Low doses of niclosamide and quinacrine combination yields synergistic effect in melanoma via activating autophagy-mediated p53-dependent apoptosis.
Sign Up to like & getrecommendations! Published in 2022 at "Translational oncology"
DOI: 10.1016/j.tranon.2022.101425
Abstract: Malignant melanoma is a highly aggressive, malignant, and drug-resistant tumor. It lacks an efficient treatment approach. In this study, we developed a novel anti-melanoma strategy by using anti-tapeworm drug niclosamide and anti-malarial drug quinacrine, and… read more here.
Keywords: low doses; niclosamide quinacrine; melanoma; apoptosis ... See more keywords
Non-human primate papillomavirus E6-mediated p53 degradation reveals ancient evolutionary adaptation of carcinogenic phenotype to host niche
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DOI: 10.1371/journal.ppat.1010444
Abstract: Non-human primates (NHPs) are infected with papillomaviruses (PVs) closely related to their human counterparts, but there are few studies on the carcinogenicity of NHP-PVs. Using an in vitro cell co-transfection assay, we systematically screened the… read more here.
Keywords: p53 degradation; mediated p53; host; degradation ... See more keywords
Targeting IRES-Mediated p53 Synthesis for Cancer Diagnosis and Therapeutics
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DOI: 10.3390/ijms18010093
Abstract: While translational regulation of p53 by the internal ribosome entry site (IRES) at its 5′-untranslated region following DNA damage has been widely accepted, the detailed mechanism underlying the translational control of p53 by its IRES… read more here.
Keywords: ires mediated; mediated p53; diagnosis therapeutics; cancer diagnosis ... See more keywords