Pathway analysis of genetic variants in folate‐mediated one‐carbon metabolism‐related genes and survival in a prospectively followed cohort of colorectal cancer patients
Sign Up to like & getrecommendations! Published in 2018 at "Cancer Medicine"
DOI: 10.1002/cam4.1407
Abstract: Folate‐mediated one‐carbon metabolism (FOCM) is a key pathway essential for nucleotide synthesis, DNA methylation, and repair. This pathway is a critical target for 5‐fluorouracil (5‐FU), which is predominantly used for colorectal cancer (CRC) treatment. A… read more here.
Keywords: folate mediated; mediated one; metabolism; related genes ... See more keywords
Montmorillonite-KSF mediated one step synthesis of pyranochromene derivatives
Sign Up to like & getrecommendations! Published in 2018 at "Journal of Molecular Structure"
DOI: 10.1016/j.molstruc.2018.06.052
Abstract: Abstract One-pot three-component reaction of substituted aromatic aldehydes, 2-cyanoacetamide and 4-hydroxycoumarin in the presence of Montmorillonite-KSF (MKSF) in ethanol results in the formation of pyrano[3,2-c]chromene-3-carboxylates (5a-m) has been described. The reaction was tested in different… read more here.
Keywords: mediated one; ksf mediated; one step; reaction ... See more keywords
TPGS-mediated one-pot synthesis, XRD structural analysis, antimicrobial evaluation and molecular docking of novel heterocycles as potential inhibitors of p53-MDM2 protein
Sign Up to like & getrecommendations! Published in 2020 at "Journal of Molecular Structure"
DOI: 10.1016/j.molstruc.2019.127252
Abstract: Abstract Novel heterocyclic bioactive small molecules bearing thioether moiety, fluorine containing dihydro pyridine and dihydro pyran were synthesized and characterized using spectroscopic methods (FT-IR, 1H, 13C and 19F NMR), LC-MS and SC-XRD. The reaction conducted… read more here.
Keywords: tpgs mediated; mediated one; one pot; p53 mdm2 ... See more keywords
A Smartphone-Mediated "All-In-One" Biosensing Chip for Visual and Value-Assisted Detection.
Sign Up to like & getrecommendations! Published in 2024 at "Analytical chemistry"
DOI: 10.1021/acs.analchem.4c03854
Abstract: A smartphone-mediated self-powered biosensor is fabricated for miRNA-141 detection based on the CRISPR/Cas12a cross-cutting technique and a highly efficient nanozyme. As a novel nanozyme and a signal-amplified coreaction accelerator, the AuPtPd@GDY nanozyme exhibits an excellent… read more here.
Keywords: detection; value assisted; mirna 141; mediated one ... See more keywords
I2-Mediated One-Pot Three-Component Tandem Cyclization: Synthesis of 1H-Pyrrolo[3,4-c]quinoline-1,3(2H)-diones and Their Photophysical Property Studies.
Sign Up to like & getrecommendations! Published in 2025 at "Organic letters"
DOI: 10.1021/acs.orglett.5c02425
Abstract: An I2-mediated one-pot three-component tandem cyclization for the synthesis of 1H-pyrrolo[3,4-c]quinoline-1,3(2H)-diones (PQLs) has been reported. Starting from aromatic amines and maleimides, when aromatic aldehydes or di-tert-butyl peroxide (DTBP) were present, different substitution types of PQLs… read more here.
Keywords: pot three; component tandem; one pot; three component ... See more keywords
CRISPR-Cas9 mediated one-step disabling of pancreatogenesis in pigs
Sign Up to like & getrecommendations! Published in 2017 at "Scientific Reports"
DOI: 10.1038/s41598-017-08596-5
Abstract: Genome editing using programmable nucleases has revolutionized biomedical research. CRISPR-Cas9 mediated zygote genome editing enables high efficient production of knockout animals suitable for studying development and relevant human diseases. Here we report efficient disabling pancreatogenesis… read more here.
Keywords: mediated one; crispr cas9; disabling pancreatogenesis; cas9 mediated ... See more keywords
SO2F2-Mediated one-pot cascade process for transformation of aldehydes (RCHO) to cyanamides (RNHCN)
Sign Up to like & getrecommendations! Published in 2020 at "RSC Advances"
DOI: 10.1039/d0ra02631j
Abstract: A simple, mild and practical cascade process for the direct conversion of aldehydes to cyanamides was developed featuring a wide substrate scope and great functional group tolerability. This method allows for transformations of readily available,… read more here.
Keywords: mediated one; cascade process; cascade; so2f2 mediated ... See more keywords
Photoredox mediated one-step syntheses of aryl C-glycosides from unprotected glycosyl sulfinates.
Sign Up to like & getrecommendations! Published in 2025 at "Chemical communications"
DOI: 10.1039/d5cc03316k
Abstract: Unprotected glycosyl sulfinates undergo Ni-mediated cross coupling with a range of aryl iodides and bromides under photoredox conditions to yield aryl C-glycosides, predominantly as the β-anomers. Thioglycoside formation is occasionally observed as a competitive side… read more here.
Keywords: photoredox mediated; glycosyl sulfinates; aryl glycosides; mediated one ... See more keywords
Molybdenum-Mediated One-Pot Synthesis of Pyrazoles from Isoxazoles
Sign Up to like & getrecommendations! Published in 2019 at "Synthesis"
DOI: 10.1055/s-0039-1690615
Abstract: A one-pot approach for the direct synthesis of substituted pyrazoles from isoxazoles is reported. The process involves isoxazole N–O bond cleavage mediated by a molybdenum complex, in situ hydrolysis of the resulting β-amino enone to… read more here.
Keywords: molybdenum mediated; mediated one; one pot; pyrazoles isoxazoles ... See more keywords
Further Studies on Ni/Zr-mediated One-pot Ketone Synthesis: Use of a Mixture of NiI- and NiII-catalysts Greatly Improves the Molar Ratio of Coupling Partners
Sign Up to like & getrecommendations! Published in 2019 at "Chemistry Letters"
DOI: 10.1246/cl.190405
Abstract: A new Ni/Zr-mediated one-pot ketone synthesis is developed, with use of a mixture of (Me)3tpy·NiII- and py-(Me)imid·NiIICl2-catalysts. The NiI-catalyst selectively activates iodides, whereas the Ni... read more here.
Keywords: use mixture; mediated one; one pot; ketone synthesis ... See more keywords
Nitric oxide modulates folate-mediated one-carbon metabolism and mitochondrial energy levels of peaches during cold storage
Sign Up to like & getrecommendations! Published in 2023 at "Frontiers in Nutrition"
DOI: 10.3389/fnut.2023.1184736
Abstract: Folate-mediated one-carbon metabolism (FOCM) is closely associated with postharvest preservation. This study investigated the effects of exogenous nitric oxide (NO) on FOCM, storage quality, energy metabolism, and mitochondrial membrane integrity in cold-storage peach fruit. In… read more here.
Keywords: metabolism; energy; folate mediated; mediated one ... See more keywords