2-Substituted 3,7,8-trimethylnaphtho[1,2-b]furan-4,5-diones as specific L-shaped NQO1-mediated redox modulators for the treatment of non-small cell lung cancer.
Sign Up to like & getrecommendations! Published in 2017 at "European journal of medicinal chemistry"
DOI: 10.1016/j.ejmech.2017.06.028
Abstract: Based on the scaffold of 3,7,8-trimethylnaphtho[1,2-b]furan-4,5-dione, a series of L-shaped derivatives with substituted side chains at the position of C2 were designed by analyzing the binding mode with NQO1. The drug-like compound 6q (named as… read more here.
Keywords: redox modulators; cell; mediated redox; cancer ... See more keywords
Separation of Biological Events from the Photoanode: Toward the Ferricyanide-Mediated Redox Cyclic Photoelectrochemical System of an Integrated Photoanode and Photocathode.
Sign Up to like & getrecommendations! Published in 2020 at "ACS sensors"
DOI: 10.1021/acssensors.0c01695
Abstract: Photoanode sensing platforms with remarkable photoelectrochemical (PEC) response and satisfying visible-light absorption have become the most promising detection systems. Nevertheless, their inevitable electrophilic character limits their expansion in the bioassay because of reductive substances in… read more here.
Keywords: biological events; detection; system; separation biological ... See more keywords
Receptor-Mediated Redox Imbalance: An Emerging Clinical Avenue against Aggressive Cancers
Sign Up to like & getrecommendations! Published in 2022 at "Biomolecules"
DOI: 10.3390/biom12121880
Abstract: Cancer cells are more vulnerable to abnormal redox fluctuations due to their imbalanced antioxidant system, where cell surface receptors sense stress and trigger intracellular signal relay. As canonical targets of many targeted therapies, cell receptors… read more here.
Keywords: aggressive cancers; cell; receptor mediated; mediated redox ... See more keywords