Transactivation Domain of Human c-Myc Is Essential to Alleviate Poly(Q)-Mediated Neurotoxicity in Drosophila Disease Models
Sign Up to like & getrecommendations! Published in 2017 at "Journal of Molecular Neuroscience"
DOI: 10.1007/s12031-017-0910-4
Abstract: Polyglutamine (poly(Q)) disorders, such as Huntington’s disease (HD) and spinocerebellar ataxias, represent a group of neurological disorders which arise due to an atypically expanded poly(Q) tract in the coding region of the affected gene. Pathogenesis… read more here.
Keywords: poly; poly mediated; transactivation domain; mediated neurotoxicity ... See more keywords
Valproic acid protects against MPP+-mediated neurotoxicity in SH-SY5Y Cells through autophagy
Sign Up to like & getrecommendations! Published in 2017 at "Neuroscience Letters"
DOI: 10.1016/j.neulet.2016.12.017
Abstract: Autophagy is a common physiological activity in cells. Studies show that dysregulation of autophagy is involved in the pathogenesis of Parkinson's disease (PD). As a commonly used anti-epileptic drug, valproic acid (VPA) has shown neuroprotective… read more here.
Keywords: protects mpp; vpa; acid protects; mpp mediated ... See more keywords
Acrolein-mediated neurotoxicity in growing Wistar male rats.
Sign Up to like & getrecommendations! Published in 2018 at "Pesticide biochemistry and physiology"
DOI: 10.1016/j.pestbp.2018.05.006
Abstract: Abstract Acrolein is an environmental and food contaminant widely produced by thermal processed organic compounds. It can be used as a biocide and is known to be generated endogenously by lipid peroxidation. This study was… read more here.
Keywords: male rats; neurotoxicity growing; acrolein mediated; wistar male ... See more keywords
In vivo neutralization of dendrotoxin-mediated neurotoxicity of black mamba venom by oligoclonal human IgG antibodies
Sign Up to like & getrecommendations! Published in 2018 at "Nature Communications"
DOI: 10.1038/s41467-018-06086-4
Abstract: The black mamba (Dendroaspis polylepis) is one of the most feared snake species of the African savanna. It has a potent, fast-acting neurotoxic venom comprised of dendrotoxins and α-neurotoxins associated with high fatality in untreated… read more here.
Keywords: oligoclonal human; igg; dendrotoxin mediated; mediated neurotoxicity ... See more keywords
Nivolumab-induced immune-mediated neurotoxicity in Hodgkin lymphoma
Sign Up to like & getrecommendations! Published in 2020 at "Baylor University Medical Center Proceedings"
DOI: 10.1080/08998280.2019.1668719
Abstract: Abstract Nivolumab, a monoclonal antibody against programmed cell death-1 used to treat multiple cancers, has fewer side effects than traditional chemotherapy but has displayed a propensity to cause a host of immune-related adverse events. We… read more here.
Keywords: hodgkin lymphoma; induced immune; nivolumab induced; immune mediated ... See more keywords
Inhibition of Perforin-Mediated Neurotoxicity Attenuates Neurological Deficits After Ischemic Stroke
Sign Up to like & getrecommendations! Published in 2021 at "Frontiers in Cellular Neuroscience"
DOI: 10.3389/fncel.2021.664312
Abstract: Perforin-mediated cytotoxicity plays a crucial role in microbial defense, tumor surveillance, and primary autoimmune disorders. However, the contribution of the cytolytic protein perforin to ischemia-induced secondary tissue damage in the brain has not been fully… read more here.
Keywords: ischemic stroke; perforin mediated; perforin cd45; perforin ... See more keywords