EBV infection in epithelial malignancies induces resistance to antitumor natural killer cells via F3-mediated platelet aggregation.
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DOI: 10.1158/0008-5472.can-21-2292
Abstract: Nasopharyngeal carcinoma (NPC) and Epstein-Barr virus (EBV)-associated gastric carcinoma (EBVaGC) are two major EBV-associated epithelial malignancies, both of which are characterized by the infiltration of a large number of lymphocytes, including natural killer (NK) cells.… read more here.
Keywords: epithelial malignancies; ebv associated; mediated platelet; platelet aggregation ... See more keywords
Differential integrin activity mediated by platelet collagen receptor engagement under flow conditions
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DOI: 10.1160/th16-12-0906
Abstract: Summary The platelet receptors glycoprotein (Gp)VI, integrin α 2 β 1 and GpIb/V/IX mediate platelet adhesion and activation during thrombogenesis. Increases of intracellular Ca 2+ ([Ca 2+ ] i ) are key signals during platelet… read more here.
Keywords: collagen; platelet adhesion; mediated platelet; flow conditions ... See more keywords
Selective Inhibition of PAR4 (Protease-Activated Receptor 4)-Mediated Platelet Activation by a Synthetic Nonanticoagulant Heparin Analog
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DOI: 10.1161/atvbaha.118.311758
Abstract: Objective— PAR4 (protease-activated receptor 4), one of the thrombin receptors in human platelets, has emerged as a promising target for the treatment of arterial thrombotic disease. Previous studies implied that thrombin exosite II, known as… read more here.
Keywords: thrombin; activation; par4; heparin ... See more keywords
Oligosaccharide Blocks PAR1 (Proteinase-Activated Receptor 1)-PAR4–Mediated Platelet Activation by Binding to Thrombin Exosite II and Impairs Thrombosis
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DOI: 10.1161/atvbaha.122.318085
Abstract: Background: Inappropriate activation and aggregation of platelets can lead to arterial thrombosis. Thrombin is the most potent platelet agonist that activates human platelets via two PARs (proteinase-activated receptors), PAR1 and PAR4. The aim is to… read more here.
Keywords: thrombin exosite; mediated platelet; platelet activation; binding thrombin ... See more keywords
Neutrophil Cathepsin G Enhances Thrombogenicity of Mildly Injured Arteries via ADP-Mediated Platelet Sensitization
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DOI: 10.3390/ijms23020744
Abstract: Inhalation of particulate matter in polluted air causes direct, size-restricted passage in the circulation and pronounced lung inflammation, provoking platelet activation and (non)-fatal cardiovascular complications. To determine potency and mechanism of platelet sensitization via neutrophil… read more here.
Keywords: cathepsin; mediated platelet; platelet sensitization; platelet ... See more keywords