Pathway analysis of genetic variants in folate‐mediated one‐carbon metabolism‐related genes and survival in a prospectively followed cohort of colorectal cancer patients
Sign Up to like & getrecommendations! Published in 2018 at "Cancer Medicine"
DOI: 10.1002/cam4.1407
Abstract: Folate‐mediated one‐carbon metabolism (FOCM) is a key pathway essential for nucleotide synthesis, DNA methylation, and repair. This pathway is a critical target for 5‐fluorouracil (5‐FU), which is predominantly used for colorectal cancer (CRC) treatment. A… read more here.
Keywords: folate mediated; mediated one; metabolism; related genes ... See more keywords
Montmorillonite-KSF mediated one step synthesis of pyranochromene derivatives
Sign Up to like & getrecommendations! Published in 2018 at "Journal of Molecular Structure"
DOI: 10.1016/j.molstruc.2018.06.052
Abstract: Abstract One-pot three-component reaction of substituted aromatic aldehydes, 2-cyanoacetamide and 4-hydroxycoumarin in the presence of Montmorillonite-KSF (MKSF) in ethanol results in the formation of pyrano[3,2-c]chromene-3-carboxylates (5a-m) has been described. The reaction was tested in different… read more here.
Keywords: mediated one; ksf mediated; one step; reaction ... See more keywords
TPGS-mediated one-pot synthesis, XRD structural analysis, antimicrobial evaluation and molecular docking of novel heterocycles as potential inhibitors of p53-MDM2 protein
Sign Up to like & getrecommendations! Published in 2020 at "Journal of Molecular Structure"
DOI: 10.1016/j.molstruc.2019.127252
Abstract: Abstract Novel heterocyclic bioactive small molecules bearing thioether moiety, fluorine containing dihydro pyridine and dihydro pyran were synthesized and characterized using spectroscopic methods (FT-IR, 1H, 13C and 19F NMR), LC-MS and SC-XRD. The reaction conducted… read more here.
Keywords: tpgs mediated; mediated one; one pot; p53 mdm2 ... See more keywords
CRISPR-Cas9 mediated one-step disabling of pancreatogenesis in pigs
Sign Up to like & getrecommendations! Published in 2017 at "Scientific Reports"
DOI: 10.1038/s41598-017-08596-5
Abstract: Genome editing using programmable nucleases has revolutionized biomedical research. CRISPR-Cas9 mediated zygote genome editing enables high efficient production of knockout animals suitable for studying development and relevant human diseases. Here we report efficient disabling pancreatogenesis… read more here.
Keywords: mediated one; crispr cas9; disabling pancreatogenesis; cas9 mediated ... See more keywords
SO2F2-Mediated one-pot cascade process for transformation of aldehydes (RCHO) to cyanamides (RNHCN)
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DOI: 10.1039/d0ra02631j
Abstract: A simple, mild and practical cascade process for the direct conversion of aldehydes to cyanamides was developed featuring a wide substrate scope and great functional group tolerability. This method allows for transformations of readily available,… read more here.
Keywords: mediated one; cascade process; cascade; so2f2 mediated ... See more keywords
Molybdenum-Mediated One-Pot Synthesis of Pyrazoles from Isoxazoles
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DOI: 10.1055/s-0039-1690615
Abstract: A one-pot approach for the direct synthesis of substituted pyrazoles from isoxazoles is reported. The process involves isoxazole N–O bond cleavage mediated by a molybdenum complex, in situ hydrolysis of the resulting β-amino enone to… read more here.
Keywords: molybdenum mediated; mediated one; one pot; pyrazoles isoxazoles ... See more keywords
Further Studies on Ni/Zr-mediated One-pot Ketone Synthesis: Use of a Mixture of NiI- and NiII-catalysts Greatly Improves the Molar Ratio of Coupling Partners
Sign Up to like & getrecommendations! Published in 2019 at "Chemistry Letters"
DOI: 10.1246/cl.190405
Abstract: A new Ni/Zr-mediated one-pot ketone synthesis is developed, with use of a mixture of (Me)3tpy·NiII- and py-(Me)imid·NiIICl2-catalysts. The NiI-catalyst selectively activates iodides, whereas the Ni... read more here.
Keywords: use mixture; mediated one; one pot; ketone synthesis ... See more keywords
Nitric oxide modulates folate-mediated one-carbon metabolism and mitochondrial energy levels of peaches during cold storage
Sign Up to like & getrecommendations! Published in 2023 at "Frontiers in Nutrition"
DOI: 10.3389/fnut.2023.1184736
Abstract: Folate-mediated one-carbon metabolism (FOCM) is closely associated with postharvest preservation. This study investigated the effects of exogenous nitric oxide (NO) on FOCM, storage quality, energy metabolism, and mitochondrial membrane integrity in cold-storage peach fruit. In… read more here.
Keywords: metabolism; energy; folate mediated; mediated one ... See more keywords
Vitamin C Activates the Folate-Mediated One-Carbon Cycle in C2C12 Myoblasts
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DOI: 10.3390/antiox9030217
Abstract: Vitamin C (L-ascorbic acid, AA) is an essential cellular antioxidant and cofactor for several α-ketoglutarate-dependent dioxygenases. As an antioxidant, AA interacts with vitamin E to control oxidative stress. While several reports suggest an interaction of… read more here.
Keywords: folate mediated; mediated one; carbon cycle; c2c12 ... See more keywords