The Natural Product Butylcycloheptyl Prodiginine Binds Pre-miR-21, Inhibits Dicer-Mediated Processing of Pre-miR-21, and Blocks Cellular Proliferation.
Sign Up to like & getrecommendations! Published in 2019 at "Cell chemical biology"
DOI: 10.1016/j.chembiol.2019.04.011
Abstract: Identification of RNA-interacting pharmacophores could provide chemical probes and, potentially, small molecules for RNA-based therapeutics. Using a high-throughput differential scanning fluorimetry assay, we identified small-molecule natural products with the capacity to bind the discrete stem-looped… read more here.
Keywords: butylcycloheptyl prodiginine; dicer mediated; pre mir; mir ... See more keywords
Spc1 regulates the signal peptidase-mediated processing of membrane proteins
Sign Up to like & getrecommendations! Published in 2021 at "Journal of Cell Science"
DOI: 10.1242/jcs.258936
Abstract: ABSTRACT Signal peptidase (SPase) cleaves the signal sequences (SSs) of secretory precursors. It contains an evolutionarily conserved membrane protein subunit, Spc1, that is dispensable for the catalytic activity of SPase and whose role remains unknown.… read more here.
Keywords: spase; membrane proteins; spc1; signal peptidase ... See more keywords
SPCS1-Dependent E2-p7 processing determines HCV Assembly efficiency
Sign Up to like & getrecommendations! Published in 2022 at "PLoS Pathogens"
DOI: 10.1371/journal.ppat.1010310
Abstract: Recent studies identified signal peptidase complex subunit 1 (SPCS1) as a proviral host factor for Flaviviridae viruses, including HCV. One of the SPCS1’s roles in flavivirus propagation was attributed to its regulation of signal peptidase… read more here.
Keywords: processing; spc mediated; spcs1; mediated processing ... See more keywords