Establishing a Multivariate Model for Predictable Antisense RNA-Mediated Repression.
Sign Up to like & getrecommendations! Published in 2019 at "ACS synthetic biology"
DOI: 10.1021/acssynbio.8b00227
Abstract: Recent advances in our understanding of RNA folding and functions have facilitated the use of regulatory RNAs such as synthetic antisense RNAs (asRNAs) to modulate gene expression. However, despite the simple and universal complementarity rule,… read more here.
Keywords: target; mediated repression; repression; model ... See more keywords
EZH2‐mediated repression of Dkk1 promotes hepatic stellate cell activation and hepatic fibrosis
Sign Up to like & getrecommendations! Published in 2017 at "Journal of Cellular and Molecular Medicine"
DOI: 10.1111/jcmm.13153
Abstract: EZH2, a histone H3 lysine‐27‐specific methyltransferase, is involved in diverse physiological and pathological processes including cell proliferation and differentiation. However, the role of EZH2 in liver fibrosis is largely unknown. In this study, it was… read more here.
Keywords: dkk1; ezh2; mediated repression; ezh2 mediated ... See more keywords
Spatial distribution of the full-length members of the Grg family during embryonic neurogenesis reveals a “Grg-mediated repression map” in the mouse telencephalon
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DOI: 10.1371/journal.pone.0209369
Abstract: The full-length members of the Groucho/Transducin-like Enhancer of split gene family, namely Grg1-4, encode nuclear corepressors that act either directly, via interaction with transcription factors, or indirectly by modifying histone acetylation or chromatin structure. In… read more here.
Keywords: length members; full length; family; mediated repression ... See more keywords
Carboxamide Derivatives Are Potential Therapeutic AHR Ligands for Restoring IL-4 Mediated Repression of Epidermal Differentiation Proteins
Sign Up to like & getrecommendations! Published in 2022 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms23031773
Abstract: Atopic dermatitis (AD) is a common T-helper 2 (Th2) lymphocyte-mediated chronic inflammatory skin disease characterized by disturbed epidermal differentiation (e.g., filaggrin (FLG) expression) and diminished skin barrier function. Therapeutics targeting the aryl hydrocarbon receptor (AHR),… read more here.
Keywords: epidermal differentiation; differentiation proteins; mediated repression; differentiation ... See more keywords