Therapeutic Management of Immune-Mediated Necrotizing Myositis
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DOI: 10.1007/s40674-021-00174-1
Abstract: The idiopathic inflammatory myopathies are a heterogeneous group of autoimmune disorders characterized by skeletal muscle inflammation leading to chronic muscle weakness. Immune-mediated necrotizing myopathy (IMNM) is a distinct subgroup of inflammatory myopathy typically characterized by… read more here.
Keywords: autoantibody; imnm; treatment; mediated necrotizing ... See more keywords
Immune-mediated necrotizing myopathy: clinical features and pathogenesis
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DOI: 10.1038/s41584-020-00515-9
Abstract: Immune-mediated necrotizing myopathy (IMNM) is a group of inflammatory myopathies that was distinguished from polymyositis in 2004. Most IMNMs are associated with anti-signal recognition particle (anti-SRP) or anti-3-hydroxy-3-methylglutaryl-coA reductase (anti-HMGCR) myositis-specific autoantibodies, although ~20% of… read more here.
Keywords: muscle; imnm; mediated necrotizing; immune mediated ... See more keywords
Cancer and immune-mediated necrotizing myopathy: A longitudinal referral case-controlled outcomes evaluation.
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DOI: 10.1093/rheumatology/keac144
Abstract: OBJECTIVES To investigate immune-mediated necrotizing myopathy (IMNM) association with cancer and its clinical implications. METHODS IMNM cases were identified January 1st, 2000 to December 31st, 2020 matching sex and age controls (4:1). RESULTS 152 patients… read more here.
Keywords: cancer; imnm diagnosis; fdg pet; immune mediated ... See more keywords
Peculiar clinicopathological features of immune-mediated necrotizing myopathies.
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DOI: 10.1097/bor.0000000000000547
Abstract: PURPOSE OF REVIEW In the past decade, immune-mediated necrotizing myopathies have emerged as a separate entity in the heterogenous group of autoimmune myopathies. This group is characterized by clinical manifestations restricted to the muscle tissue,… read more here.
Keywords: necrotizing myopathies; muscle; imnm; mediated necrotizing ... See more keywords
Anti-NXP2-antibody-positive immune-mediated necrotizing myopathy associated with acute myeloid leukemia
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DOI: 10.1097/md.0000000000011501
Abstract: Rationale: Idiopathic inflammatory myopathies have been extensively reported associated with malignancy. Immune-mediated necrotizing myopathy (IMNM), however, has rarely been connected with malignancy including acute myeloid leukemia (AML). Patient concerns: A 65-year-old woman was diagnosed with… read more here.
Keywords: necrotizing myopathy; mediated necrotizing; myeloid leukemia; anti nxp2 ... See more keywords
Association of immune‐mediated necrotizing myopathy with HLA polymorphisms
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DOI: 10.1111/tan.14950
Abstract: Immune‐mediated necrotizing myopathy (IMNM) is a type of autoimmune myositis typically characterized clinically by proximal muscle weakness with elevated creatine kinase levels, pathologically by myofiber necrosis and regeneration with paucity of lymphocytic cell infiltration, and… read more here.
Keywords: necrotizing myopathy; hla; immune mediated; mediated necrotizing ... See more keywords
Leflunomide-Induced Immune-Mediated Necrotizing Myopathy in a Patient With Rheumatoid Arthritis: A Case Report
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DOI: 10.1177/23247096221150636
Abstract: Immune-mediated necrotizing myopathy (IMNM) is a subtype of inflammatory myopathy that is characterized by proximal muscle weakness, markedly elevated serum creatine kinase, myopathic electromyographic findings, and muscle biopsies revealing necrosis or regeneration with sparse inflammatory… read more here.
Keywords: necrotizing myopathy; leflunomide; immune mediated; mediated necrotizing ... See more keywords
Characteristics of cardiac involvement in immune-mediated necrotizing myopathy
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DOI: 10.3389/fimmu.2023.1094611
Abstract: Objective To investigate the characteristics of cardiac involvement due to Immune-mediated Necrotizing Myopathy (IMNM). Methods Patients diagnosed with Immune-mediated Necrotizing Myopathy (IMNM) who attended the Department of Neurology and the Department of Rheumatology and Immunology… read more here.
Keywords: necrotizing myopathy; immune mediated; involvement; mediated necrotizing ... See more keywords
Pediatric immune-mediated necrotizing myopathy
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DOI: 10.3389/fneur.2023.1123380
Abstract: Immune-mediated necrotizing myopathy (IMNM) is a type of inflammatory myopathy. Most patients with IMNM produce anti-3-hydroxy-3-methylglutaryl coenzyme A reductase or anti-signal-recognition particle autoantibodies. IMNM is much rarer in children than in adults. We conducted this… read more here.
Keywords: pediatric imnm; immune mediated; necrotizing myopathy; mediated necrotizing ... See more keywords
Pathophysiological Mechanisms and Treatment of Dermatomyositis and Immune Mediated Necrotizing Myopathies: A Focused Review
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DOI: 10.3390/ijms23084301
Abstract: Idiopathic inflammatory myopathies (IIM), collectively known as myositis, are a composite group of rare autoimmune diseases affecting mostly skeletal muscle, although other organs or tissues may also be involved. The main clinical feature of myositis… read more here.
Keywords: myositis; immune mediated; mediated necrotizing; pathophysiological mechanisms ... See more keywords
Immune-Mediated Necrotizing Myopathy and Dietary Sources of Statins
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DOI: 10.7326/l17-0620
Abstract: Background: Skeletal muscle diseases caused by autoimmune disorders are classified as idiopathic inflammatory myopathies. Muscle biopsy is used to divide these diseases into polymyositis, dermatomyositis, inclusion body myositis, nonspecific myositis, and immune-mediated necrotizing myopathy. Some… read more here.
Keywords: necrotizing myopathy; mediated necrotizing; statin; immune mediated ... See more keywords