Gene therapy by lentivirus‐mediated RNA interference targeting extracellular‐regulated kinase alleviates neuropathic pain in vivo
Sign Up to like & getrecommendations! Published in 2018 at "Journal of Cellular Biochemistry"
DOI: 10.1002/jcb.28090
Abstract: Neuropathic pain is an abnormal pain, which is related to the activation of extracellular‐regulated kinase (ERK) signaling. This study was to investigate the effects of ERK knockdown via lentivirus‐mediated RNA interference on allodynia in rats… read more here.
Keywords: lentivirus mediated; extracellular regulated; mediated rna; regulated kinase ... See more keywords
Importin β1 mediates nuclear import of the factors associated with nonsense-mediated RNA decay.
Sign Up to like & getrecommendations! Published in 2021 at "Biochemical and biophysical research communications"
DOI: 10.1016/j.bbrc.2021.01.034
Abstract: In eukaryotic cells, nonsense-mediated RNA decay (NMD) is an essential physiological mechanism coupled to translation, regulating the stability of abnormal RNA containing premature termination codon (PTC) and a significant fraction of normal transcriptomes. So far,… read more here.
Keywords: smg5 magoh; rna decay; nonsense mediated; mediated rna ... See more keywords
Mechanisms and implications of ADAR-mediated RNA editing in cancer.
Sign Up to like & getrecommendations! Published in 2017 at "Cancer letters"
DOI: 10.1016/j.canlet.2017.09.036
Abstract: Adenosine deaminases acting on RNA (ADARs) are enzymes that catalyze the conversion of adenosine (A) to inosine (I) in double-stranded RNAs. Inosine exhibits similar properties as guanosine. As a result, A-to-I editing has a great… read more here.
Keywords: mechanisms implications; mediated rna; rna editing; adar mediated ... See more keywords
Assembly of Metabolons in Yeast Using Cas6-Mediated RNA Scaffolding.
Sign Up to like & getrecommendations! Published in 2023 at "ACS synthetic biology"
DOI: 10.1021/acssynbio.2c00650
Abstract: Cells often localize pathway enzymes in close proximity to reduce substrate loss via diffusion and to ensure that carbon flux is directed toward the desired product. To emulate this strategy for the biosynthesis of heterologous… read more here.
Keywords: rna; cas6; luminescence signal; mediated rna ... See more keywords
Nonsense-mediated RNA decay in the brain: emerging modulator of neural development and disease
Sign Up to like & getrecommendations! Published in 2018 at "Nature Reviews Neuroscience"
DOI: 10.1038/s41583-018-0079-z
Abstract: Steady-state RNA levels are controlled by the balance between RNA synthesis and RNA turnover. A selective RNA turnover mechanism that has received recent attention in neurons is nonsense-mediated RNA decay (NMD). NMD has been shown to… read more here.
Keywords: neural development; rna decay; nonsense mediated; mediated rna ... See more keywords
RNA cancer nanomedicine: nanotechnology-mediated RNA therapy.
Sign Up to like & getrecommendations! Published in 2022 at "Nanoscale"
DOI: 10.1039/d1nr06991h
Abstract: It has been demonstrated that RNA molecules-mRNA, siRNA, microRNA, and sgRNA-regulate cancer-specific genes, and therefore, RNA-based therapeutics can suppress tumor progression and metastasis by selectively upregulating and silencing these genes. However, the innate defense mechanisms… read more here.
Keywords: nanotechnology; rna therapy; nanotechnology mediated; mediated rna ... See more keywords
MP01-05 CIRCXPO1-MEDIATED RNA M6A MODIFICATION PROMOTES THE PROGRESSION OF BLADDER CANCER
Sign Up to like & getrecommendations! Published in 2020 at "Journal of Urology"
DOI: 10.1097/ju.0000000000000815.05
Abstract: INTRODUCTION AND OBJECTIVE:Circular RNAs (circRNAs) have been identified as a novel class of endogenous noncoding RNA and characterized by its closed circular structure. The roles of circRNAs as th... read more here.
Keywords: circxpo1 mediated; modification promotes; m6a modification; rna m6a ... See more keywords
Nonsense-Mediated RNA Decay Factor UPF1 Is Critical for Posttranscriptional and Translational Gene Regulation in Arabidopsis
Sign Up to like & getrecommendations! Published in 2020 at "Plant Cell"
DOI: 10.1105/tpc.20.00244
Abstract: The RNA helicase and ATPase UPF1 affects transcriptome homeostasis and gene expression through nonsense-mediated RNA decay, splicing, and translation in Arabidopsis. Nonsense-mediated RNA decay (NMD) is an RNA control mechanism that has also been implicated… read more here.
Keywords: mediated rna; rna decay; gene; arabidopsis ... See more keywords
Demonstration of protein cooperativity mediated by RNA structure using the human protein PUM2.
Sign Up to like & getrecommendations! Published in 2019 at "RNA"
DOI: 10.1261/rna.068585.118
Abstract: Posttranslational gene regulation requires a complex network of RNA-protein interactions. Cooperativity, which tunes response sensitivities, originates from protein-protein interactions in many systems. For RNA-binding proteins, cooperativity can also be mediated through RNA structure. RNA structural… read more here.
Keywords: protein; mediated rna; protein pum2; rna structure ... See more keywords
N6-methyladenosine promotes induction of ADAR1-mediated A-to-I RNA editing to suppress aberrant antiviral innate immune responses
Sign Up to like & getrecommendations! Published in 2021 at "PLoS Biology"
DOI: 10.1371/journal.pbio.3001292
Abstract: Among over 150 distinct RNA modifications, N6-methyladenosine (m6A) and adenosine-to-inosine (A-to-I) RNA editing represent 2 of the most studied modifications on mammalian mRNAs. Although both modifications occur on adenosine residues, knowledge on potential functional crosstalk… read more here.
Keywords: adar1 mediated; mediated rna; rna; immune responses ... See more keywords
Targeting nonsense-mediated RNA decay does not increase progranulin levels in the Grn R493X mouse model of frontotemporal dementia
Sign Up to like & getrecommendations! Published in 2023 at "PLOS ONE"
DOI: 10.1371/journal.pone.0282822
Abstract: A common cause of frontotemporal dementia (FTD) are nonsense mutations in the progranulin (GRN) gene. Because nonsense mutations activate the nonsense-mediated RNA decay (NMD) pathway, we sought to inhibit this RNA turnover pathway as a… read more here.
Keywords: nonsense mediated; mouse; progranulin levels; progranulin ... See more keywords