Protein mediated regulation of the NHE1 isoform of the Na+/H+ exchanger in renal cells. A regulatory role of Hsp90 and AKT kinase.
Sign Up to like & getrecommendations! Published in 2017 at "Cellular signalling"
DOI: 10.1016/j.cellsig.2017.05.003
Abstract: Na+/H+ exchanger isoform one (NHE1) is a pH regulatory protein that is present in renal tissues and serves to remove protons from within cells and protect against intracellular acidification. NHE1 has a large 315 amino… read more here.
Keywords: protein; protein mediated; hsp90; mediated regulation ... See more keywords
Baicalin mediated regulation of key signaling pathways in cancer.
Sign Up to like & getrecommendations! Published in 2020 at "Pharmacological research"
DOI: 10.1016/j.phrs.2020.105387
Abstract: Baicalin has been widely investigated against different types of malignancies both at the cellular and molecular levels over the past few years. Due to its remarkable anti-proliferative potential in numerous cancer cell lines, it has… read more here.
Keywords: signaling pathways; baicalin; baicalin mediated; mediated regulation ... See more keywords
Molecular Mobility-Mediated Regulation of E-Cadherin Adhesion.
Sign Up to like & getrecommendations! Published in 2019 at "Trends in biochemical sciences"
DOI: 10.1016/j.tibs.2019.10.012
Abstract: Cells in epithelial tissues utilize homotypic E-cadherin interaction-mediated adhesions to both physically adhere to each other and sense the physical properties of their microenvironment, such as the presence of other cells in close vicinity or… read more here.
Keywords: mediated regulation; mobility mediated; molecular mobility; cadherin ... See more keywords
Cardiac mitochondrial dynamics: miR-mediated regulation during cardiac injury.
Sign Up to like & getrecommendations! Published in 2017 at "Journal of molecular and cellular cardiology"
DOI: 10.1016/j.yjmcc.2017.07.003
Abstract: Mitochondrial integrity is indispensable for cardiac health. With the advent of modern imaging technologies, mitochondrial motility and dynamics within the cell are extensively studied. Terminally differentiated and well-structured cardiomyocytes depict little mitochondrial division and fusion,… read more here.
Keywords: mediated regulation; dynamics mir; cardiac mitochondrial; mitochondrial dynamics ... See more keywords
Neuroprotective effect of canagliflozin against cisplatin-induced cerebral cortex injury is mediated by regulation of HO-1/PPAR-γ, SIRT1/FOXO-3, JNK/AP-1, TLR4/iNOS, and Ang II/Ang 1–7 signals
Sign Up to like & getrecommendations! Published in 2022 at "Immunopharmacology and Immunotoxicology"
DOI: 10.1080/08923973.2022.2143371
Abstract: Abstract Objectives Canagliflozin (CAN), a sodium-glucose co-transporter 2 inhibitor, is an anti-hyperglycemic drug that has been approved to treat diabetes. This study evaluated the beneficial effects of CAN on cerebral cortex intoxication induced by cisplatin… read more here.
Keywords: mediated regulation; cerebral cortex; cis; ang signals ... See more keywords
Investigating microRNA-mediated regulation of the nascent nuclear transcripts in plants: a bioinformatics workflow
Sign Up to like & getrecommendations! Published in 2018 at "Briefings in bioinformatics"
DOI: 10.1093/bib/bbx069
Abstract: Most of the microRNAs (miRNAs) play their regulatory roles through posttranscriptional target decay or translational inhibition. For both plants and animals, these regulatory events were previously considered to take place in cytoplasm, as mature miRNAs… read more here.
Keywords: mediated regulation; plant; nascent nuclear; regulation nascent ... See more keywords
Structural insights into RapZ-mediated regulation of bacterial amino-sugar metabolism
Sign Up to like & getrecommendations! Published in 2017 at "Nucleic Acids Research"
DOI: 10.1093/nar/gkx732
Abstract: Abstract In phylogenetically diverse bacteria, the conserved protein RapZ plays a central role in RNA-mediated regulation of amino-sugar metabolism. RapZ contributes to the control of glucosamine phosphate biogenesis by selectively presenting the regulatory small RNA… read more here.
Keywords: sugar metabolism; amino sugar; rapz; mediated regulation ... See more keywords
Sequence determinants of polyadenylation-mediated regulation.
Sign Up to like & getrecommendations! Published in 2019 at "Genome research"
DOI: 10.1101/gr.247312.118
Abstract: The cleavage and polyadenylation reaction is a crucial step in transcription termination and pre-mRNA maturation in human cells. Despite extensive research, the encoding of polyadenylation-mediated regulation of gene expression within the DNA sequence is not… read more here.
Keywords: polyadenylation mediated; sequence; mediated regulation; cleavage ... See more keywords
TOR‐mediated regulation of metabolism in aging
Sign Up to like & getrecommendations! Published in 2017 at "Aging Cell"
DOI: 10.1111/acel.12689
Abstract: Cellular metabolism is regulated by the mTOR kinase, a key component of the molecular nutrient sensor pathway that plays a central role in cellular survival and aging. The mTOR pathway promotes protein and lipid synthesis… read more here.
Keywords: regulation metabolism; mediated regulation; tor mediated; metabolism ... See more keywords
Suppression of carboxylesterases by imatinib mediated by the down‐regulation of pregnane X receptor
Sign Up to like & getrecommendations! Published in 2017 at "British Journal of Pharmacology"
DOI: 10.1111/bph.13731
Abstract: Imatinib mesylate (IM) is a first‐line treatment for chronic myeloid leukaemia (CML) as a specific inhibitor of BCR‐ABL tyrosine kinase. As IM is widely used in CML, in combination with other drugs, the effects of… read more here.
Keywords: regulation pregnane; mediated regulation; carboxylesterases imatinib; imatinib mediated ... See more keywords
MicroRNA‐mediated regulation of immune responses to intestinal helminth infections
Sign Up to like & getrecommendations! Published in 2017 at "Parasite Immunology"
DOI: 10.1111/pim.12406
Abstract: Intestinal helminth infections are highly prevalent in the developing world, often resulting in chronic infection and inflicting high host morbidity. With the emergence of drug‐resistant parasites, a limited number of chemotherapeutic drugs available and stalling… read more here.
Keywords: mediated regulation; immune responses; intestinal helminth; helminth infections ... See more keywords