The inhibition of LSD1 via sequestration contributes to tau-mediated neurodegeneration
Sign Up to like & getrecommendations! Published in 2020 at "Proceedings of the National Academy of Sciences of the United States of America"
DOI: 10.1073/pnas.2013552117
Abstract: Significance We have made the discovery that pathological tau functions through the histone demethylase LSD1 in the Alzheimer’s disease pathway. Thus, we have identified a mechanism that links tau to the downstream neuronal dysfunction pathways.… read more here.
Keywords: tau mediated; tau; neurodegeneration; pathological tau ... See more keywords
Genetic analysis of KillerRed in C. elegans identifies a shared role of calcium genes in ROS-mediated neurodegeneration
Sign Up to like & getrecommendations! Published in 2019 at "Journal of Neurogenetics"
DOI: 10.1080/01677063.2018.1531857
Abstract: Abstract In C. elegans, neurodegeneration induced by excitotoxicity or aggregation of misfolded proteins is dependent on genes involved in calcium release from the endoplasmic reticulum. Reactive oxygen species (ROS) can also induce neurodegeneration, but the… read more here.
Keywords: ros mediated; neurodegeneration; calcium; mediated neurodegeneration ... See more keywords
IgLON5-mediated neurodegeneration is a differential diagnosis of CNS Whipple disease
Sign Up to like & getrecommendations! Published in 2018 at "Neurology"
DOI: 10.1212/wnl.0000000000005679
Abstract: A 49-year-old man developed cold intolerance as an isolated symptom 2 years prior to presentation. At age 48, he developed jerks in the trunk and lower limbs during the day and tapping movements in the… read more here.
Keywords: cns whipple; iglon5 mediated; differential diagnosis; neurodegeneration differential ... See more keywords
Author response: IgLON5-mediated neurodegeneration is a differential diagnosis of CNS Whipple disease
Sign Up to like & getrecommendations! Published in 2019 at "Neurology"
DOI: 10.1212/wnl.0000000000007088
Abstract: We thank Drs. Bally and Lang for their interest in our report,1 and for alerting clinicians to the fact that palatal tremor (PT) occurs in only a minority of patients with neurologic Whipple disease (WhD).… read more here.
Keywords: whipple disease; iglon5 mediated; whd; mediated neurodegeneration ... See more keywords
RhoGAPp190: A potential player in tbph-mediated neurodegeneration in Drosophila
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DOI: 10.1371/journal.pone.0195845
Abstract: TDP-43 is an ubiquitous and highly conserved ribonucleoprotein involved in several cellular processes including pre-mRNA splicing, transcription, mRNA stability and transport. Notwithstanding the evidence of TDP-43 involvement in the pathogenesis of different neurodegenerative disorders (i.e.… read more here.
Keywords: tbph mediated; rhogapp190 potential; rhogapp190; mediated neurodegeneration ... See more keywords