disease (COPD). Cigarette smoke (CS) exposure, a major cause for COPD,… read more here.
Keywords: obstructive pulmonary; chronic obstructive; related sarcopenia; pulmonary disease ... See more keywords
Induction of PINK1/Parkin-Mediated Mitophagy.
Sign Up to like & getrecommendations! Published in 2018 at "Methods in molecular biology"
DOI: 10.1007/7651_2017_7
Abstract: PINK1/Parkin mitophagy is a key mechanism to contribute mitochondrial quality control, and the defects are thought to be a cause of those Parkinson's disease onsets. Upon loss of mitochondrial membrane potential, PINK1 and Parkin are… read more here.
Keywords: mediated mitophagy; pink1; pink1 parkin; parkin mediated ... See more keywords
PINK1/Parkin-mediated mitophagy is activated to protect against AFB1-induced kidney damage in mice.
Sign Up to like & getrecommendations! Published in 2022 at "Chemico-biological interactions"
DOI: 10.1016/j.cbi.2022.109884
Abstract: Aflatoxin B1 (AFB1) is a toxic food pollutant that has extensive deleterious impacts on the kidney. Oxidative stress represents the primary mechanism of AFB1 nephrotoxicity and can also cause mitochondrial damage. Damaged mitochondria can trigger… read more here.
Keywords: damage; kidney damage; mediated mitophagy; parkin mediated ... See more keywords
FUN14 domain-containing 1-mediated mitophagy suppresses interleukin-1β production in macrophages.
Sign Up to like & getrecommendations! Published in 2020 at "International immunopharmacology"
DOI: 10.1016/j.intimp.2020.106964
Abstract: Mitochondria play a critical role in triggering immune response. Although recent evidence indicates that autophagy/mitophagy can suppress inflammation via regulation of mitochondrial homeostasis, limited information is available regarding physiological regulation of mitochondria-controlled inflammation. In this… read more here.
Keywords: mediated mitophagy; domain containing; production; fun14 domain ... See more keywords
Activation of PINK1/Parkin-mediated mitophagy protects against apoptosis in kidney damage caused by aluminum.
Sign Up to like & getrecommendations! Published in 2022 at "Journal of inorganic biochemistry"
DOI: 10.1016/j.jinorgbio.2022.111765
Abstract: Aluminum (Al) induces apoptosis via oxidative stress and/or mitochondrial damage. Kidney is the main organ of Al excretion, but whether Al causes apoptosis in kidney of mice remains unclear. Mitophagy maintains cell homeostasis via clearing… read more here.
Keywords: damage; kidney damage; parkin; mediated mitophagy ... See more keywords
Ubiquitination and receptor-mediated mitophagy converge to eliminate oxidation-damaged mitochondria during hypoxia
Sign Up to like & getrecommendations! Published in 2021 at "Redox Biology"
DOI: 10.1016/j.redox.2021.102047
Abstract: The contribution of the Ubiquitin-Proteasome System (UPS) to mitophagy has been largely attributed to the E3 ubiquitin ligase Parkin. Here we show that in response to the oxidative stress associated with hypoxia or the hypoxia… read more here.
Keywords: oxidation damaged; damaged mitochondria; mediated mitophagy; receptor mediated ... See more keywords
Salidroside Inhibits α-Amanitin-Induced AML-12 Cell Apoptosis via the Regulation of PINK1/Parkin-Mediated Mitophagy and Mitochondrial Function.
Sign Up to like & getrecommendations! Published in 2024 at "Chemical research in toxicology"
DOI: 10.1021/acs.chemrestox.4c00139
Abstract: Poisoning caused by the mushroom Amanita phalloides, due to the toxin α-amanitin, accounts for approximately 90% of food poisoning deaths in China with no specific antidotes. To investigate the role of salidroside (Sal) in α-amanitin… read more here.
Keywords: sal; parkin mediated; mediated mitophagy; cell apoptosis ... See more keywords
ACSL1 improves pulmonary fibrosis by reducing mitochondrial damage and activating PINK1/Parkin mediated mitophagy
Sign Up to like & getrecommendations! Published in 2024 at "Scientific Reports"
DOI: 10.1038/s41598-024-78136-5
Abstract: Pulmonary fibrosis is a chronic interstitial lung disease with no curative therapeutic treatment, leading to significant mortality. The aims of this study were to investigate the regulatory mechanisms of mitophagy in the progression of pulmonary… read more here.
Keywords: parkin mediated; mediated mitophagy; fibrosis; damage ... See more keywords
Fasting activates optineurin-mediated mitophagy in chondrocytes to protect against osteoarthritis
Sign Up to like & getrecommendations! Published in 2025 at "Communications Biology"
DOI: 10.1038/s42003-025-07541-x
Abstract: Mitochondrial homeostasis plays a crucial role in the pathogenesis of osteoarthritis (OA), a chronic musculoskeletal disorder characterized by articular cartilage degeneration and chondrocyte apoptosis. However, molecular mechanisms underlying the association between mitophagy and OA remain… read more here.
Keywords: mediated mitophagy; role; optn mediated; progression ... See more keywords
FNDC-1-Mediated Mitophagy and ATFS-1 Coordinate to Protect Against Hypoxia-Reoxygenation.
Sign Up to like & getrecommendations! Published in 2021 at "Autophagy"
DOI: 10.1080/15548627.2021.1872885
Abstract: Mitochondrial quality control (MQC) balances organelle adaptation and elimination, and mechanistic crosstalk between the underlying molecular processes affects subsequent stress outcomes. FUNDC1 (FUN14 domain containing 1) is a mammalian mitophagy receptor that responds to hypoxia-reoxygenation… read more here.
Keywords: fndc; hypoxia reoxygenation; mediated mitophagy; mitophagy atfs ... See more keywords