Solution-mediated polymorphic transformation of CL-20: An approach to prepare purified form ε particles
Sign Up to like & getrecommendations! Published in 2018 at "Journal of Molecular Liquids"
DOI: 10.1016/j.molliq.2018.05.121
Abstract: Abstract The solution-mediated polymorphic transformation (SMPT) of 2,4,6,8,10,12-hexanitro-2,4,6,8,10,12-hexaazaisowurtzitane (CL-20) from form β to form e was investigated in ethyl acetate-chloroform mixed solvent. The transformation process was revealed by using on-line tools including attenuated total reflectance-Fourier… read more here.
Keywords: mediated polymorphic; form; transformation; process ... See more keywords
Solvent-Mediated Polymorphic Transformations in Molten Polymers: The Account of Acetaminophen.
Sign Up to like & getrecommendations! Published in 2022 at "Molecular pharmaceutics"
DOI: 10.1021/acs.molpharmaceut.2c00035
Abstract: Solvent-mediated polymorphic transformations (SMPTs) employing nonconventional solvents (polymer melts) is an underexplored research topic that limits the application of polymer-based formulation processes. Acetaminophen (ACM), a widely studied active pharmaceutical ingredient (API), is known to present… read more here.
Keywords: polymorphic transformations; time smpt; induction time; transformations molten ... See more keywords
Species Specificity and Selection of Models for Drug Oxidations Mediated by Polymorphic Human Enzymes
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DOI: 10.1124/dmd.121.000742
Abstract: Many drug oxygenations are mainly mediated by polymorphic cytochromes P450 (P450s) and also by flavin-containing monooxygenases (FMOs). More than 50 years of research on P450/FMO-mediated drug oxygenations have clarified their catalytic roles. The natural product… read more here.
Keywords: drug metabolism; p450; drug; mediated polymorphic ... See more keywords