Copper-Mediated Radiosynthesis of [18F]Rucaparib.
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DOI: 10.1021/acs.orglett.1c02770
Abstract: The poly(ADP-ribose) polymerase (PARP) inhibitor rucaparib is used in the clinic to treat BRCA-mutated cancers. Herein, we report two strategies to access the 18F-isotopologue of rucaparib by applying a copper-mediated nucleophilic 18F-fluorodeboronation. The most successful… read more here.
Keywords: copper mediated; mediated radiosynthesis; rucaparib; 18f rucaparib ... See more keywords