Therapeutic Management of Immune-Mediated Necrotizing Myositis
Sign Up to like & getrecommendations! Published in 2021 at "Current Treatment Options in Rheumatology"
DOI: 10.1007/s40674-021-00174-1
Abstract: The idiopathic inflammatory myopathies are a heterogeneous group of autoimmune disorders characterized by skeletal muscle inflammation leading to chronic muscle weakness. Immune-mediated necrotizing myopathy (IMNM) is a distinct subgroup of inflammatory myopathy typically characterized by… read more here.
Keywords: autoantibody; imnm; treatment; mediated necrotizing ... See more keywords
Immune-mediated necrotizing myopathy: clinical features and pathogenesis
Sign Up to like & getrecommendations! Published in 2020 at "Nature Reviews Rheumatology"
DOI: 10.1038/s41584-020-00515-9
Abstract: Immune-mediated necrotizing myopathy (IMNM) is a group of inflammatory myopathies that was distinguished from polymyositis in 2004. Most IMNMs are associated with anti-signal recognition particle (anti-SRP) or anti-3-hydroxy-3-methylglutaryl-coA reductase (anti-HMGCR) myositis-specific autoantibodies, although ~20% of… read more here.
Keywords: muscle; imnm; mediated necrotizing; immune mediated ... See more keywords
Cancer and immune-mediated necrotizing myopathy: A longitudinal referral case-controlled outcomes evaluation.
Sign Up to like & getrecommendations! Published in 2022 at "Rheumatology"
DOI: 10.1093/rheumatology/keac144
Abstract: OBJECTIVES To investigate immune-mediated necrotizing myopathy (IMNM) association with cancer and its clinical implications. METHODS IMNM cases were identified January 1st, 2000 to December 31st, 2020 matching sex and age controls (4:1). RESULTS 152 patients… read more here.
Keywords: cancer; imnm diagnosis; fdg pet; immune mediated ... See more keywords
Interleukin-6 trans-signaling regulates monocyte chemoattractant protein-1 production in immune-mediated necrotizing myopathy.
Sign Up to like & getrecommendations! Published in 2024 at "Rheumatology"
DOI: 10.1093/rheumatology/keae118
Abstract: OBJECTIVE Immune-mediated necrotizing myopathy (IMNM) is pathologically characterized by diffuse myofiber necrosis and regeneration, myophagocytosis, and a sparse inflammatory infiltrate. The monocyte chemoattractant protein-1 (MCP-1) is a key chemokine that regulates monocyte/macrophage infiltration into injured… read more here.
Keywords: mediated necrotizing; mcp expression; immune mediated; monocyte chemoattractant ... See more keywords
Increased prevalence and incidence of statin-associated immune-mediated necrotizing myopathy in Native Americans.
Sign Up to like & getrecommendations! Published in 2025 at "Rheumatology"
DOI: 10.1093/rheumatology/keaf618
Abstract: OBJECTIVES Statin-associated immune-mediated necrotizing myopathy (IMNM) is an idiopathic inflammatory myopathy (IIM) associated with anti-3-hydroxy-3-methylglutaryl coenzyme A reductase (anti-HMGCR) antibodies. This research determined the characteristics and outcomes of Native Americans vs non-Native Americans (non-NA) diagnosed… read more here.
Keywords: mediated necrotizing; associated immune; immune mediated; native americans ... See more keywords
Peculiar clinicopathological features of immune-mediated necrotizing myopathies.
Sign Up to like & getrecommendations! Published in 2018 at "Current Opinion in Rheumatology"
DOI: 10.1097/bor.0000000000000547
Abstract: PURPOSE OF REVIEW In the past decade, immune-mediated necrotizing myopathies have emerged as a separate entity in the heterogenous group of autoimmune myopathies. This group is characterized by clinical manifestations restricted to the muscle tissue,… read more here.
Keywords: necrotizing myopathies; muscle; imnm; mediated necrotizing ... See more keywords
Anti-NXP2-antibody-positive immune-mediated necrotizing myopathy associated with acute myeloid leukemia
Sign Up to like & getrecommendations! Published in 2018 at "Medicine"
DOI: 10.1097/md.0000000000011501
Abstract: Rationale: Idiopathic inflammatory myopathies have been extensively reported associated with malignancy. Immune-mediated necrotizing myopathy (IMNM), however, has rarely been connected with malignancy including acute myeloid leukemia (AML). Patient concerns: A 65-year-old woman was diagnosed with… read more here.
Keywords: necrotizing myopathy; mediated necrotizing; myeloid leukemia; anti nxp2 ... See more keywords
Association of immune‐mediated necrotizing myopathy with HLA polymorphisms
Sign Up to like & getrecommendations! Published in 2022 at "HLA"
DOI: 10.1111/tan.14950
Abstract: Immune‐mediated necrotizing myopathy (IMNM) is a type of autoimmune myositis typically characterized clinically by proximal muscle weakness with elevated creatine kinase levels, pathologically by myofiber necrosis and regeneration with paucity of lymphocytic cell infiltration, and… read more here.
Keywords: necrotizing myopathy; hla; immune mediated; mediated necrotizing ... See more keywords
Leflunomide-Induced Immune-Mediated Necrotizing Myopathy in a Patient With Rheumatoid Arthritis: A Case Report
Sign Up to like & getrecommendations! Published in 2023 at "Journal of Investigative Medicine High Impact Case Reports"
DOI: 10.1177/23247096221150636
Abstract: Immune-mediated necrotizing myopathy (IMNM) is a subtype of inflammatory myopathy that is characterized by proximal muscle weakness, markedly elevated serum creatine kinase, myopathic electromyographic findings, and muscle biopsies revealing necrosis or regeneration with sparse inflammatory… read more here.
Keywords: necrotizing myopathy; leflunomide; immune mediated; mediated necrotizing ... See more keywords
Characteristics of cardiac involvement in immune-mediated necrotizing myopathy
Sign Up to like & getrecommendations! Published in 2023 at "Frontiers in Immunology"
DOI: 10.3389/fimmu.2023.1094611
Abstract: Objective To investigate the characteristics of cardiac involvement due to Immune-mediated Necrotizing Myopathy (IMNM). Methods Patients diagnosed with Immune-mediated Necrotizing Myopathy (IMNM) who attended the Department of Neurology and the Department of Rheumatology and Immunology… read more here.
Keywords: necrotizing myopathy; immune mediated; involvement; mediated necrotizing ... See more keywords
Case report: Rapid clinical improvement of anti-HMGCR immune-mediated necrotizing myopathy treated with efgartigimod
Sign Up to like & getrecommendations! Published in 2024 at "Frontiers in Immunology"
DOI: 10.3389/fimmu.2024.1495415
Abstract: Immune-mediated necrotizing myopathy (IMNM) with anti-HMGCR antibody positivity is characterized by proximal extremity weakness, increased creatine kinase, and extensive muscle edema. There is an urgent need to find more appropriate treatment options for anti-HMGCR IMNM… read more here.
Keywords: mediated necrotizing; immune mediated; anti; necrotizing myopathy ... See more keywords