E3 ubiquitin ligase TRIM24 deficiency promotes NLRP3/caspase‐1/IL‐1β‐mediated pyroptosis in endometriosis
Sign Up to like & getrecommendations! Published in 2021 at "Cell Biology International"
DOI: 10.1002/cbin.11592
Abstract: Endometriosis is an inflammation‐dependent disease that shares similarities with malignant tumors including attachment and infiltration. Tripartite motif‐containing 24 (TRIM24) has been illustrated in inflammatory responses and gynecological tumors, and Nod‐like receptor protein 3 (NLRP3) inflammasome… read more here.
Keywords: trim24; nlrp3 caspase; endometriosis; mediated pyroptosis ... See more keywords
Metformin ameliorates the NLPP3 inflammasome mediated pyroptosis by inhibiting the expression of NEK7 in diabetic periodontitis.
Sign Up to like & getrecommendations! Published in 2020 at "Archives of oral biology"
DOI: 10.1016/j.archoralbio.2020.104763
Abstract: OBJECTIVES To investigate the underlying mechanism between diabetic periodontitis and NLR family pyrin domain containing 3 (NLRP3) inflammasome associated pyroptosis. DESIGN Experimental models of diabetes-associated periodontitis were implemented in db/db mice. We detected NLRP3 inflammasome… read more here.
Keywords: inflammasome; mediated pyroptosis; expression; diabetic periodontitis ... See more keywords
"Chemical modulation of gasdermin-mediated pyroptosis and therapeutic potential".
Sign Up to like & getrecommendations! Published in 2021 at "Journal of molecular biology"
DOI: 10.1016/j.jmb.2021.167183
Abstract: Pyroptosis, a lytic form of programmed cell death, both stimulates effective immune responses and causes tissue damage. Gasdermin (GSDM) proteins are a family of pore-forming executors of pyroptosis. While the most-studied member, GSDMD, exerts critical… read more here.
Keywords: modulation gasdermin; biology; mediated pyroptosis; chemical modulation ... See more keywords
NLRP3 inflammasome-mediated pyroptosis contributes to the pathogenesis of non-ischemic dilated cardiomyopathy
Sign Up to like & getrecommendations! Published in 2020 at "Redox Biology"
DOI: 10.1016/j.redox.2020.101523
Abstract: Dilated cardiomyopathy (DCM) is one of the most common causes of heart failure, and the underlying mechanism remains largely elusive. Here we investigated whether NLRP3 inflammasome-mediated pyroptosis contributes to non-ischemic DCM and dissected the underlying… read more here.
Keywords: pyroptosis; mediated pyroptosis; activation; inflammasome mediated ... See more keywords
Crucial Function of Caveolin-1 in Deoxynivalenol-Induced Enterotoxicity by Activating ROS-Dependent NLRP3 Inflammasome-Mediated Pyroptosis.
Sign Up to like & getrecommendations! Published in 2022 at "Journal of agricultural and food chemistry"
DOI: 10.1021/acs.jafc.2c04854
Abstract: Deoxynivalenol (DON) is one of the most pervasive contaminating mycotoxins in grain, and exposure to DON is known to cause acute and chronic intestinal damage. As the gut is the most important target organ of… read more here.
Keywords: pyroptosis; oxidative stress; mediated pyroptosis; induced enterotoxicity ... See more keywords
Nobiletin triggers ROS-mediated pyroptosis through regulating autophagy in ovarian cancer cells.
Sign Up to like & getrecommendations! Published in 2020 at "Journal of agricultural and food chemistry"
DOI: 10.1021/acs.jafc.9b07908
Abstract: Ovarian cancer is one of the most serious female malignancies worldwide. Despite intensive effort has been made to overcome ovarian cancer, there still remain limited optional treatments for this disease. Nobiletin, a prospective Food-derived phytochemical,… read more here.
Keywords: ros mediated; mediated pyroptosis; ovarian cancer; cancer cells ... See more keywords
GSDME-mediated pyroptosis promotes inflammation and fibrosis in obstructive nephropathy.
Sign Up to like & getrecommendations! Published in 2021 at "Cell death and differentiation"
DOI: 10.1038/s41418-021-00755-6
Abstract: Renal tubular cell (RTC) death and inflammation contribute to the progression of obstructive nephropathy, but its underlying mechanisms have not been fully elucidated. Here, we showed that Gasdermin E (GSDME) expression level and GSDME-N domain… read more here.
Keywords: inflammation fibrosis; gsdme mediated; obstructive nephropathy; gsdme ... See more keywords
Coronaviruses Nsp5 Antagonizes Porcine Gasdermin D-Mediated Pyroptosis by Cleaving Pore-Forming p30 Fragment
Sign Up to like & getrecommendations! Published in 2022 at "mBio"
DOI: 10.1128/mbio.02739-21
Abstract: Recently, GSDMD has been reported as a key executioner for pyroptosis. This study first demonstrates the molecular mechanism of pGSDMD-mediated pyroptosis and that the pGSDMD-mediated pyroptosis protects host cells against PEDV infection. ABSTRACT Coronaviruses (CoVs)… read more here.
Keywords: pgsdmd mediated; porcine gasdermin; infection; pyroptosis ... See more keywords
PSMB5 Alleviates Ulcerative Colitis by Inhibiting ROS-Dependent NLRP3 Inflammasome-Mediated Pyroptosis
Sign Up to like & getrecommendations! Published in 2022 at "Disease Markers"
DOI: 10.1155/2022/2329904
Abstract: Ulcerative colitis (UC) is a chronic inflammatory disease. Intestinal mucosal injury is a significant factor in UC. Pyroptosis is a kind of programmed cell death induced by inflammatory caspases. Proteasome 20S subunit beta 5 (PSMB5)… read more here.
Keywords: mediated pyroptosis; pyroptosis; psmb5; ulcerative colitis ... See more keywords
Schisandrin A from Schisandra chinensis Attenuates Ferroptosis and NLRP3 Inflammasome-Mediated Pyroptosis in Diabetic Nephropathy through Mitochondrial Damage by AdipoR1 Ubiquitination
Sign Up to like & getrecommendations! Published in 2022 at "Oxidative Medicine and Cellular Longevity"
DOI: 10.1155/2022/5411462
Abstract: Schisandra chinensis, as a Chinese functional food, is rich in unsaturated fatty acids, minerals, vitamins, and proteins. Hence, this study was intended to elucidate the effects and biological mechanism of Schisandrin A from Schisandra chinensis… read more here.
Keywords: schisandra chinensis; schisandrin; mediated pyroptosis; mitochondrial damage ... See more keywords
NLRP3/caspase-1/GSDMD–mediated pyroptosis exerts a crucial role in astrocyte pathological injury in mouse model of depression
Sign Up to like & getrecommendations! Published in 2021 at "JCI Insight"
DOI: 10.1172/jci.insight.146852
Abstract: Emerging evidence suggests that astrocyte loss is one of the most important pathological features in the hippocampus of patients with major depressive disorder (MDD) and depressive mice. Pyroptosis is a recently discovered form of programmed… read more here.
Keywords: gsdmd mediated; gsdmd; pyroptosis; pathological injury ... See more keywords