Integrated in silico and in vivo approaches to investigate effects of BDE-99 mediated by the nuclear receptors on developing zebrafish.
Sign Up to like & getrecommendations! Published in 2018 at "Environmental toxicology and chemistry"
DOI: 10.1002/etc.4000
Abstract: One of the most abundant polybrominated diphenyl ethers (PBDEs) is 2,2',4,4',5-pentabromodiphenyl ether (BDE-99), which persists and potentially bioaccumulates in aquatic wildlife. Previous studies in mammals have shown that BDE-99 affects development and disrupts certain endocrine… read more here.
Keywords: nuclear receptors; silico vivo; receptor; mediated nuclear ... See more keywords
Durable response with single-agent acalabrutinib in patients with relapsed or refractory mantle cell lymphoma
Sign Up to like & getrecommendations! Published in 2019 at "Leukemia"
DOI: 10.1038/s41375-019-0575-9
Abstract: Winkelmann N, Aranaz P, et al. Mutations in SETBP1 are recurrent in myelodysplastic syndromes and often coexist with cytogenetic markers associated with disease progression. Br J Haematol. 2013;163:235–9. 9. Nguyen N, Vishwakarma BA, Oakley K,… read more here.
Keywords: export; durable response; nuclear export; crm1 ... See more keywords
Ibetazol, a novel inhibitor of importin β1-mediated nuclear import
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DOI: 10.1038/s42003-024-07237-8
Abstract: Nucleocytoplasmatic transport plays an essential role in eukaryotic cell homeostasis and is mediated by karyopherins. Importin β1 (KPNB1) and its adaptor protein importin α1 (KPNA2) are the best-characterized karyopherins that effect nuclear import. Here, we… read more here.
Keywords: nuclear import; importin mediated; inhibitor importin; importin ... See more keywords
A mitochondria-to-nucleus regulation mediated by the nuclear-translocated mitochondrial lncRNAs
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DOI: 10.1371/journal.pgen.1011580
Abstract: A bidirectional nucleus-mitochondria communication is essential for homeostasis and stress. By acting as critical molecules, the nuclear-encoded lncRNAs (nulncRNAs) have been implicated in the nucleus-to-mitochondria anterograde regulation. However, role of mitochondrial-derived lncRNAs (mtlncRNAs) in the… read more here.
Keywords: nuclear translocated; regulation mediated; mitochondria nucleus; nucleus regulation ... See more keywords